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Human Brain Cell-Type-Specific Aging Clocks Based on Single-Nuclei Transcriptomics

Aging is the primary risk factor for most neurodegenerative diseases, yet the cell-type-specific progression of brain aging remains poorly understood. Here, human cell-type-specific transcriptomic aging clocks are developed using high-quality single-nucleus RNA sequencing data from post mortem human prefrontal cortex tissue of 31 donors aged 18–94 years, encompassing 73,941 high-quality nuclei. Di

Captivating bimolecular photoredox dynamics of a ligand-to-metal charge transfer complex

Transition metal complexes featuring ligand-to-metal charge transfer (LMCT) excited states have been identified as promising candidates for driving electron transfer processes. To obtain an efficient system based on photo-induced bimolecular electron transfer, it is required that (1) photo-induced charge separation (CS) is faster than charge recombination (CR) of the separated charges, and (2) CR

Hypothermia after Cardiac Arrest in Large Animals (HACA-LA) : a randomized controlled experimental study

Background: Induced hypothermia after cardiac arrest is neuroprotective in several animal models of cardiac arrest, but few high-quality studies have been conducted in larger animals. Recent clinical trials have questioned the beneficial effects of post-ischemic hypothermia. This study investigated whether immediate cooling or a 2-h delay in cooling to 33 °C after cardiac arrest was neuroprotectiv

High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia : Evidence From a 25-Year Prospective Cohort Study

BACKGROUND AND OBJECTIVES: The association between dairy intake and dementia risk remains uncertain, especially for dairy products with varying fat contents. The aim of this study was to investigate the association between high-fat and low-fat dairy intake and dementia risk.METHODS: This study used data from a prospective cohort in Sweden, the Malmö Diet and Cancer cohort, which consisted of commu

Trapping, coalescence, and splitting of drops in an ultrasound-actuated microcavity

Droplets are sophisticated micro-compartments crucial for lab-on-a-chip and bio-medical applications. There have been significant efforts towards generating monodisperse droplets as the uniformity of droplets affects performance. Recently, we introduced a new method to continuously reform existing emulsions improving monodispersity in an ultrasound-actuated microcavity via a trap-coalesce-split me

Human bone marrow organoids : emerging progress but persisting challenges

Organoid systems hold promise as miniaturized in vitro platforms that model developmental and pathological processes. However, the engineering of human bone marrow organoids (BMOs) has been a long-standing challenge. Recently, the field has witnessed the emergence of BMO-like systems, a potential paradigm shift for the study of human hematopoiesis and associated niche elements. Published protocols

Cardiovascular Morbidity in Patients Undergoing Successful Surgery for Primary Hyperparathyroidism

Objective: Although previous studies have shown reduced cardiovascular events following parathyroidectomy (PTX), it is unclear whether this extends to contemporary patients diagnosed and treated with milder disease than previously. The aim of this nation-wide study was to determine the effect on cardiovascular events after PTX, and to comprehensively evaluate cardiovascular disease manifestations

Oligomers mediate the spatial transmission of Aβ peptide aggregation

Alzheimer’s disease (AD) is marked by the abnormal aggregation of amyloid-beta peptides within the central nervous system. The formation of amyloid fibrils from amyloid-beta peptides is a hallmark of AD Here, we demonstrate that the aggregation of amyloid-beta 42 spreads both spatially and temporally. By measuring the spatial propagation of amyloid-beta in macroscopic capillaries and performing Mo

Impact of AlN buffer thickness on electrical and thermal characteristics of AlGaN/GaN/AlN HEMTs

We investigate the influence of AlN buffer thickness on the structural, electrical, and thermal properties of AlGaN/GaN high-electron mobility transistors (HEMTs) grown on semi-insulating SiC substrates by metal-organic chemical vapor deposition. X-ray diffraction and atomic force microscopy reveal that while thin AlN layers (120 nm) exhibit compressive strain and smooth step-flow surfaces, thicke

Advancing 90-day mortality and anastomotic leakage predictions after oesophagectomy for cancer using Explainable Artificial Intelligence

Introduction: Oesophageal resection carries significant morbidity and mortality. Artificial intelligence (AI) advances in medical research enable enhanced predictions, flexibility, and interpretability, especially for complex interactions and nonlinear relationships. Material and methods: We used a register-based case-control design nested within prospectively collected data from the Swedish Natio

Buried Interface evolution of 2D/3D heterojunction inverted perovskites solar cells

The instability of perovskite interfaces caused by interfacial defects and heterojunction evolution hinders the realization of long-term stable inverse perovskite solar cells (IPSCs). This work reports a strategy for the study of heterojunction evolution, the effects of buried interface and carrier dynamics on the stability of perovskite films and devices in 2D/3D heterojunctions. The emphasis is

Growth, structure, and morphology of ultra-thin tin oxide phases forming on Pt3Sn(111) single crystals upon exposure to oxygen

Here we report an investigation of ultrathin tin oxide films on Pt3Sn(111) using low-energy electron microscopy (LEEM), microspot low-energy electron diffraction (μ-LEED), scanning tunneling microscopy (STM), surface X-ray diffraction (SXRD), and high-resolution X-ray photoelectron spectroscopy (XPS). Oxidation at ∼390–410 °C produces triangular, two-dimensional oxide islands that nucleate rapidly

The Meaning of Surveillance in Women With a Hereditary Risk of Breast Cancer: A Hermeneutic Phenomenological Study

AimTo explore the meaning of lived experiences of women with a hereditary risk of breast cancer who participate in surveillance of their breasts with magnetic resonance imaging.DesignHermeneutic phenomenology.MethodsInterviews on two occasions were made with 14 women in the surveillance programme. The verbatim transcripts were analysed according to van Manen. The analysis was an insightful iterati

Raman spectroscopy in microfluidic chips reveals hyphal scale stress-associated metabolic responses in filamentous soil fungi

Understanding metabolic processes of soil fungi is essential for elucidating their ecological roles in biogeochemical cycles and responses to emergent environmental stressors. Here, we demonstrate the potential of using stable isotope probing Raman (SIP-Raman) microspectroscopy in microfluidics technology-based soil chips to trace glucose metabolism rates and stress responses in laboratory grown f

Experimental benchmarking of dielectric models for simulating the localized surface plasmon resonance in Au-Ag alloy nanospheres

The optical response of gold-silver (Au-Ag) alloy nanoparticles is strongly influenced by their localized surface plasmon resonance (LSPR), which can be tuned by varying the particle composition. Accurate simulation of LSPR, often performed using Mie theory, critically depends on the choice of dielectric function, yet available datasets for gold, silver, and their alloys vary widely. In this work,

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M 7768:1‐11  Landskap:  Småland    Upptecknat av:  Blenda Andersson  Härad:  Allbo    Adress:    Skörda, Vislanda sn  Socken:  Vislanda    Berättat av:    ‐‐‐‐  Uppteckningsår:   1941    Född år 1880 i Vislanda    Slåtter och skörd  (Självbiografi)  Då jag var 12‐13 år ansågs jag som en stor flicka, och fick från morgon till kväll hjälpa till vid slåttern  och skörden. Då far började med slåttern,

https://www.folklivsarkivet.lu.se/fileadmin/user_upload/folklivsarkivet/upload/levnadsminne/Blenda_A/M_7768_s_1-11.pdf - 2026-04-30

Arbetsordning Lunds Universitet

Beslut. Revidering av Arbetsordningen Sida 1 av 33 Universitetsstyrelsen BESLUT Diarienummer STYR 2018/1859 STYR 2019/907 STYR 2019/1903 STYR 2020/2283 STYR 2021/2702 STYR 2022/1481 2022-10-28 Arbetsordning för Lunds universitet Fastställd av universitetsstyrelsen 2018-12-14, § 12. Reviderad av universitetsstyrelsen 2022-10-28 § 11. Med stöd av 2 kap. 2 § första stycket 8 p högskoleförordningen (1

https://www.intramed.lu.se/sites/intramed.lu.se/files/2023-05/Arbetsordning%20Lunds%20universitet.pdf - 2026-05-01