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Results and recommendations from an intercomparison of six Hygroscopicity-TDMA systems

The performance of six custom-built Hygrocopicity-Tandem Differential Mobility Analyser (H-TDMA) systems was investigated in the frame of an international calibration and intercomparison workshop held in Leipzig, February 2006. The goal of the workshop was to harmonise H-TDMA measurements and develop recommendations for atmospheric measurements and their data evaluation. The H-TDMA systems were co

Characterization of mutations in barley fch2 encoding chlorophyllide a oxygenase

The barley (Hordeum vulgare L.) mutants fch2 and clo-f2 comprise an allelic group of 14 Chl b-deficient lines. The genetic map position of fch2 corresponds to the physical map position of the gene encoding chlorophyllide a oxygenase. This enzyme converts chlorophyllide a to chlorophyllide b and it is essential for Chl b biosynthesis. The fch2 and clo-f2 barley lines were shown to be mutated in the

Comparison of neuropsychological and brain imaging data in pediatric brain tumor patients surviving more than 10 years

AIM: To explore the relationship between neuropsychological outcome and magnetic resonance imaging (MRI) findings in paediatric brain tumour patients surviving more than 10 years. BACKGROUND: Cognitive late sequelae after paediatric brain tumour have a multifactorial origin. Low age at diagnosis, cranial radiation therapy, intrathecal methotrexate treatment and increased intracranial pressure are

Compensation for wind drift by migrating swifts

We investigated the orientation in relation to wind of common swifts, Apus apus, during nocturnal spring and autumn migration. Swifts are highly adapted to a life in the air, showing wind-dependent orientation during nocturnal roosting flights, and may be expected to be more efficient in their wind drift/compensation behaviour than nocturnal passerine migrants, which are usually subjected to full

Effects of predator specialization, host plant and climate on biological control of aphids by natural enemies: a meta-analysis

Aphids are among the most severe invertebrate pests of crops and cause high economic losses. The control of aphids by natural enemies is an essential ecosystem service with high relevance to management strategies applied in agricultural plant production and horticulture. However, the current knowledge on the effectiveness of specialist and generalist predators in aphid control with respect to host

Two-Year Survival Follow-Up of the Randomized, Double-Blind, Placebo-Controlled Phase II Study of Radium-223 Chloride in Patients With Castration-Resistant Prostate Cancer and Bone Metastases

In this 24-month follow-up of a phase II study in patients with castration-resistant prostate cancer (CRPC) and bone metastases, radium-223 (4 injections of 50 kBq/kg every 4 weeks [n = 33]) improved median overall survival vs. matching placebo (n = 31) (65.3 vs. 46.4 weeks, respectively; log-rank P = .056), with no long-term safety concerns. Data suggest that treatment of bone disease with radium

Growth Hormone Dose-Dependent Pubertal Growth: A Randomized Trial in Short Children with Low Growth Hormone Secretion

Background/Aims: Growth hormone (GH) treatment regimens do not account for the pubertal increase in endogenous GH secretion. This study assessed whether increasing the GH dose and/or frequency of administration improves pubertal height gain and adult height (AH) in children with low GH secretion during stimulation tests, i. e. idiopathic isolated GH deficiency. Methods: A multicenter, randomized,

Exploring public transport as an element of older persons' mobility: A Capability Approach perspective

This study employs Amartya Sen's Capability Approach as a guiding conceptual framework in the exploration of public transport as an element of mobility among the young-old living in Stockholm, Sweden. The aim is to shed light on the variation in mobility resources of those who perceive they can use public transport as their primary mode of transport and of those who perceive they cannot ('mobility

Aphids and their natural enemies are differently affected by habitat features at local and landscape scales

Biological control, an essential ecosystem service to agriculture, can be affected by ecological processes operating at landscape scales. Here we assessed the effect of landscape complexity, measured as proportion of arable land (PAL), on the abundance of aphids, parasitoids, and specialist and generalist predators. In addition we set up cage experiments to test the ability of these groups of enem

Evidence from Dwyka tillite cobbles of Archaean basement beneath the Kalahari sands of southern Africa

We have found a new source of information about what lies beneath the Kalahari sands. The Kheis and Rehoboth Provinces of southern Africa were thought to be underlain by either an similar to 1800 Ma orogenic belt, or a northern branch of the similar to 1200 Ma Namaqua-Natal Province. Glacial diamictites of the Permocarboniferous Dwyka Group exposed at Rietfontein west of the Kalahari sands carry c

LaCoO3: Promising cathode material for protonic ceramic fuel cells based on a BaCe0.2Zr0.7Y0.1O3-delta electrolyte

Symmetric cells (cathode/electrolyte/cathode) were prepared using BaCe0.2Zr0.7Y0.1O3-delta (BCZY27) as proton conducting electrolyte and LaCoO3 (LC) infiltrated into a porous BCZY27 backbone as cathode. Single phased LC was formed after annealing in air at 600 degrees C for 2 h. Scanning electron micrographs showed the presence of the infiltrated LC in the full cathode depth. Transmission electron

Optimal experimental design for filter exchange imaging: Apparent exchange rate measurements in the healthy brain and in intracranial tumors.

PURPOSE: Filter exchange imaging (FEXI) is sensitive to the rate of diffusional water exchange, which depends, eg, on the cell membrane permeability. The aim was to optimize and analyze the ability of FEXI to infer differences in the apparent exchange rate (AXR) in the brain between two populations.METHODS: A FEXI protocol was optimized for minimal measurement variance in the AXR. The AXR variance

Immobilisation of CGTase for continuous production of long-carbohydrate-chain alkyl glycosides Control of product distribution by flow rate adjustment

Bacillus macerans cyclodextrin glycosyltransferase (CGTase) (EC 2.4.1.19) was covalently immobilised on Eupergit C and used in a packed-bed reactor to investigate the continuous production of long-carbohydrate-chain alkyl glycosides from alpha-cyclodextrin (alpha-CD) and n-dodecyl-(1,4)-beta-maltopyranoside (C(12)G(2)beta). The effects of buffer ion strength and pH, and enzyme loading on the immob

Blood pressure levels and risk of cardiovascular events and mortality in type-2 diabetes: cohort study of 34 009 primary care patients.

OBJECTIVE:: The optimal blood pressure (BP) in persons with type-2 diabetes is debated. We investigated shapes of the associations of SBP and DBP levels with risk of cardiovascular events and mortality in a large primary care-based sample of diabetic patients. METHODS:: We investigated all 34 009 consecutive cardiovascular disease-free type-2 diabetes patients aged 35 years or older (mean age 64 y

International Development of the Unidimensional Fatigue Impact Scale (U-FIS)

Objective: The 22-item Unidimensional Fatigue Impact Scale (U-FIS) provides an index of the impact of fatigue on patients with multiple sclerosis (MS). The objective is to produce eight new language versions of the U-FIS: Canadian-English, Canadian-French, French, German, Italian, Spanish, Swedish, and US-English. Methods: The U-FIS was translated via two translation panels. Cognitive debriefing i

Entrapment of Living Bacterial Cells in Low-Concentration Silica Materials Preserves Cell Division and Promoter Regulation

The entrapment of bacterial cells within inorganic silica materials was reported almost 20 years ago. However, almost all studies to date have shown that these entrapped cells are unable to divide and thus should be expected to have reduced promoter activity. In view of the importance of bacteria as model systems for both fundamental and applied biological studies, it is crucial that immobilized c

Bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukaemia: updated results of a randomized phase III trial

The efficacy of bendamustine versus chlorambucil in a phase III trial of previously untreated patients with Binet stage B/C chronic lymphocytic leukaemia (CLL) was re-evaluated after a median observation time of 54months in May 2010. Overall survival (OS) was analysed for the first time. At follow-up, investigator-assessed complete response (CR) rate (21.0% vs 10.8%), median progression-free survi

Swedish birds are tracking temperature but not rainfall: evidence from a decade of abundance changes

Aim: To quantify avian distribution shifts and the extent of niche tracking in response to changing temperature and precipitation patterns. Location: Sweden. Methods: We used abundance monitoring data to quantify changes in bird species distributions between two time periods, 2000-02 and 2010-12. First we examined shifts at the level of whole distributions using population centroids in temperature

Association between autoantibodies to the Arginine variant of the Zinc transporter 8 (ZnT8) and stimulated C-peptide levels in Danish children and adolescents with newly diagnosed type 1 diabetes

Background The zinc transporter 8 (ZnT8) was recently identified as a common autoantigen in type 1 diabetes (T1D) and inclusion of ZnT8 autoantibodies (ZnT8Ab) was found to increase the diagnostic specificity of T1D. Objectives The main aims were to determine whether ZnT8Ab vary during follow-up 1 year after diagnosis, and to relate the reactivity of three types of ZnT8Ab to the residual stimulate

Disentangling the effects of land-use change, climate and CO2 on projected future European habitat types

AimTo project the potential European distribution of seven broad habitat categories (needle-leaved, broad-leaved, mixed and mediterranean forest, urban, grassland and cropland) in order to assess effects of land use, climate change and increase in CO2 on predicted habitat changes up to the year 2050. LocationEurope. MethodWe modelled the response of European vegetation to changes in land use, clim