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Infiltration of CD163-, PD-L1- and FoxP3-positive cells adversely affects outcome in patients with mantle cell lymphoma independent of established risk factors

We characterised patients with mantle cell lymphoma (MCL) with poor prognosis based on differences in immune infiltration. Different expressions of the tumour cell markers Cyclin D1 and sex-determining region Y-box transcription factor 11 (SOX11), and the immune markers cluster of differentiation 3 (CD3), CD4, CD8, CD25, forkhead box protein P3 (FoxP3), T-box transcription factor TBX21 (T-bet), pr

Aquaculture and the displacement of fisheries captures

In modern aquaculture, animal-production technology is used to increase aquatic food sources. Such controlled rearing of seafood can, in principle, shift the pressure off wild stocks and aquatic ecosys- tems by reducing fishing activities, which may advance marine conservation goals. We examined resource displacement—the reduced consumption of a resource due to its replacement with a more environm

Impact of the COVID-19 pandemic on emergency and elective hip surgeries in Norway

Background and purpose — Many countries implemented strict lockdown policies to control the COVID-19 pandemic during March 2020. The impacts of lockdown policies on joint surgeries are unknown. Therefore, we assessed the effects of COVID-19 pandemic lockdown restrictions on the number of emergency and elective hip joint surgeries, and explored whether these procedures are more/less affected by loc

A novel nonneuronal catecholaminergic system : Exocrine pancreas synthesizes and releases dopamine

Cells of the exocrine pancreas produce digestive enzymes potentially harmful to the intestinal mucosa. Dopamine has been reported to protect against mucosal injury. In looking for the source of dopamine in the small intestine, we found that the duodenal juice contains high levels of dopamine and that the pancreas itself has a high dopamine [and dihydroxyphenylalanine (dopa)] content that does not

Tightly coupled policies and loosely coupled networks in the governing of flood risk mitigation in municipal administrations

Flood risk is a complex and transboundary issue that is expected to escalate with climate change and requires to be governed by collaborative networks of actors. Municipal administrations have been suggested to have a particularly important and challenging role in such governance. Although collaborative governance has attracted intense scientific attention, empirical studies generally focus either

Vacancy-oxygen complex in Ge crystals

Vacancy-oxygen (VO) complexes in Ge crystals have been studied by means of high-resolution infrared absorption and deep-level transient spectroscopy (Laplace DLTS) measurements. It is argued that the VO center in Ge has three charge states: double negative (VO--), single negative (VO-) and neutral (VO0) with the corresponding energy levels at E(- -/-) = E-c-0.21 eV and E(-/0) = E-v + 0.27 eV. Abso

Carrot psyllid (Trioza apicalis) winter habitats - insights in shelter plant preference and migratory capacity

The carrot psyllid (Trioza apicalis) is a serious pest in carrot-growing areas in northern and parts of central Europe. The psyllids overwinter as adults on conifers and during summer feed and lay eggs on carrot plants (Daucus carota ssp. sativus), thereby destroying the crop. To investigate the migratory capabilities and preferences for different shelter plant species of the carrot psyllid, we ma

“Programming is Not That Hard!”. When a Science Center Visit Increases Young Women’s Programming Ability Beliefs

To increase engagement with science and technology, young people around the world are encouraged to attend activities at science centers. But how effective are these activities? Since women have weaker ability beliefs and interest in technology than men, it is especially important to learn how science center visits affect them. In this study, we tested if programming exercises offered to middle sc

The Effects of Yoga on Stress and Psychological Health Among Employees: An 8- and 16-week Intervention Study

Background: The stresses of modern work life necessitate effective copingstrategies that are accessible and affordable to the general public. Yogahas been found to reduce stress in clinical samples, but studies areneeded to examine standard gym yoga classes among functionalindividuals.Objectives: This study investigated the effects of 8- and 16-week gymyoga on stress and psychological health.Desig

Analysis of temperature distribution in potato tissue during blanching and its effect on the absolute residual pectin methylesterase activity

Dynamic changes in absolute residual PME activity in potato tubers undergoing blanching were analysed with regard to the temperature distribution in the tissue after the treatment. The finite-element technique was used to predict the temperature distribution within the tissue during blanching. The temperature-related behaviour of the enzyme indicated that blanching between 60 and 70 degreesC induc

The effect of chain length on the melting temperature and size of dialkyldimethylammonium bromide vesicles

Differential scanning calorimetry (DSc) and dynamic light scattering (DLS) were used to obtain the gel to liquid-crystalline phase transition temperature (T-m) and the apparent hydrodynamic radius (R-h) of spontaneously formed cationic vesicles of dialkyldimethylammonium bromide salts (CnH2n+1)(2)(CH3)(2)N+center dot Br-, with varying chain lengths. The preparation of cationic vesicles from aqueou

Possibilities for sustainable biorefineries based on agricultural residues - A case study of potential straw-based ethanol production in Sweden

This study presents a survey of the most important techno-economic factors for the implementation of biorefineries based on agricultural residues, in the form of straw, and biochemical conversion into ethanol and biogas, together with production of electricity and heat. The paper suggests locations where the necessary conditions can be met in Sweden. The requirements identified are regional availa

Lipase specificity towards eicosapentaenoic acid and docosahexaenoic acid depends on substrate structure.

The fatty acid specificity of five lipases towards eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) was evaluated in the hydrolysis of fish oil, squid oil and a model system. The model system contained methyl esters of EPA, DHA and palmitic acid. All the investigated lipases discriminated against both EPA and DHA more in the model system than in the natural oils. Thus both EPA and DHA we

Introducing the concept of the isodose for optimisation of decontamination activities in a radioactive fallout scenario

In the recovery phase after a radioactive release incident, it is important to be able to focus decontamination operations on the areas that contribute most to the radiation dose. Monte Carlo simulations were applied to determine the shielding effect of a building against radiation from various directions, also giving information on the dose contributions at various locations inside the building f

Molecular recognition and dynamics in proteins studied by NMR

Knowledge of dynamics in protein is very important in the description of protein function and molecular recognition. The thesis investigates protein dynamics on time-scales from milli- to sub-nanosecond, with focus on the latter, using NMR spin relaxation experiments on two proteins, the 138-residue carbohydrate recognition domain of galectin-3 (Gal3C) and the 56-residue B1 domain of bacterial pro

Exploring patient perspectives : A qualitative inquiry into healthcare perceptions, experiences and satisfaction in Lebanon

BACKGROUND: Patient perspectives have received increasing importance within health systems over the past four decades. Measures of patient experience and satisfaction are commonly used. However, these measures do not capture all the information that is available through engaging with patients. An improved understanding of the various types of patient perspectives and the distinctions between them

Swedish or English? : Migrants' experiences of the exchangeability of language resources

Patterns of transmigration emerging as a consequence of globalization are creating new and complex markets for communicative resources in which languages and language varieties are differently valued. In a Swedish context, where lingua franca English can facilitate communication but where monolingual norms prevail and Swedish is positioned as the key to 'integration', the purpose of this study is

Normal and pathological bowel sound patterns.

The purpose of this study was to determine the usefulness of auscultation of bowel sounds in evaluating patients with total and subtotal small intestinal obstruction and immediately after operation. The study was based on ten healthy volunteers, seven patients with documented mechanical obstruction, one patient with chronic subtotal mechanical obstruction and twelve patients undergoing an emergenc