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Real exposure to pig pancreatic juice and bile inhibit exocrine pancreatic secretion in pigs

The mechanisms involved in the down regulation of the exocrine pancreas are still not fully elucidated. The purpose of the present study was to examine the effect of duodenal and ileal exposure to pancreatic enzymes and bile on pancreatic secretion. Experiments were performed with pigs fitted with pancreatic duct, ileal and jugular vein catheters, and duodenal T-shaped cannula. A negative feedback

Medical proton dosimetry using radioluminescence from aluminium oxide crystals attached to optical-fiber cables

The prime objective of this study is to investigate if radioluminescence (RL) from carbon-doped aluminum oxide (Al2O3:C) crystals potentially can be used for absorbed dose-rate measurements during proton radiotherapy. The RL from two separate (2 mg) Al2O3:C crystals attached to optical-fiber cables were recorded during irradiations in water in a 175 MeV clinical proton beam. The RL response for lo

Pleural mesothelioma in Sweden: an analysis of the incidence according to the use of asbestos

OBJECTIVE: To investigate if the preventive measures taken to reduce the occupational exposure to asbestos have resulted in a decreased incidence of pleural mesothelioma in Sweden. METHODS: The incidence of pleural mesothelioma between 1958 and 1995 for birth cohorts born between 1885 and 1964 was investigated. The cases of pleural mesothelioma were identified through the Swedish Cancer Register.

Expression of bovine calmodulin in tobacco plants confers faster germination on saline media

Calmodulin is a Ca2+-dependent regulatory protein in eukaryotic cells involved in a variety of intracellular activities. Many responses to abiotic stresses involve signaling by Ca2+ and Ca2+/calmodulin regulation, including water and salinity stress. To investigate how calmodulin affects germination on media with high concentrations of NaCl, transgenic tobacco plants expressing heterologous calmod

Mutual enhancement of the current density and the coulombic efficiency for a bioanode by entrapping bi-enzymes with Os-complex modified electrodeposition paints

A bioanode with high current density and coulombic efficiency was developed by co-immobilization of pyranose dehydrogenase from Agaricus meleagris (AmPDH) with the dehydrogenase domain of cellobiose dehydrogenase from Corynascus thermophiles (recDHCtCDH) expressed recombinantly in Escherichia coli. The two enzymes were entrapped in Os-complex modified electrodeposition polymers (Os-EDPs) with spec

Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutations

Popular Abstract in Swedish Varje år insjuknar omkring 300 barn i cancer. Förbättrade behandlingsmetoder under de senaste decennierna har lett till att mer än tre av fyra barn idag faktiskt botas från sin sjukdom. Tyvärr drabbas en stor andel av de som överlever sin cancer av så kallade sena komplikationer till följd av den tuffa behandling de har utsatts för. Bland annat har man sett en livslång The etiology of childhood cancer is largely unknown. Approximately 1-10% of all childhood tumors are associated with known cancer predisposition syndromes. However, the contribution may be underestimated due to the failure to detect patients with genetic susceptibility for cancer when relying on known family pattern and anomalies. Growing evidence indicates that patients with genetic susceptibilit

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This paper is the state of the art of charcoal signal studies (macro-, meso- and micro-charcoal) that have been carried out at the Epigravettian settlement of Mezhyrich. This work took part of the French ANR project "Mammouths". Charcoal signals have been found in both natural and archaeological (pits and activity areas) deposits that have been sampled during the 2007-2008 archaeological excavatio

Role of Aromatic Side Chains in Amyloid β-Protein Aggregation.

Aggregation of the amyloid β-protein (Aβ) is believed to be involved in Alzheimer's disease pathogenesis. Here we have investigated the importance of the aromatic rings at positions 19 and 20 for the aggregation rate and mechanism by substituting phenylalanine with leucine. Aggregation kinetics were monitored as a function of time and peptide concentration by thioflavin T (ThT) fluorescence, the a

A mobile multi-depth borehole sensor set-up to study the surface-to-base seismic transfer functions

The best method to evaluate the seismic site response is by means of borehole vertical arrays that use earthquake records from different depths. In this paper we introduce the implementation of a single borehole sensor system (synchronized to a sensor on the surface) that is fixed at variable depths within a single well. This system is used for recording small amplitude earthquake signals at varia

Genotypes, haplotypes and diplotypes of three XPC polymorphisms in urinary-bladder cancer patients

Purpose The XPC gene is involved in DNA damage recognition in the nucleotide excision repair pathway (NER) We investigated the additive effects of single nucleotide polymorphisms (SNPs) in bladder-cancer patients and population controls for three XPC polymorphisms A499V (C>T) K939Q (A>C) and poly AT (PAT -/+) Experimental Design 311 bladder-cancer patients from a population-based cohort and 337 po

Health-related quality of life in Swedish children and adolescents with limb reduction deficiency

Aim: To investigate health-related quality of life (HRQoL) in young persons with limb reduction deficiency (LRD). Methods: One hundred and forty children with LRD aged 8-16 answered the DISABKIDS questionnaire for children with chronic health conditions. Of their parents, 137 answered a corresponding questionnaire concerning their child. Results: Compared to reference data from children with other

Discrepancies in pain presentation caused by adverse psychosocial conditions as compared to pain due to high physical workload?

Disorders in the musculoskeletal system have been associated with a high physical workload as well as psychosocial and individual factors. It is however not obvious which of these factors that is most important to prevent. Musculoskeletal disorders in neck and upper extremity was assessed by interview and clinical examination in 79 teachers and 93 assisting nurses, all females. Psychosocial work e

Midwives' awareness and experiences regarding domestic violence among pregnant women in southern Sweden

Objective: to explore midwives' awareness of and clinical experience regarding domestic violence among pregnant women in southern Sweden. Design: an inductive qualitative design, using focus groups interviews. Setting: midwives with experience of working in antenatal care (ANC) units connected to two university hospitals in southern Sweden. Participants 16 midwives recruited by network sampling an

An inherited variant in the gene coding for vitamin D-binding protein and survival from cutaneous melanoma: a BioGenoMEL study

An association between low serum vitamin D levels and poorer melanoma survival has been reported. We have studied inheritance of a polymorphism of the GC gene, rs2282679, coding for the vitamin D-binding protein, which is associated with lower serum levels of vitamin D, in a meta-analysis of 3137 melanoma patients. The aim was to investigate evidence for a causal relationship between vitamin D and

Effects of multidimensional treatment foster care (MTFC): Results from a RCT study in Sweden

This study examines 24-month post-baseline outcomes for a RCT study of Swedish antisocial youths who received either treatment in multidimensional treatment foster care (MTFC) or treatment as usual (TAU). MTFC, a community-based treatment program, has successfully treated chronic juvenile offenders in the USA This study is the second randomized control study in Sweden that includes MTFC. Compared

Pelagic-benthic coupling within an upwelling system of the subtropical northeast Atlantic over the last 35 ka BP

We present a high resolution, multiproxy study of the relationship between pelagic and benthic environments of a coastal upwelling system in the subtropical NE Atlantic Ocean. Marine sediments corresponding to late MIS3 to the Holocene in the radiocarbon dated core GeoB7926, retrieved off Mauritania (21 degrees N) were analysed to reconstruct productivity in surface waters and its linkage to deep

Improvement in time-domain induced polarization data quality with multi-electrode systems by separating current and potential cables

Measuring induced polarization in the time domain with relatively compact multi-channel multi-electrode systems is attractive because of the simplicity of the procedure and thus its efficiency in the field. However the use of this technique is sometimes discouraged by the bad quality of the measurements in cases of high electrode contact resistances that can render data interpretation infeasible o

Re-injection of groundwater by pressurizing a segmental tunnel lining with permeable backfill

Recently, within a tunneling project, a method for reinjecting discharged groundwater at tunnel level has been investigated. The method was performed by pressurizing a long section of the lining With ungrouted pea gravel as backfill, in a rock mass with low hydraulic conductivity. Water was reinjected through watertight lining into a section where un-grouted pea gravel was used as backfill. The pr

Fermentation of the Straw Material Paja Brava by the Yeast Pichia stipitis in a Simultaneous Saccharification and Fermentation Process

Paja Brava is a native South American grass with a high carbohydrate content. In the current work, the potential of us- ing this feedstock for ethanol production using a simultaneous saccharification and fermentation (SSF) process with the xylose-fermenting yeast Pichia stipitis (Scheffersomyces stipitis) CBS6054 was investigated. The straw material was subjected to SO2 catalyzed steam pretreatmen