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Investigation of the properties of membrane proteins (MPs) is essential to the successful development of medicines and biotechnology. However, their study is often complicated by denaturation caused by the use of detergents during conventional extraction methods. Copolymers of styrene and maleic acid (SMA) have shown promise in extracting MPs directly from cells while reconstituting lipid memb

Globally, road traffic accidents (RTAs) remain a major cause of death, particularly among individuals aged 15–30 years. While Sweden has been at the forefront of traffic safety through the Vision Zero initiative, in-hospital management remains crucial in determining RTA outcomes. Drawing on North American evidence suggesting improved survival at trauma centres, the Swedish healthcare system has in

Supersolids formed from dipolar Bose Einstein condensates (BECs) exhibit spontaneous density modulation while maintaining global phase coherence. This state of matter supports gapped amplitude (Higgs) excitations featuring a quadratic dispersion relation. While Higgs modes are typically strongly damped due to coupling with other amplitude and phase modes, imposing an experimentally realistic toroi

Aims: The main aim of the present study was to identify factors influencing health-related quality of life (HRQoL), as measured by EQ-5D-5L, in individuals 1 year after the acute phase of COVID-19.Methods: This cross-sectional study included 75 participants (51% females), 1 year after confirmed SARS-CoV-2 infection (76% hospitalised). Associations between HRQoL, measured by patient-reported outcom

ISSUES: Although alcohol consumption is linked to atrial fibrillation (AF), the relationship across different intake levels and between sexes remains unclear. This study presents the first network meta-analysis of prospective cohort studies bringing greater precision to these associations.APPROACH: A systematic review identified five meta-analyses on alcohol and AF risk. From these, 13 cohort stud

Epilepsy is a prevalent neurological disorder characterized by spontaneous recurrent seizures (SRS). Epileptogenesis is a multifaceted pathophysiological process that transforms a normal brain into one prone to chronic seizures. Targeting epileptogenesis is a compelling line of epilepsy therapy. Thus, discovering new drugs that oppose, mitigate, or modify epileptogenesis is a significant challenge

Aims/hypothesis: The aim of this work was to investigate whether baseline uric acid (UA) is associated with future complications among young individuals with newly diagnosed type 1 diabetes. Methods: UA levels were analysed in individuals, aged 15–34 years with newly diagnosed type 1 diabetes, from the nationwide Diabetes Incidence Study in Sweden (DISS) cohort to assess the relationship with macr

The twin transition, which combines green and digital innovation in economic activities, is increasingly central to policy agendas and is also receiving growing attention in regional research. However, accurately mapping green, digital and twin (both green and digital) economic activities across regions remains challenging, particularly due to data constraints. In this study, we advance this resea

Stiffening of tissue is a hallmark of cancer progression, promoting invasive phenotypes through altered cell-extracellular matrix (ECM) interactions. However, how fully formed epithelial structures respond to mechanical cues within their native ECM environment remains poorly understood. Here, using a 3D in situ stiffening hydrogel system that enables modulation of stiffness around mature normal ma

Introduction: The rapid expansion of mobile phone access has enabled low-cost SMS interventions to support adherence to antiretroviral therapy (ART). Although text messaging improves adherence and retention in HIV care, its cost-effectiveness for enhancing quality of life remains uncertain, particularly among adolescents in resource-limited settings. This study evaluated whether SMS reminders impr

Background: Nocturnal gastro-oesophageal reflux (nGER) is common in people with respiratory diseases, but its association with pulmonary abnormalities is not known. Aim: Investigate the association between nGER and pulmonary abnormalities on chest CT in an adult general population. Methods: In total, 28 846 individuals from the general population aged 50-64 years completed questionnaires and under

A concept of germ graphs and the M-function formalism are employed to construct large families of isospectral and isoscattering graphs. This approach represents a complete departure from the original approach pioneered by Sunada, where isospectral graphs are obtained as quotients of a certain large symmetric graph. Using the M-function formalism and the symmetries of the graph itself we construct

Introduction Autistic persons experience problems with movements and body awareness in everyday functionality, expressed in affected movement quality. Yet, there is a knowledge gap about the effects of interventions targeting these aspects in autistic persons. Objective To evaluate effects of Basic Body Awareness Therapy (BBAT) and treatment-as-usual (TAU), compared to TAU alone on movement qualit

Polyunsaturated fatty acids (PUFA) have been shown to reduce liver fat compared to saturated fat, but effects of a novel “anti-lipogenic” diet replacing carbohydrates with PUFA (LCPUFA) or a low-fat healthy Nordic diet (HND) rich in whole-grains are unknown. The objective of this study was to investigate the effects of these diets, as compared with usual care (UC), on liver fat (primary outcome) a

A classical state-preparation device cannot generate states in relative superposition. We introduce classical models in which devices that are individually unable to generate states with relative superposition can be stochastically coordinated to simulate sets of quantum states. These models have natural operational interpretation in prepare-and-measure scenarios and they can account for many non-

Controlled and sequence-selective DNA cleavage plays a crucial role in biomolecular engineering and nucleic acid technologies. Here, we report the development of cerium-coordinated catalytic hydrogel nanoparticles (Ce-CHNP) that exhibit single-strand-selective nuclease activity. Ce-CHNP was synthesized via a one-step polymerization process in which Ce(IV) coordinated with N-hydroxymethyl acrylamid

Background: Wrist osteoarthritis can cause persistent pain, reduced joint mobility, and difficulty performing daily activities, negatively impacting quality of life. Although patient education and exercise therapy are recommended as first-line treatments for osteoarthritis in other joints, evidence supporting these strategies for wrist osteoarthritis remains limited. This randomized controlled tri

Ultracold quantum gases with long-range anisotropic interactions host novel exotic phases of matter, such as supersolids, exhibiting both rigid and superfluid characteristics. The impact of this interplay on the out-of-equilibrium dynamics of dipolar gases, and in particular its connection with universal turbulent behavior, remains highly unexplored. Here, upon considering a dipolar Bose-Einstein

The growing challenge of antibiotic resistance calls for alternative therapeutic strategies beyond conventional antibiotics. Antibacterial Photodynamic Therapy (aPDT), based on the light-induced generation of Reactive Oxygen Species (ROS), offers a non-specific approach that is detrimental to bacterial cells at multiple levels. Here, we explore the photocatalytic properties of nitrogen-doped titan