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Purpose: Alpha-synuclein often co-occurs with Alzheimer's disease (AD) pathology in Dementia with Lewy Bodies (DLB). From a dynamic [18F]flortaucipir PET scan we derived measures of both tau binding and relative cerebral blood flow (rCBF). We tested whether regional tau binding or rCBF differed between DLB patients and AD patients and controls and examined their association with clinical character
Background: Infectious complications in ANCA associated vasculitis (AAV) are a major cause of morbidity and mortality. The aim of this study was to determine the incidence rates, predictors and outcome of severe infections in AAV. Methods: We conducted a population-based cohort study in Southern Sweden with 326 incident cases of AAV diagnosed between 1997 and 2016. Diagnosis of vasculitis was conf
EU countries have committed to taking national measures to reduce the average energy use of residential buildings by 16% by 2030 and 20–22% by 2035. Each country has decided how to achieve this and which buildings to focus on. However, certain categories of residential buildings, including historical buildings but also second homes, may be exempt from these obligations. In Sweden, second homes con
Background and objective: Guideline recommendations regarding early management of grade group (GG) 2 prostate cancer with confirmatory biopsy (cBx) are not well established. Our aim was to determine which patients with GG 2 cancer should undergo cBx before treatment decision-making by evaluating the probability of downgrading to GG 1 or no cancer on cBx. Methods: This was a single-institution retr
This performance lecture dealt with plan b's ongoing practice of twenty years of collecting personal data, which has been the basis for a number of art works and performances over the years. As artists, educators and researchers, we have deliberately intermingled our art and life, be it through collecting GPS traces of everywhere we go or shouting all our text messages to one another. For us, the
Cracks in concrete compromise structural integrity by exposing steel reinforcement to corrosion agents, shortening its service life. Fungal-induced calcium carbonate (CaCO3) precipitation via urea hydrolysis offers a fast and robust self-healing mechanism to seal the cracks, extending the lifespan while reducing the carbon (C) footprint of concrete infrastructure. However, current studies rely on
Background: The choice of rhythm control drugs for recurrent atrial fibrillation (AF) remains empirical and is based on the safety profile rather than predicted efficacy. Flecainide is recommended for prevention of AF recurrence in patients without structural heart disease however predictors of treatment success are insufficiently studied. Objective: To assess clinical characteristics associated w
Background World economies increasingly rely on non-standard employment arrangements, which has been linked to ill health. While work and employment conditions are recognized structural determinants of health and health equity, policies aiming to protect workers from negative implications predominantly focus on standard employment arrangements and the needs of workers in non-standard employment ma
AIMS: We aimed to investigate major adverse cardiac events (MACE: defined as all-cause mortality, re-infarction, and stroke), length of hospital stays (LOS), and comorbidities following acute coronary syndrome (ACS) in a population with schizophrenia.METHODS AND RESULTS: This Danish register study included patients diagnosed with ACS in the period between 1995 and 2013 with a preceding diagnosis o
Background Increased postoperative cardiac troponin (cTn) independently predicts short-term mortality. Previous studies suggest that preoperative cTn also predicts major adverse cardiovascular events (MACE) and mortality after noncardiac surgery. The value of preoperative and perioperative changes in cTn as a prognostic tool for adverse outcomes has been sparsely investigated. Methods and findings
Introduction: To remain competitive, industrial organisations are continually faced with the challenges to improve product quality, reduce product development time, reduce production costs and lead-times. Increasingly, these challenges cannot be effectively met by isolated changes to specific organizational units. The Supply Chainis a revolutionary concept embedded in a traditional guise. In b
In this project, we are studying the material flow and the information flow of sample materials and the appurtenant report of deviation for the purpose to be able to suggest better solutions. The sample material, which is to be analysed, is to be continuously taken from the production flow. The purpose is to navigate the process by the results found by the analysis. Because of this, it's very
Purpose: The purpose of this thesis is to identify and analyze innovative products and services within the telecom industry, letting these findings constitute possible ways for CSPs to innovate the experience of their customers. Methodology: The research in this thesis was conducted from a qualitative approach and data were collected using primary- (expert interviews) and secondary sources (journa
A rapid shift from traditional Sanger sequencing-based molecular methods to the phylogenomic approach with large numbers of loci is underway. Among phylogenomic methods, restriction site associated DNA (RAD) sequencing approaches have gained much attention as they enable rapid generation of up to thousands of loci randomly scattered across the genome and are suitable for nonmodel species. RAD data
Objective: To describe the design and rationale for the genetic analysis of acute and chronic cerebrovascular neuroimaging phenotypes detected on clinical MRI in patients with acute ischemic stroke (AIS) within the scope of the MRI-GENetics Interface Exploration (MRI-GENIE) study. Methods: MRI-GENIE capitalizes on the existing infrastructure of the Stroke Genetics Network (SiGN). In total, 12 inte
Historically, treatment based on the availability of clotting factor replacement has resulted in an arcane guideline for the correction of factor deficiencies in people with haemophilia (PwH). While all other disease entities seek to restore function to a normal level, PwH are restricted to factor nadirs still equivalent to mild or moderate disease, resulting in continued risk of bleeding. A new t
Precise regulation of dNTPs within the cellular nucleotide pool is essential for high accuracy of DNA replication and is critical for retaining the genomic integrity. Recently, human dCTPase (deoxycytidine triphosphatase), also known as DCTPP1 (human all-alpha dCTP pyrophosphatase 1) has been revealed to be a key player in the balance of pyrimidine nucleotide concentrations within cells, with DCTP
BACKGROUND: In the Swedish population-based follow-up program and national quality registry for individuals with cerebral palsy (CPUP), physiotherapy (PT) and occupational therapy (OT) treatments are regularly recorded along with functional status. By Swedish law, all citizens irrespective of personal characteristics or socioeconomic status, have the right to receive healthcare and medical treatme
Accurate knowledge about the amount and dynamics of terrestrial gross primary productivity is an important component for understanding of ecosystem functioning and processes. Recently a new diagnostic model, Southampton Carbon Flux (SCARF), was developed to predict terrestrial gross primary productivity at regional to global scale based on a chlorophyll index derived from MERIS data. The model aim
Anthropogenic climate change has increased the frequency of extreme drought events and leads to “hotter” droughts. Topography controls plant available water and site-specific climatic conditions. Drought sensitivity may therefore vary over short distances between wet and dry locations of the landscape. However, topography is rarely included as a factor in research investigating vegetation dynamics
