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Inflammation and autoimmunity are known as central processes in many skin diseases, including psoriasis. It is therefore important to develop pre-clinical models that describe disease-related aspects to enable testing of pharmaceutical drug candidates and formulations. A widely accepted pre-clinical model of psoriasis is the imiquimod (IMQ)-induced skin inflammation mouse model, where topically ap
PDE5 inhibitors was reported to play a protective role in both regulating lipid metabolism and reducing heart failure (HF). This study aimed to clarify the effectiveness of PDE5 inhibitors against hyperlipidemia-related HF by combining evidence from population-based study and animal models. The nationwide cohort study found that post-diagnostic use of PDE5 inhibitors was associated with a signific
Background and objective: We investigated whether adding 4Kscore as a reflex test to prostate-specific antigen (PSA) could improve the screening algorithm for prostate cancer (PC). Methods: In the GÖTEBORG-2 PC screening trial, 38 000men (50–60 yr) were invited to PSA testing and, if elevated, followed by magnetic resonance imaging (MRI). For 571 men with PSA ≥3.0 ng/ml and evaluable outcomes, 4Ks
Nano-scale chemical inhomogeneity in surface oxide films formed on a V- and N-containing martensite stainless steel and tempering heating induced changes are investigated by a combination of synchrotron- based hard X-ray Photoelectron emission spectroscopy (HAXPES) and microscopy (HAXPEEM) as well as microscopic X-ray absorption spectroscopy (μ-XAS) techniques. The results reveal the inhomogeneity
The effects of defects in In0.47Ga0.53As/Al2O3/Ni metal-oxide-semiconductor (MOS) stacks at cryogenic temperatures are investigated. The MOS stacks exhibit a hysteresis in the capacitance-voltage (CV) curve, both at room temperature and at 100K, indicating the presence of effective charge capture/emission dynamics in the oxide even at cryogenic temperatures. Border traps (BTs) in the Al2O3 close t
Solid-liquid interfaces are at the heart of a wide variety of phenomena. Their investigation requires experimental techniques with surface sensitivity such scanning probe microscopy and nonlinear optical techniques. In recent years, solid-liquid interfaces have been investigated with a novel approach based on the generation of high frequency acoustic and optical phonons. Due to the sensitivity of
Background and objective: The treatment landscape of metastatic prostate cancer (mPCa) has evolved significantly over the past two decades. Despite this, the optimal therapy for patients with mPCa has not been determined. This systematic review identifies available predictive models that assess mPCa patients’ response to treatment. Methods: We critically reviewed MEDLINE and CENTRAL in December 20
Fluorescent probes have become promising tools for monitoring the concentration of peroxynitrite, which is linked to many diseases. However, despite focusing on developing numerous peroxynitrite based fluorescent probes, limited emphasis is placed on their sensing mechanism. Here, we investigated the sensing mechanism of a peroxynitrite fluorescent probe, named BHID-Bpin, with a focus on the relev
Metal cutting is physically defined by a tool separating a chip by developing a stagnation point after the work material has passed a shear plane. This distinguishes the method group metal cutting or machining from shearing and wedging processes. The development of the stagnation point is central to the functioning of a metal cutting process. The stagnation point and its behavior has a great influ
Harnessing the advantages of shared entanglement for sending quantum messages often requires the implementation of complex two-particle entangled measurements. We investigate entanglement advantages in protocols that use only the simplest two-particle measurements, namely, product measurements. For experiments in which only the dimension of the message is known, we show that robust entanglement ad
Current syntheses of CsPbBr3 halide perovskite nanocrystals (NCs) rely on overstoichiometric amounts of Pb2+ precursors, resulting in unreacted lead ions at the end of the process. In our synthesis scheme of CsPbBr3 NCs, we replaced excess Pb2+ with different exogenous metal cations (M) and investigated their effect on the synthesis products. These cations can be divided into two groups: group 1 d
Heterotopic ossification (HO) in tendons can lead to increased pain and poor tendon function. Although it is believed to share some characteristics with bone, the structural and elemental compositions of HO deposits have not been fully elucidated. This study utilizes a multimodal and multiscale approach for structural and elemental characterization of HO deposits in healing rat Achilles tendons at
Obesity is a complex and chronic disease affecting hundreds of millions of people worldwide and has reached epidemic proportions. It is important to understand the underlying mechanisms to tackle this devastating disease, thus preventing its comorbidities. The epigenome, including DNA methylation and histone modifications, appears to be the link between genetics and nongenetic factors, modulating
Background: In prostate cancer (PCa), questions remain on indications for prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging and PSMA radioligand therapy, integration of advanced imaging in nomogram-based decision-making, dosimetry, and development of new theranostic applications. Objective: We aimed to critically review developments in molecular hybrid imaging an
Objectives Construction workers are exposed to respirable dust, including respirable crystalline silica (RCS), which is a potential risk factor for cardiovascular disease (CVD). The aim of this study was to evaluate whether exposure to particles among construction workers is associated with short-and long-term alterations in CVD-related serum proteins. Methods Using proximity extension assay, we m
The cooperative emission of interacting nanocrystals is an exciting topic fueled by recent reports of superfluorescence and superradiance in assemblies of perovskite nanocubes. Several studies estimated that coherent coupling is localized to a small fraction of nanocrystals (10−7-10−3) within the assembly, raising questions about the origins of localization and ways to overcome it. In this work, w
In nanoscale systems coupled to finite-size reservoirs, the reservoir temperature may fluctuate due to heat exchange between the system and the reservoirs. To date, a stochastic thermodynamic analysis of heat, work, and entropy production in such systems is, however, missing. Here we fill this gap by analyzing a single-level quantum dot tunnel coupled to a finite-size electronic reservoir. The sys
In this mini-review, we briefly summarize some of the main concepts and ideas behind highly dilute self-bound quantum droplets of both binary and dipolar character. The latter type of systems has more recently led to the experimental discovery of a dipolar supersolid state that allows entirely new insights on this long-sought purely quantum state of matter, with exciting prospects for fundamental
We study quantum steering experiments without assuming that the trusted party can perfectly control their measurement device. Instead, we introduce a scenario in which these measurements are subject to small imprecision. We show that small measurement imprecision can have a large detrimental influence in terms of false positives for steering inequalities, and that this effect can become even more
