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Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease with no known single predisposing genetic factor shown in all cases. Recently, a single nucleotide polymorphism (SNP) T393C in the GNAS1 gene has been reported to have a clinical impact on CLL progression and overall survival. In order to further investigate the T393C SNP in CLL, we have genotyped 279 CLL cases and correlated

Laser-induced fluorescence is a technique for optical tissue characterisation. It has a real-time capability and as the excitation light and the fluorescence emission are transmitted through optical fibres the technique is compatible to various kinds of endoscopes for hollow organ investigation. The tissue fluorescence itself with the emission from the endogenous chromophores or enhanced with exog

A selective and sensitive method is presented for biogenic amines (BA) determination. The novelty consists in coupling a highly selective electrochemical biosensor to a weak acid cation-exchange column for online detection of amines. A bienzyme design, based on a recently isolated amine oxidase from grass pea and commercial horseradish peroxidase, was used for the biosensor construction. The enzym

A common industrial process for separating particles from a liquid is continuous sedimentation, which is used in the chemical, mining, pulp-and-paper and food industries. It can also be found in most wastewater treatment plants, where it is a crucial subprocess of a complex biological system. The process has provided, and will continue to provide, scientific problems that lead to fundamental resea

The new challenge of the Gas Turbine industry is to develop new technologies for meeting electricity demand growth and reducing harmful emissions. Thus, a better understanding of the combustion phenomenon and an improvement in simulation capabilities are needed. In this paper, we present a new technique that is computationally efficient, for capturing the thermo-acoustic waves in low Mach number c

A number of researchers have attempted to define and encapsulate the essence of ‘critical research’. It has been suggested to encompass interpretation of social phenomena, and seeks for understandings that could support efforts to bring about beneficial change. It has been further suggested that such work is characterised by: concern with substantive social issues (e.g. power, values); foundation

Beskrivning ges av analysteknik (protoninducerad röntgenstrålning), provtagningsteknik (kaskadimpaktor av Battelle-typ) och provberedningsteknik. Utfört arbete i form av provbehandlingsförbättringar, konstruktion och förbättring av provtagare, bestämning av lämpliga analysparametrar samt uppbyggnad av ett dataprogramsystem presenteras. Sammanställning av resultat i form av beräknade medelvärden i

The main concern of this paper is the joint utilization of new methods of research and analysis in the study of value. 40 persons, varying from age 20 to 70 and from different professional domains were studies by the use of a three-images technique inspired by Murray´s TAT. The aim was to unveil the implicit dimensions of work related values. Three analytical methods (content analysis, lexical ana

Projektet har haft sitt största fokus vid att göra en djuplodande rättsutredning för att därmed kunna ange konkreta förslag på praktiskt användbara rättsliga lösningar för tillgängliggörande av öppna datakällor. Två tydliga förslag förs fram: 1. Riktlinjer för vidareutnyttjande av handlingar som finns hos myndigheten (datapolicy); och 2. En öppen licens för vidareutnyttjande av information från

In 1975 Mozambique attained its independence from Portugal, but it was only in 1992 with the establishment of a peace agreement after the extended civil war that the country was able to initiate its development process including the undertaking of research and development (R & D) efforts. Government and international cooperation provided the support for the R & D programmes and projects, m

Popular Abstract in Swedish Vilket lands domstolar är behöriga att lösa tvister som kan uppkomma till följd av elektroniska avtal där parterna hör hemma i olika länder? Vilket lands lag skall domstolen använda? Även om en svensk domstol är behörig är det inte säkert att den skall använda svensk lag. Dessa frågor sorterar inom ett ämnesområde som heter interationell privat- och processrätt. I avhanThis study addresses some of the private international law perspectives on electronic commerce, namely the matters of jurisdiction and choice of law. Electronic commerce is based on the formation of contracts, and when there are contracts, questions regarding legal issues arise. A distinctive trait of electronic business is that its activities are not bound by geographic borders in a traditional s

The Kruppel-like protein ZNF224 is a co-factor of the Wilms' tumor 1 protein, WT1. We have previously shown that ZNF224 exerts a specific proapoptotic role in chronic myelogenous leukemia (CML) K562 cells and contributes to cytosine arabinoside-induced apoptosis, by modulating WT1-dependent transcription of apoptotic genes. Here we demonstrate that ZNF224 gene expression is down-regulated both in

An electrochemical biosensor based on ZnO nanorods for potentiometric cholesterol determination is proposed. Hexagon-shaped ZnO nanorods were directly grown on a silver wire having a diameter of 250 mu m using low temperature aqueous chemical approach that produced ZnO nanorods with a diameter of 125250 nm and a length of similar to 1 mu m. Cholesterol oxidase (ChOx) was immobilized by a physical

The effect on a model drug delivery system when adding a drug, lidocaine, has been studied. Temperature and concentration dependence of a nonionic microemulsion with part of the oil, 1 and 10 vol. %, substituted with drug has been investigated. A nonionic oil-in-water microemulsion consisting of CH3(CH2)(11)(OCH2CH2)(5)OH, (C12E5), decane, water and the drug (lidocaine) that has been used to subst