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G-protein-regulated inward-rectifier potassium channel 2 (GIRK2) is reported to be expressed only within certain dopamine neurons of the substantia nigra (SN), although very limited data are available in humans. We examined the localization of GIRK2 in the SN and adjacent ventral tegmental area (VTA) of humans and mice by using either neuromelanin pigment or immunolabeling with tyrosine hydroxylas
Objective: Osteoarthritis (OA) is a common degenerative disease with a genetic contribution. However, no large nationwide family study concerning the heredity of OA has been published. This first nationwide study aimed to determine the familial risks of the main types of OA in twins, full-siblings, half-siblings, and cousins in Sweden. Design: The Swedish Multigeneration register was linked to the
Title: What drives the customer's choice of packaging and which factors influence the customer's packaging cost? ? in the automotive and manufacturing industries Author: Lena Andersson Supervisors: Annika Olsson, Division of Packaging Logistics, Lund Institute of Technology Helena Claesson, Volvo Logistics AB Problem: Which parameters are important for logistic people to think of when
More than 2,5 million people have been displaced from their homes and over 200.000 people have been killed since the conflict in Darfur, a western providence of Sudan, escalated in 2003. The international community has again failed to prevent a humanitarian crisis and protect the civilians even though strong evidence of ethnic cleansing and genocide performed by the government in Sudan and its Ara
Ladyfest Sweden is a cultural festival which aims to create a cultural space of expression for women, thus the artists and the organizers are women. It is organized by three different groups in three different cities: Malmö, Stockholm and Göteborg. This thesis is focused on Ladyfest Malmö, all the field work being realized with this group. We tried to include this phenomenon in a global and a part
The current curriculum requires a well functioning school library and an active use of it. In junior school grades 1-3 the children primarily learn basic skills. Knowledge about libraries and how to use them and different media is part of these skills. Therefore my intention was to investigate how school libraries in junior schools look, how they are used in the training and how they could be used
In this essay we aim at finding an appropriate flash estimator of the quarterly Swedish private consumption (PK). With the aid of the statistics program TRAMO we study if monthly data from the consumer survey (HIP) and retail industry (DH) can be used in a transfer function model (TFM) to forecast PK. In the work of assessing the state of the market and the business trend, fast information from th
The main aim of the thesis is, first, to present a theoretical and methodological perspective for the study of postmodern theory in historiography; second, to discuss and evaluate earlier research on the subject; and third, to show that historians must be more self-reflexive about their explicit as well as implicit theoretical and philosphical premises. My theoretical and methodological inspiratio
The International Criminal Tribunals for the Former Yugoslavia and for Rwanda symbolise the commitment of the international community to put an end to impunity and to reintroduce justice and due process where it has long been denied. With the addition of the Special Court for Sierra Leone and the International Criminal Court international criminal justice has developed into a permanent feature of
Study Design. The Swedish patients included in the previous SRS brace study were invited to take part in a long-term follow-up. Objective. To investigate the rate of scoliosis surgery and progression of curves from baseline as well as after maturity. Summary of Background Data. Brace treatment was shown to be superior to electrical muscle stimulation, as well as observation alone, in the original
STUDY DESIGN. Symptomatic patients were retrospectively analyzed and compared with a control group from an ongoing prospective and consecutive study. OBJECTIVES. To determine the presence and extent of epidural fibrosis in patients with and without recurrent sciatic pain after previous lumbar discectomy, contrast-enhanced magnetic resonance images were evaluated and correlated with surgical findin
Popular Abstract in Swedish Streptococcus pyogenes (GAS) är en viktig sjukdomsframkallande bakterie som orsakar alltifrån lindriga infektioner som halsfluss (tonsillit) och svinkoppar (impetigo) till livshotande djupa infektioner som nekrotiserande fasceit eller ”Toxic shock syndrom”. På grund av det snabba sjukdomsförloppet i de livshotande infektionerna har streptokockerna fått beteckningen ”mörA distinguishing feature of Streptococcus pyogenes (GAS) is their ability to resist phagocytosis in whole human blood in the absence of type-specific antibodies, a property that is dependent on the expression of the surface associated M proteins. A common characteristic of M proteins is their interaction with a variety of host proteins including the complement regulatory protein factor H (FH) and
Popular Abstract in Undetermined Denne afhandling præsenterer en ny udlæsnings metode udviklet til cantileverbaserede sensorer. Cantilevere er tynde vipper, der er fastgjorte i den ene ende, og som igennem de seneste ti °ar har vist sig at være en interessant ny type bio/kemisk sensor. Den specifikke genkendelse af et kemikalie viser sig ved at cantileveren bøjer som følge af det skabte overfladesThis thesis presents a novel read-out method developed for cantilever-based sensors. Cantilevers are thin beams clamped at one end and during the last 10 years they have emerged as an interesting new type of bio/chemical sensor. The specific recognition of a chemical manifests itself as a bending of the cantilever from the generated surface stress. Conventionally the read-out used for this type of
Background: Variation in the 10 toll-like receptor (TLR) genes has been significantly associated with allergic rhinitis (AR) in several candidate gene studies and three large genome-wide association studies. These have all investigated common variants, but no investigations for rare variants (MAF≤1%) have been made in AR. The present study aims to describe the genetic variation of the promoter and
Syftet med studien är att undersöka den förbättrade upptagningen av det radioaktiva spåret Technetium-99m-DTPA (99mTc-DTPA) i råtta Muskelvävnad i Fischer 344 råttor efter applicerade elektriska pulser av olikafältstyrka och pulslängd,Metoder: 99mTc-DTPA (totalt 150 MBq) administrerades intramuskulärt (i.m.) vid axelnsom en bolus i flera fraktioner om 50 l var och en i intervaller på 1 minut. Bil
Svensk sammanfattningAvhandlingens syfte har varit att studera utvecklingen av en könskromosom i realtid genom att simulera dess framväxt i en hermafroditisk plattmask i laboratoriet. Jag gjorde detta genom att selektera på dels honlig fitness (fitness via ägg), dels hanlig fitness (fitness via spermier) med hjälp av en genetisk markör, som agerade som en könsbestämmande gen. Detta ska efterlikna Sex chromosome evolution in a hermaphrodite ancestor starts with the establishment of a sex-determining region (SDR). Over time, sex-specific genes, and/or sexually antagonistic alleles will become linked to the SDR. Sexually antagonistic alleles are a type of genetic variation that increases fitness for one sex while being detrimental for the other sex. Recombination arrest around the SDR and gen
