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Objective To evaluate any association of the presence and severity of nine major symptoms (pain, tiredness, drowsiness, nausea, appetite, breathlessness, depression, anxiety, and perceived well-being) with sleep quality and duration in elderly men.Design and setting Cross-sectional analysis within the population-based VAScular and Chronic Obstructive Lung disease study (VASCOL) conducted in southe

Halide perovskite solar cells (PSCs) have emerged as a transformative photovoltaic technology, achieving unprecedented power conversion efficiencies. However, the development of electron-transport materials (ETMs), particularly organic ETMs, has significantly trailed behind the rapid progress in hole-transport materials (HTMs). Among the organic ETMs, naphthalene diimide (NDI)-based systems stand

This study examines the relationship between income-related health inequality (IRHI) and macroeconomic conditions. We complement an income group-based analysis of the impact of macroeconomic conditions on mortality by incorporating an analysis of the concentration index as a comprehensive measure of overall IRHI. Using a recentered influence function regression approach, we estimate the impact of

Stage- and lineage-specific gene expression patterns are controlled by a complex interplay between transcription factors, the epigenetic landscape, and the three-dimensional (3D) structure of the DNA. The 3D structure allows for the formation of DNA loops that juxtaposition distal regulatory elements to the promoters, allowing for tight control of gene expression. Developing a tool to facilitate t

Acoustofluidic particle manipulation has attracted considerable interest in biomedical applications due to its non-contact and label-free characteristics. However, existing computational models for predicting particle motion in acoustofluidic systems mainly focus on single-particle behavior, often neglecting particle–particle interactions and the impact of particle distribution on the acoustic and

Heart and lung transplantation remain the primary treatments for end-stage organ failure; yet organ shortages and ischemia-reperfusion injury (IRI) limit their success. Extended criteria donors (ECDs) have expanded the donor pool; however, prolonged cold ischemia times increase the risk of primary graft dysfunction (PGD). Static cold storage (SCS), the standard organ preservation method, is subopt

Background: Obstetrical anal sphincter injuries are complications of vaginal birth that have the potential to cause substantial maternal morbidity. Predicting these injuries might help to improve maternal care as well as antenatal counseling and patient education. Previous attempts to create prediction models have in many cases involved variables only known postpartum, which limits their use in an

Antibiotic persistence arises when a subset of cells in an otherwise susceptible bacterial population temporarily exhibits elevated tolerance to bactericidal antibiotics. While significant progress has been made in elucidating persister mechanisms, much of this research has focused on Gram-negative bacteria, and these findings are not always applicable to Gram-positive species. This study explores

Introduction: Extrauterine pregnancy (EP), represents a significant challenge in reproductive medicine, manifesting in approximately 2% of all pregnancies, primarily implanting within the fallopian tubes (95%). Surgery remains a cornerstone in the therapeutic options for ectopic pregnancies. The most common surgical approach at the moment is laparoscopy. However a relatively new surgical technique

Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are recognized as severe diseases of the lungs and are closely linked to cigarette smoking and environmental pollution and share common mechanisms such as oxidative stress, inflammation, matrix degradation, and airway remodeling. Epidermal growth factor receptor (EGFR), a transmembrane receptor featuring an extracellular ligand bind

Micro-LEDs have emerged as a hot research topic due to their potential for next-generation display and lighting applications, necessitating advanced characterization techniques to optimize their performance. This study demonstrates the advantage of cathodoluminescence in the scanning electron microscope to be a critical tool for the optical characterization of InGaN platelets with red quantum well

Introduction: Mycobacteria have a unique hydrophobic membrane with several lipid-enriched layers that are low in permeability, setting them apart from other bacteria. This complex structure, consisting of three distinct layers is crucial for cell growth, virulence, and providing a barrier to antibiotics. Previously, we identified a plectasin variant, NZX, which showed activity against Mycobacteriu

This study introduces a novel approach for synthesising a surface-imprinted polymer-ordered mesoporous silica adsorbent, known as SiO2@MIPs-CAPcr, with high selectivity for chloramphenicol (CAP) adsorption by employing an activator that was regenerated by electron atom transfer radical polymerisation (ARGET ATRP). Optimal synthesising conditions for SiO2@MIPs-CAPcr have been determined, including

Minimal Kitaev chains, composed of two quantum dots connected via a superconductor, have emerged as an attractive platform to realize Majorana bound states (MBSs). These excitations exist when the ground state is degenerate. The additional requirement of isolating the MBS wave functions further restricts the parameter space to discrete sweet spots. While scaling up to Kitaev chains with more than

The coherence factors of quasiparticles in a superconductor determine their properties, including transport as well as their susceptibility to electric fields. In this work, we propose a way to infer the local coherence factors using local transport to normal leads. Our method is based on measuring the local current through a lead as the coupling to a second one is varied; the shape of the current

Catalytic activity is improved by reducing particle size, followed by atomic scale structural and chemical design, allowing physical and electronic confinement of chemical conversion centers. These concepts culminate in single-atom catalysts (SACs) where active precious metal atoms are isolated and anchored on the surface of supports and thus fully utilized for chemical conversion. In contrast, me

BACKGROUND: Chronic obstructive pulmonary disease (COPD) has many known dysregulated inflammatory proteins. A disintegrin and metalloproteinase 17 (ADAM17) is a protease that sheds several proteins involved in COPD pathogenesis. The aim was to investigate ADAM17, its phosphorylated form (pADAM17) and its substrates in bronchoalveolar lavage (BAL) and blood from COPD and control subjects. METHODS:

Lignin, a structurally intricate and heterogeneous phenolic biopolymer, holds considerable promise as a sustainable alternative to petrochemical-derived materials across diverse applications in the energy and materials sectors. However, precise lignin molecular weight and structure determination remains challenging due to its intrinsic tendency to aggregate in solution and the absence of chem

Investigation of the properties of membrane proteins (MPs) is essential to the successful development of medicines and biotechnology. However, their study is often complicated by denaturation caused by the use of detergents during conventional extraction methods. Copolymers of styrene and maleic acid (SMA) have shown promise in extracting MPs directly from cells while reconstituting lipid memb