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Inhibition of several of the 10 hallmarks of cancer (Hanahan and Weinberg) would result in a broader and more durable treatment compared to current single or combination drug treatments. Galectin-1 and galectin-3 have been proposed to together be involved in all 10 hallmarks, suggesting that development of a combined galectin-1/3 inhibitor would be beneficial. Specificity toward galectin-1 or -3 c

The purpose of this paper has been to explore how Internet is perceived, with reference to youth, risk and responsibility, by a section of the population in North-West Skåne in Sweden. The questions central to our area of interest were: - Where does the responsibility for a safe Internet environment lie? - What measures are believed to be able to make Internet safer? - Are the opinions about sa

Identification of agricultural pest insects is an important aspect in insect research and agricultural monitoring. We have performed a methodological study of how spectroscopic techniques and wing-beat frequency analysis might provide relevant information. An optical system based on the combination of close-range remote sensing and reflectance spectroscopy was developed to study the optical charac

While numerous antibody-antigen systems have been structurally characterized, studies of structurally analogous T-cell receptor MHC systems have lagged behind largely due to the lack of a general TCR expression system. Efforts to develop bacterial systems have resulted in low yields (< 0.5 mg/l) of active material which is prone to proteolysis and aggregation. Here we report a strategy to secrete

An accident on a passenger ferry may lead to evacuation using lifeboats or liferafts, a process that can be both complex and hazardous. This paper investigates the level of safety for passengers during evacuation based on field study and interview data. In the analysis, the eight goals of Universal Design (UD) were tailored and used to explore what ship and interior characteristics influence evacu

CysK1 and CysK2 are two members of the cysteine/S-sulfocysteine synthase family in Mycobacterium tuberculosis, responsible for the de novo biosynthesis of L-cysteine, which is subsequently used as a building block for mycothiol. This metabolite is the first line defense of this pathogen against reactive oxygen and nitrogen species released by host macrophages after phagocytosis. In a previous medi

The growth of plant-based food and drink substitutes has led to increased interest in oat-based milk substitute as a dairy milk alternative. Conventional liquid oat base (LOB) production results in a fibre-rich insoluble by-product and loss of valuable macronutrients. This study investigates the use of xylanase enzymes to release insoluble arabinoxylan (AX) fibre and employs different degrees of m

Gene therapy using adeno-associated viral (AAV) vectors is a promising approach for the treatment of monogenic disorders. Long-term multi-year transgene expression has been demonstrated in animal models and clinical studies. Nevertheless, uncertainties remain concerning the nature of AAV vector persistence and whether there is a potential for genotoxicity. Here, we describe the mechanisms of AAV v

An experimental study of the influence of an exposed combustible ceiling on compartment fire dynamics has been performed. The fire dynamics in compartments with combustible cross-laminated timber ceilings vs non-combustible reinforced concrete ceilings in otherwise identical compartments with three different ventilation factors were investigated. The experimental results are compared against predi

Four isostructural oxovanadium(V) complexes with hydrazone ligands have been synthesised, characterised, and evaluated as epoxidation and sulfoxidation catalysts. The reactions between [VO(acac)2] (acac– = acetylacetonate) and H2Ln (n = 1–4), precursors for monoanionic tridentate hydrazone ligands, afford complexes formulated as [VO(Ln)(bzh)·MeOH] (1–4) when bidentate benzohydroxamic acid (Hbzh) i

En teknik för att förhindra yterosion och samla ytavrinning är bygga jordvallar (1–1,5 m höga) parallellt medhöjdkurvorna. Denna teknik används över stora områden i Tunisien. I denna studie undersöks hur dessa jord-vallar påverkar ytjordens rumsliga variabilitet av markvattenhalt (θ) och salinitet, dels uttryckt som jordenstotala elektriska konduktivitet (σa) och dels som porvattnets elektriska koOne technique for collecting rainwater and prevent soil erosion applied on large areas in Tunisia involves theuse of soil ridges (1–1.5 m high). These contour ridges are constructed parallel to topographical isolines. Theeffects of the contour ridges on the soil water content (θ) distribution, bulk soil salinity σa, and soil water salin-ity (σw) were investigated in the catchment of El-Gouazine in

“Upper tail knowledge”, embodied by knowledge elites, has been suggested to be a driving force of industrialization and development, yet measuring it remains problematic. Despite some recent innovations, much empirical work continues to rely on measures of “average” or “non-upper tail” human capital such as literacy and years of schooling. We thus turn to perhaps unique sources from Denmark and No

The aim of this study was to analyse sick leave in generalized pustular psoriasis, the most severe form of pustular psoriasis. Prolonged sick leave of >14 days was analysed for 502 patients with generalized pustular psoriasis compared with controls with psoriasis vulgaris and matched controls from the general population. Using data from the Swedish National Patient Register, and the Longitudinal i

The infrastructure for the third generation of mobile telephony, UMTS, is under construction in Sweden. Within three years four operators were to build competing systems to cover 99,98 % of the population. The case of the 3G infrastructure illustrates how sustainability issues are handled in planning and environmental management, with conflicting goals between institutional levels and contradict

Abstract: Sensory impairments in the upper limb are common after stroke. Different sensory modalities can be affected such as sense of touch, pressure, pain, temperature and proprioception. The sensory impairments can negatively affect motor function, dexterity and the ability to perform daily activities. Despite these problems limited attention is paid to sensory impairments in stroke rehabilitat