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Objective: To characterise distinctive clinical features of giant prolactinomas in women. Design: A multicentre, retrospective case series and literature review. Methods: We collected data from 15 female patients with a pituitary tumour larger than 4 cm and prolactin levels above 1000 mu g/l and identified 19 similar cases from the literature; a gender-based comparison of the frequency and age dis
In ST-elevation myocardial infarction (STEMI), thrombus material is often present in partial or total coronary occlusion of the coronary vessel. However, prior to the thrombus aspiration during ST-Segment Elevation Myocardial Infarction in Scandinavia (TASTE) trial, it remained unclear whether routine thrombus aspiration during percutaneous coronary intervention (PCI) treatment of STEMI would resu
Studying gene-lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene-lifestyle studies are lacking. This case-cohort study aims to investigate how genetic and potentially modifiable
Context:Patients with hypopituitarism have an increased standardized mortality rate. The basis for this has not been fully clarified.Objective:To investigate in detail the cause of death in a large cohort of patients with hypopituitarism subjected to long-term follow-up.Design and Methods:All-cause and cause-specific mortality in 1286 Swedish patients with hypopituitarism prospectively monitored i
Context. Spectral-line asymmetries (displayed as bisectors) and wavelength shifts are signatures of the hydrodynamics in solar and stellar atmospheres. Theory may precisely predict idealized lines, but accuracies in real observed spectra are limited by blends, few suitable lines, imprecise laboratory wavelengths, and instrumental imperfections. Aims. We extract bisectors and shifts until the "ulti
Describing the biotic and abiotic processes that are responsible for the formation of spatial patterns in predators and their prey is crucial for improving our understanding of food-web interactions. We studied the spatial distribution of four abundant spider species and three common groups of epedaphic Collembola prey in a beech-dominated (Fagus sylvatica) forest floor habitat and related the obs
Objective:. The aim of this study was to describe the variation of soy product intake in 10 European-countries by using a standardised reference dietary method. A subsidiary aim was to characterise the pattern of soy consumption among a sub-group of participants with a habitual health-conscious lifestyle (HHL), i.e. non-meat eaters who are fish eaters, vegetarians and vegans. Design: A 24-hour die
Purpose Randomized clinical trials can provide strong evidence regarding effective treatment options. The quality of reporting and the type of outcome measures used are important when judging whether results justify change in clinical practice. The aim of this study was to assess the quality of reporting of randomized clinical trials related to treatment of upper-extremity disorders, published in
This population-based register study examined if factors during the fetal and neonatal period influence the risk for the child to develop bronchial asthma (asthma). From the Swedish Hospital Discharge Register we identified children, born between 1987 and 1999, who had been hospitalized for asthma up to 2001. Thus, the outcome measure contains only hospitalized cases, not all children with asthma.
Pigs of the same genetic type at the RN and HAL loci, i.e. rn(+) RN-/NN were reared in similar conditions of feeding and housing. They were slaughtered in two abattoirs (referred to as A1 and A2) using a mixture of air (30%) and CO2 (70%), at a rate of 300 pigs per hour per slaughterline. One hundred and thirty-two pigs from I I farms were slaughtered in A I using a corusinga restrainer and 127 pi
Background. An altered renal function is an essential component of the patho-physiology of pre-eclampsia. The plasma levels of low molecular mass proteins, e. g. beta-trace protein, beta-2-microglobulin and cystatin C, are increased in the third trimester of normal pregnancy. The plasma levels of cystatin C and beta-2-microglobulin are further increased in preeclampsia, and the cystatin C level ha
This study aimed to evaluate the association between objectively measured habitual physical activity and calcaneal and forearm bone mineral density (BMD, g/cm(2)), one mechanically more loaded and one less loaded skeletal region, in children aged 6-8 years. BMD was measured in 297 boys and 265 girls by peripheral dual-energy X-ray absorptiometry in the forearm and calcaneus. An accelerometer regis
The insulin-like growth factor (IGF) system demonstrates numerous actions during neoplastic growth and is therefore an interesting target with potential clinical implications. While numerous studies have established important roles of the IGF system in regulating cellular growth and survival of several tumor forms, very limited reports exist regarding its role in renal cell carcinoma (RCC). The ai
Popular Abstract in Swedish Syftet med denna avhandling är att analysera och förklara den institutionella förändringen vad gäller läkemedelsförsäljning i Sverige. Avhandlingens bidrag är studier av denna specifika institutionella utveckling där nyinstitutionell ekonomisk teori har använts för att undersöka drivkrafterna. Avhandlingen består av tre artiklar. Syftet med den första artikeln är att beThe aim of this thesis is to analyze and to explain the institutional change in the provision of pharmaceuticals in Sweden. The thesis’ contribution is studies of this specific institutional development. New Institutional Economic theory is used to scrutinize the driving forces of this development. The thesis consist of three papers. The purpose of the first paper is to discuss and to analyze the
Introduction: Fenestrated aortic stent-grafts are increasingly being used to treat patients with juxtarenal abdominal aortic aneurysms (AM). Sizing of these stent-grafts is critical to ensure success and requires detailed expert assessment of aortic morphology. At present little is known about how sizing of these stent-grafts varies between observers and the necessary tolerances involved to ensure
Background: Continuous abstinence and retention in treatment for alcohol and drug use disorders are central challenges for the treatment providers. The literature has failed to show consistent, strong predictors of retention. Predictors and treatment structure may differ across treatment modalities. In this study the structure was reinforced by the addition of supervised urine samples three times
Popular Abstract in Swedish Kultursemiotiken studerar möten mellan kulturer. Begreppen Kultur, Extra-kultur och Icke-kultur utvecklades av Tartuskolan under 1970-talet, och användes i deras studier av den ryska kulturen och dess relation till Västeuropa. Särskild vikt lades vid Peter den Stores försök att göra Ryssland mer likt Väst. Målet med denna avhandling i kultursemiotik är att vidareutvecklCultural semiotics studies encounters between cultures. Notions such as Culture, Extra-culture and Non-culture were developed in the 1970s by the Tartu school and were used in their studies of Russian culture and its relation to Western Europe, with special focus on Peter the Great's attempt to Westernize Russia in the eighteenth century. The aim of this dissertation in cultural semiotics is to fu
