Filtyp
While numerous antibody-antigen systems have been structurally characterized, studies of structurally analogous T-cell receptor MHC systems have lagged behind largely due to the lack of a general TCR expression system. Efforts to develop bacterial systems have resulted in low yields (< 0.5 mg/l) of active material which is prone to proteolysis and aggregation. Here we report a strategy to secrete
An accident on a passenger ferry may lead to evacuation using lifeboats or liferafts, a process that can be both complex and hazardous. This paper investigates the level of safety for passengers during evacuation based on field study and interview data. In the analysis, the eight goals of Universal Design (UD) were tailored and used to explore what ship and interior characteristics influence evacu
CysK1 and CysK2 are two members of the cysteine/S-sulfocysteine synthase family in Mycobacterium tuberculosis, responsible for the de novo biosynthesis of L-cysteine, which is subsequently used as a building block for mycothiol. This metabolite is the first line defense of this pathogen against reactive oxygen and nitrogen species released by host macrophages after phagocytosis. In a previous medi
The growth of plant-based food and drink substitutes has led to increased interest in oat-based milk substitute as a dairy milk alternative. Conventional liquid oat base (LOB) production results in a fibre-rich insoluble by-product and loss of valuable macronutrients. This study investigates the use of xylanase enzymes to release insoluble arabinoxylan (AX) fibre and employs different degrees of m
Gene therapy using adeno-associated viral (AAV) vectors is a promising approach for the treatment of monogenic disorders. Long-term multi-year transgene expression has been demonstrated in animal models and clinical studies. Nevertheless, uncertainties remain concerning the nature of AAV vector persistence and whether there is a potential for genotoxicity. Here, we describe the mechanisms of AAV v
An experimental study of the influence of an exposed combustible ceiling on compartment fire dynamics has been performed. The fire dynamics in compartments with combustible cross-laminated timber ceilings vs non-combustible reinforced concrete ceilings in otherwise identical compartments with three different ventilation factors were investigated. The experimental results are compared against predi
Four isostructural oxovanadium(V) complexes with hydrazone ligands have been synthesised, characterised, and evaluated as epoxidation and sulfoxidation catalysts. The reactions between [VO(acac)2] (acac– = acetylacetonate) and H2Ln (n = 1–4), precursors for monoanionic tridentate hydrazone ligands, afford complexes formulated as [VO(Ln)(bzh)·MeOH] (1–4) when bidentate benzohydroxamic acid (Hbzh) i
En teknik för att förhindra yterosion och samla ytavrinning är bygga jordvallar (1–1,5 m höga) parallellt medhöjdkurvorna. Denna teknik används över stora områden i Tunisien. I denna studie undersöks hur dessa jord-vallar påverkar ytjordens rumsliga variabilitet av markvattenhalt (θ) och salinitet, dels uttryckt som jordenstotala elektriska konduktivitet (σa) och dels som porvattnets elektriska koOne technique for collecting rainwater and prevent soil erosion applied on large areas in Tunisia involves theuse of soil ridges (1–1.5 m high). These contour ridges are constructed parallel to topographical isolines. Theeffects of the contour ridges on the soil water content (θ) distribution, bulk soil salinity σa, and soil water salin-ity (σw) were investigated in the catchment of El-Gouazine in
“Upper tail knowledge”, embodied by knowledge elites, has been suggested to be a driving force of industrialization and development, yet measuring it remains problematic. Despite some recent innovations, much empirical work continues to rely on measures of “average” or “non-upper tail” human capital such as literacy and years of schooling. We thus turn to perhaps unique sources from Denmark and No
The aim of this study was to analyse sick leave in generalized pustular psoriasis, the most severe form of pustular psoriasis. Prolonged sick leave of >14 days was analysed for 502 patients with generalized pustular psoriasis compared with controls with psoriasis vulgaris and matched controls from the general population. Using data from the Swedish National Patient Register, and the Longitudinal i
The infrastructure for the third generation of mobile telephony, UMTS, is under construction in Sweden. Within three years four operators were to build competing systems to cover 99,98 % of the population. The case of the 3G infrastructure illustrates how sustainability issues are handled in planning and environmental management, with conflicting goals between institutional levels and contradict
This work presents a new approach to the autotuning strategy for controlling pH in raceway reactors, based on classical relay-based autotuning principles. A relay applied to reference method is proposed that allows seamless integration into existing control loops without the need for manual recalibration across seasons or operator intervention. Two different models were identified: first-order wit
Thermal unfolding of whey proteins and whey protein-casein mixtures in simulated milk ultrafiltrate was studied by differential scanning calorimetry. The results are reported as transition enthalpy, temperature of peak maximum, and van’t Hoff enthalpy related to the sharpness of transition. The results of earlier investigations were reviewed. It is suggested that a large part of reported whe
This paper explores the reason why young adults choose to talk about their psychological health and wellbeing on the video-sharing website, YouTube. The study was carried out by six semi-structured interviews with six different ‘YouTubers’ (meaning people who have their own channel and upload videos to the website). To qualify for the study the respondents had to have at least 5000 subscribers to
Syftet med uppsatsen är att, ur ett effektivitets- och brottsutredande perspektiv, undersöka gällande rätt kring gradindelningen av barnpornografibrottet, samt huruvida ökad effektivitet i förundersökningen skulle kunna uppnås om betydelsen av mängden barnpornografi och innehållet i barnpornografin förtydligades. Uppsatsen angår endast barnpornografi genom innehav. I undersökningen har lagtext, dThe purpose of the thesis is, from an efficiency and crime investigation perspective, to investigate the applicable law regarding the classification of child pornography offenses: When is the crime serious and when is it only a minor offence? The focus of the thesis is to investigate the significance of the amount of child pornography, and the significance of the content of the child pornography.
Internal communication is essential in crisis situations. It can build and increase understanding and trust throughout the organization, which in turn can help the organization stand stronger through difficult times. Internal communication professionals play a crucial role to enable understanding, and the need for sensemaking for all organizational actors is proven to increase during crises. Howev
Since the beginning of the 1960’s, there has been a widening gap in GDP per capita between the countries in the regions of East Asia & Pacific and Sub-Saharan Africa. By growing more and shrinking less, some but not all, developing countries have deviated from a state of underdevelopment and caught up with the developed world. Moreover, it has been argued that the biggest chance of catching up
The forest fire that started in the vicinity of Sala in Västmanland 31 July 2014 ended up in being considered to be the biggest forest fire in Sweden for decades. Crisis management as we knew it got a punch on its nose so to speak. Municipalities, fire departments as well as governmental organizations got involved in something they never handled before and maybe for the first time they all had to
The present study investigates the following problem: What are the regulatory structures of land based transportation in the greater Copenhagen area? In order to obtain a comprehensive understanding of this problem, three sub questions were designed to target the structures in detail. These are: How do European regulations on the area of the land based transportation influence the subsidy process
