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Magnesium and potassium concentrations were determined in plasma, erythrocytes and urine collected during 24 h, and in percutaneous muscle biopsies obtained in 30 healthy subjects. Magnesium was also analyzed in mononuclear cells. Men, compared to women, showed a higher urinary excretion of magnesium (p less than 0.05). The magnesium contents in mononuclear cells correlated significantly with the Magnesium and potassium concentrations were determined in plasma, erythrocytes and urine collected during 24 h, and in percutaneous muscle biopsies obtained in 30 healthy subjects. Magnesium was also analyzed in mononuclear cells. Men, compared to women, showed a higher urinary excretion of magnesium (p less than 0.05). The magnesium contents in mononuclear cells correlated significantly with the

In the foreword to the Mercure de France edition of Réflexions sur le procès de la reine, (1996 [1820, 1793]), Chantal Thomas, French historian and writer, writes that this apology in favour of Marie-Antoinette did not help the queen nor the author herself; on the contrary it only made the latter more unpopular. So why did Germaine de Staël write it? Mme de Staël and Marie-Antoinette did not shareIn the foreword to the Mercure de France edition of de Staël. (1996 [1793]. Réflexions sur le procès de la reine. Paris: Mercure de France), Chantal Thomas, French historian and writer, writes that this apology in favor of Marie-Antoinette did not help the queen nor the author herself; on the contrary it only made the latter more unpopular. So why did Germaine de Staël write it? Mme de Staël and M

Engaging with scholarship on hegemony, park history, and in particular with Sevilla-Buitrago’s analysis of Central Park as a pedagogical space, this article traces the establishment of two parks in the Swedish textile industry centre of Norrköping. These parks, bearing very similar names – Folkparken and Folkets Park – were established just six years apart. But though both parks linked “park” and

Aims: Transforming growth factor-beta (TGF-β) exists in three isoforms TGF-β1, -β2, and -β3. TGF-β1 has been suggested to be important for maintaining plaque stability, yet the role of TGF-β2 and -β3 in atherosclerosis remains to be investigated. This study explores the association of the three isoforms of TGF-β with plaque stability in the human atherosclerotic disease. Methods and results: TGF-β

Tomographic X-ray imaging techniques offer novel opportunities for studying membranes and membrane processes in 3D on a spatial resolution not seen before. Traditional 2D imaging techniques used to characterise membranes have limitations that can be overcome by tomographic X-ray imaging. Tomographic X-ray imaging can provide information in 2D/3D or 4D (3D plus time) on membranes, membrane modules,

Permafrost warming has the potential to amplify global climate change, because when frozen sediments thaw it unlocks soil organic carbon. Yet to date, no globally consistent assessment of permafrost temperature change has been compiled. Here we use a global data set of permafrost temperature time series from the Global Terrestrial Network for Permafrost to evaluate temperature change across permaf

Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL) rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact remains unclear. Using a retroviral acute myeloid mouse leukemia model, we demonstrate that FLT3 ITD, FLT3 N676K, and NRAS G12D accelerate KMT2A-MLLT3 leukemia onset. Further, also subclonal FLT3 N676K mutations accelerate

The depletion of disruptive variation caused by purifying natural selection (constraint) has been widely used to investigate protein-coding genes underlying human disorders 1–4, but attempts to assess constraint for non-protein-coding regions have proved more difficult. Here we aggregate, process and release a dataset of 76,156 human genomes from the Genome Aggregation Database (gnomAD)—the larges

Plasma metabolomics holds potential for precision medicine, but limited information is available to compare the performance of such methods across multiple cohorts. We compared plasma metabolite profiles after an overnight fast in 11,309 participants of five population-based Swedish cohorts (50–80 years, 52% women). Metabolite profiles were uniformly generated at a core laboratory (Metabolon Inc.)

The aim was to evaluate an early prototype of a personalised home lighting system comprising body-worn loggers, a mobile phone, and LED-based lighting with variable intensity and colour temperature. A convenience sample (N = 28, 50% female) wore the devices for 24 hours in the field and were given a demonstration of the lighting system components in a full-scale model of a studio apartment. Partic

We investigated multivoxel proton magnetic resonance spectroscopy (1H-MRS) biometrics for preoperative differentiation and prognosis of patients with brain metastases (MET), low-grade glioma (LGG) and high-grade glioma (HGG). In total, 33 patients (HGG, 14; LGG, 9; and 10 MET) were included. 1H-MRS imaging (MRSI) data were assessed and neurochemical profiles for metabolites N-acetyl aspartate (NAA

Lunds historia innehåller många medicinhistoriska händelser. Medicinhistoria som akademisk disciplin är dock inte endast deskriptiv utan även analyserande. Flera institutioner vid Lunds universitet bedriver medicinhistorisk forskning från olika utgångspunkter. Medicinhistoria är ett viktigt ämne för förståelsen av dagens medicin och denna översikt vill visa varför och hur ämnet behandlas vid Lunds

While organisms have evolved to cope with predictable changes in the environment, the rapid rate of current global change presents numerous novel and unpredictable stressors to which organisms have had less time to adapt. To persist in the urban environment, organisms must modify their physiology, morphology and behaviour accordingly. Metabolomics offers great potential for characterising organism

Oral assessment is an important method to evaluate the learning outcomes of scientific courses. However,there are certain limitations when oral assessment is applied.One of these limitations, which is not apparent in anonymous written exams, is the existence of biases which could lead to unfair (positive or negative) outcomes of the assessment. This could lead to decreased motivation and sense of

Recent studies of selective auditory attention have demonstrated that neural responses recorded with electroencephalogram (EEG) can be decoded to classify the attended talker in everyday multitalker cocktail-party environments. This is generally referred to as the auditory attention decoding (AAD) and could lead to a breakthrough for the next-generation of hearing aids (HAs) to have the ability to

Type 2 diabetes and dementia are associated, but it is unclear whether the two diseases have common genetic risk markers that could partly explain their association. It is also unclear whether the association between the two diseases is of a causal nature. Furthermore, few studies on diabetes and dementia have validated dementia end-points with high diagnostic precision. We tested associations bet

Immunotherapy is revolutionizing cancer treatment, but success is limited to a fraction of patients. Tumor immunosurveillance and immunotherapy relies on presentation of tumor-associated antigens by conventional dendritic cells type 1 (cDC1). However, tumors develop mechanisms to avoid immune recognition such as downregulation of antigen presentation and exclusion of cDC1. We have previously demon