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929 Proficiency Testing of Human Leukocyte Antigen-DR and Human Leukocyte Antigen-DQ Genetic Risk Assessment for Type 1 Diabetes Using Dried Blood Spots Paul Dantonio, M.S.,1 Nancy Meredith-Molloy, B.S.M.T., M.T.(ASCP),1 William A. Hagopian, M.D., Ph.D.,2 Jin Xiong She, M.D., Ph.D.,3 Beena Akolkar, Ph.D.,4 Suzanne K. Cordovado, Ph.D.,1 Miyono Hendrix, B.S.,1 L. Omar Henderson, PhD.,1 W. Harry Hann

https://www.teddy.lu.se/sites/teddy.lu.se/files/06032016_679_08_dantonio_jdst_2010.pdf - 2026-06-30

Genome editing has proven to be highly potent in the generation of functional gene knockouts in dividing cells. In the CNS however, efficient technologies to repair sequences are yet to materialize. Reprogramming on the mRNA level is an attractive alternative as it provides means to perform in situ editing of coding sequences without nuclease dependency. Furthermore, de novo sequences can be inser

Background: Diastolic dysfunction (DD) is increasingly common. However, its metabolic determinants are poorly known. This study aims to determine which metabolic and inflammatory features predict DD in initially healthy adults. Methods: We prospectively analyzed the association between metabolic features and DD in 728 initially healthy adults aged 30–60 from Eastern France enrolled in the STANISLA

Testicular germ cell cancer (TGCC) is the most common malignancy in young men. Genetic variants known to be associated with risk of TGCC only partially account for the observed familial risks. We aimed to identify additional polymorphisms associated with risk as well as histological and clinical features of TGCC in 367 patients and 214 controls. Polymorphisms in ESR2 (rs1256063; OR=0.53, 95% CI: 0

Antimicrobial peptides are important effector molecules of the innate immune system. Here, we describe that peptides derived from the heparin-binding disulfide-constrained loop region of human ß-amyloid precursor protein are antimicrobial. The peptides investigated were linear and cyclic forms of NWCKRGRKQCKTHPH (NWC15) as well as the cyclic form comprising the C-terminal hydrophobic amino acid ex

The present research was focused on the phytochemical research of Bolivian plants; a) two medicinal ones Aniba canelilla and Iryanthera juruensis, both plants showed to have compounds with biological activity in different fields. Even though Aniba canelilla was studied before, new compounds were identified in this investigation. The different active compounds found in Iryanthera juruensis seems to

Gaia Near InfraRed, or GaiaNIR for short, is a proposed successor to the original Gaia satellite. Its main improvement over the Gaia satellite is the fact that GaiaNIR will observe in the infrared spectrum. This would allow the telescope to see through the heavy extinction of the Milky Way, as the interstellar gas and dust obstructs light mainly in the visible spectrum. A selection function utiliz

This thesis explores the classification of savannah trees using EnMAP hyperspectral and Sentinel-2 multispectral satellite data using a Random Forest classifier. The study aimed to assess if the increase in spectral information from the hyperspectral data gives an increase in classification performance, to find the advantages and limitations to hyperspectral data compared to multispectral data and

Due to the civil war in Yemen, a Saudi-led operation was established on 26 March 2015 in Yemeni territory. The intervention, called "Operation Decisive Storm," was legitimized by the UN as a military intervention at the request of Yemeni President Abdrabuh Mansour Hadi. This thesis aims to examine the grounds on which Operation Decisive Storm has justified and the underlying factors that

Migrating birds are believed to minimize the time spent on migration rather than energy. Birds seem to maximize migration speed in different ways as a noteworthy variation in migration strategies exists. We studied migration strategies of a flight mode and feeding generalist, the Lesser Black-backed Gull Larus fuscus, using GPS-based satellite telemetry. We expected the gulls to achieve very high

To identify prognostic factors after hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). We retrospectively reviewed the combined experience at Toronto General Hospital and Hospital Vall d'Hebron managing HCC recurrence after LT (n = 121) between 2000 and 2012. We analyzed prognostic factors by uni- and multi-variate analysis. Median follow-up from LT was 29.5 (range 2-129.

BACKGROUND: There is an increasing interest in cognitive and functional outcomes in the respective stages of Alzheimer's disease (AD) and in novel therapies particularly for the milder phases of AD. Our aim was to describe and compare various aspects of disease progression in patients with mild versus moderate AD in routine clinical practice of cholinesterase inhibitor (ChEI) therapy. METHODS: Thi

Emulsion is a novel technique to deliver fats and fat soluble compounds in food, pharmaceuticals and cosmetic products. Different emulsifiers are often used to stabilize the emulsions. Chemically modified quinoa starch granule has taken research importance as an emulsifier in last decade. Chemically modified starch stabilized emulsions are now also been dehydrated to facilitate its use multidimens

The neurocognitive outcome of children born with extremely low birth weight (ELBW) is highly variable due to the complexity of morbidity. So far, no study has compared comprehensive neuropsychological test profiles in groups with different neuromotor status. In a national cohort of ELBW children neuropsychological test profiles were assessed in 4 groups defined according to a neurological examinat

Popular Abstract in Swedish Interaktionen mellan laddade polyjoner och motsatt laddade tensid joner har undersökts. Detta har gjorts genom att syntetisera det komplexa saltet (polyjon-tensid jon) och använda detta som utgångspunkt. Olika parametrar för det komplexa saltet har varierats systematiskt och effekten på struktur och vattenupptag har undersökts. Komplexa salt (CxTAPAy) bestående av alkylThe interaction between poylions and oppositely charged surfactant ions has been investigated. This has been done by using the pure complex salt (polyion + surfactant ion) as a point of departure. Different parameters of the complex salt have been varied in a systematic way and the effect on structure and water miscibility has been investigated. Complex salts (CxTAPAy) consisting of alkyl trimethy

The book contains the first part of an investigation aimed at finding out why it is morally wrong (at least prima facie) to cause species to go extinct. That it is morally wrong seems to be a very basic and widely held intuition. It seems reasonable that a moral theory worth taking seriously ought to be able to account for that intuition. The most common attempt to answer our question is to refer

The Hampshire breed was introduced as the terminal sire in Swedish slaughter pigs in the 1970s, mainly to reduce stress susceptibility and associated problems of meat quality, such as the meat being pale, soft and exudative (PSE). Since then, however, the RN – allele, a mutation which is only found in pure-bred Hampshire and in crosses with it, has been discovered. In Sweden, approximately 65% of

Popular Abstract in Swedish Enzymer är viktiga ämnen i naturen. Vi talar då och då om att vi förbränner vår mat. Trots detta känner vi oss oftast inte särskilt varma, i alla fall inte så att det bränns. Visst bränner vi vår mat. Socker omvandlas till koldioxid och vatten precis som om vi hade eldat upp det utanför kroppen. Skillnanden är att kroppen omvandlar sockret långsammare och mer kontrollerWith the goal to study the mechanisms of dinuclear metalloenzymes, a new line of synthetic and computational models were prepared and studied. Mixed imidazole and carboxylate multidentate complexes were synthesized to better simulate carboxylate-rich ligand environments. Of the compounds, which showed to be the most useful, were one symmetric and the other one asymmetric and in both cases they wer

Popular Abstract in Swedish I Big Bang, då vårt Universum skapades, bildades i princip endast de två lättaste grundämnena, väte och helium. Alla andra grundämnen har skapats, och skapas fortfarande, i olika typer av stjärnor under olika utvecklingsfaser. Detta betyder att precis alla atomer, förutom väte och helium, som bygger upp alla saker, växter, djur och människor i vår omgivning, har bildatsDisregarding the small primordial traces of the lightest elements, all metals have been formed in stellar processes, which means that the relative amount of metals in the Universe increases for every stellar generation. This build-up of elements is called chemical evolution and might be used both to constrain stellar models as well as understanding the formation and evolution of stellar population

We report a novel approach for single-shot planar imaging of CH3 radicals in premixed methane and air flames. A 213 nm beam from the 5th harmonic of an Nd:YAG laser was resonantly absorbed by the CH3 radicals, which were excited to the highly pre-dissociative upper level and dissociated to H2 and CH (X), as the main dissociation channel. The CH radicals were consequently excited by a 388 nm beam f