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Alternative analyses for handling incomplete follow-up in the intention-to-treat analysis: the randomized controlled trial of balloon kyphoplasty versus non-surgical care for vertebral compression fracture (FREE)
Background: Clinical trial participants may be temporarily absent or withdraw from trials, leading to missing data. In intention-to-treat (ITT) analyses, several approaches are used for handling the missing information - complete case (CC) analysis, mixed-effects model (MM) analysis, last observation carried forward (LOCF) and multiple imputation (MI). This report discusses the consequences of app
Extraction of water-soluble xylan from wheat bran and utilization of enzymatically produced xylooligosaccharides by Lactobacillus, Bifidobacterium and Weissella spp.
Xylan was extracted from wheat bran after heat pretreatment in water using either an autoclave or a microwave oven. Xylooligosaccharides (XOS) were produced from the xylan using the thermostable xylanase RmXyn10A and the potential prebiotic properties of XOS were studied in vitro with different human gut bacteria: Lactobacillus brevis (DSMZ 1269), Bifidobacterium adolescentis (ATCC 15703) and two
Muscle function and physical activity in pre-pubertal school children
Popular Abstract in Swedish Bakgrund: Regelbunden fysisk aktivitet och träning anses som en livsstilsfaktor som kan förbättra muskelstyrkan, skelettet, konditionen och kroppssammansättningen. För barn och ungdomar är fysisk aktivitet inte bara viktigt för att träna de muskulära funktionerna, koordinationen och balansen. I ett större perspektiv kan en fysiskt aktiv livsstil också minska risken för Background: Regular participation in physical activity or organized exercise is regarded as one important lifestyle factor that could improve musculoskeletal health, fitness and body composition. For children and adolescents physical activity is important not only in training of the neuromuscular system, coordination and balance, but in a wider perspective, for adopting a lifestyle that possibly r
Molecular Epidemiology of Metallo-beta-Lactamase-Producing Pseudomonas aeruginosa Isolates from Norway and Sweden Shows Import of International Clones and Local Clonal Expansion
Scandinavia is considered a region with a low prevalence of antimicrobial resistance. However, the number dof multidrug-resistant (MDR) Gram-negative bacteria is increasing, including metallo-beta-lactamase (MBL)-producing Pseudomonas aeruginosa. In this study MBL-producing P. aeruginosa isolates identified in Norway (n = 4) and Sweden (n = 9) from 1999 to 2007 were characterized. Two internationa
Complications to Cerebrospinal Fluid Drainage and Predictors of Spinal Cord Ischemia in Patients With Aortic Disease Undergoing Advanced Endovascular Therapy
Objective: To study the complications after cerebrospinal fluid (CSF) drainage and predictors of spinal cord ischemia (SCI) after advanced endovascular therapy with CSF drainage for complex aortic disease. Methods: Between 2009 and 2012, 88 attempts of CSF drainage insertions/84 operations/83 patients, of the 658 operations for aortoiliac diseases, were performed. Results: Indications for therapy
Cystatin C as a predictor of all-cause mortality and myocardial infarction in patients with non-ST-elevation acute coronary syndrome
Objectives: To investigate the predictive value of cystatin C among patients diagnosed with non-ST-elevation acute coronary syndrome (nSTE-ACS). Design and methods: Admission serum samples from 245 nSTE-ACS patients were measured with a novel cystatin C immunoassay based on a dry-reagent, double monoclonal design. Creatinine concentrations, estimated glomerular filtration rates (eGFR) and one-year
Systematics of Pipizini and taxonomy of European Pipiza Fallen: molecular and morphological evidence (Diptera, Syrphidae)
Vuji, A., Stahls, G., Aanski, J., Bartsch, H., Bygebjerg, R. & Stefanovi, A. (2013). Systematics of Pipizini and taxonomy of European Pipiza Fallen: molecular and morphological evidence (Diptera, Syrphidae). Zoologica Scripta, 42, 288305. In the present work the monophyly and molecular phylogenetic relationships of the genera of tribe Pipizini (Syrphidae) were investigated based on mitochondri
Deletions of IKZF1 and SPRED1 are associated with poor prognosis in a population-based series of pediatric B-cell precursor acute lymphoblastic leukemia diagnosed between 1992 and 2011.
Despite the favorable prognosis of childhood acute lymphoblastic leukemia (ALL), a substantial subset of patients relapses. Since this occurs not only in the high risk but also in the standard/intermediate groups, the presently used risk stratification is suboptimal. The underlying mechanisms for treatment failure include presence of genetic changes causing insensitivity to the therapy administere
Functional Data Analysis of Tongue Articulation in Palatal Vowels: Gothenburg and Malmöhus Swedish /i:, y:, u-:/
This study used Functional Data Analysis (FDA) to analyse tongue articulation dynamics, more specifically the height and frontness of the tongue body and tip in the palatal vowels /i:, y:, u-:/ of two varieties of Swedish. Articulatory data were collected from nine speakers each of Gothenburg and Malmöhus Swedish. Standard z-score transformations were used for speaker normalisation. Results showed
Functional data analysis of tongue articulation in Gothenburg and Malmöhus Swedish /i:, y:, u-:/
Articulatory data collected from nine speakers each of Gothenburg and Malmöhus Swedish were used in a Functional Data Analysis (FDA) to study tongue articulation dynamics, more specifically the height and frontness of the tongue body and tip in the palatal vowels /i ̆, y ̆, u̟ ̆/. Standard z-score transformations were used for speaker normalisation. Results showed that the tongue articulation for
Atlas of the Global Burden of Stroke (1990-2013): The GBD 2013 Study
Background: World mapping is an important tool to visualize stroke burden and its trends in various regions and countries. Objectives: To show geographic patterns of incidence, prevalence, mortality, disability-adjusted life years (DALYs) and years lived with disability (YLDs) and their trends for ischemic stroke and hemorrhagic stroke in the world for 1990-2013. Methodology: Stroke incidence, pre
Specific cysteine protease inhibitors act as deterrents of western flower thrips, Frankliniella occidentalis (Pergande), in transgenic potato
In this study, the effects of the accumulation of cysteine protease inhibitors on the food preferences of adult female western flower thrips, Frankliniella occidentalis (Pergande), were investigated. Representative members of the cystatin and thyropin gene families (stefin A, cystatin C, kininogen domain 3 and equistatin) were expressed in potato (Solanum tuberosum) cv. Impala, Kondor and Line V p
A description of some aspects of the triangular meeting between immigrant patients, their interpreters and GPs in primary health care in Stockholm, Sweden
Objectives. The first aim was to describe some aspects of each of the three perspectives in the triangular meeting between immigrant patients, interpreters and GPs, including their experiences, reflections and interactions during the consultation in primary health care. The second aim was to analyse patients' satisfaction with the consultation; whether satisfaction is influenced by respect for pat
Genetic variation and clonal diversity in four clonal sedges (Carex) along the Arctic coast of Eurasia
We studied the structure of genetic variation (at both ramet- and genet-level) and clonal diversity within and among populations in the four closely related arctic clonal sedges Carex bigelowii, C. ensifolia, C. lugens and C. starts by use of allozyme markers. Compared to other sedges and arctic plants, the studied taxa all had high levels of genetic variation, both within populations and taxa. Th
Antibody responses to borrelia IR6 peptide variants and the C6 peptide in Swedish patients with erythema migrans
The aim of this study was to evaluate the antibody responses to different VIsE protein IR6 peptide variants and the synthetic C6 peptide in acute and convalescent (2-3 and 6 months) serum samples from Swedish patients with clinical erythema migrans (EM). Serum samples were prospectively collected from 148 patients with EM and compared to serum samples obtained from 200 healthy blood donors. The Ig
Chronic hyperbaric exposure activates proinflammatory mediators in humans
Decompression illness (DCI) is an illness affecting divers subjected to reductions in ambient pressure. Besides a mechanical explanation to DCI, an inflammatory mechanism has been suggested. In this study, levels of interleukin (IL)-8, IL-6, IL-1 receptor antagonist (IL-1ra), secretory leukocyte protease inhibitor (SLPI), and neutrophil gelatinase-associated lipocalcin (NGAL) were measured in dive
Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas
The chromosomal translocation t(X;18)(p11.2;q11.2) is tightly linked to the tumorigenesis of synovial sarcoma. Through this translation the SYT gene on chromosome 18 is fused with a testis/cancer antigen gene on the X chromosome, generating either a SYT-SSX1, SYT-SSX2, or less often a SYT-SSX4 fusion gene. It has been anticipated that the individual synovial sarcoma carries only one of these varia
