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Background: As healthcare becomes increasingly complex, new methods are needed to identify weaknesses in the system that could lead to increased risk. Traditionally, the focus for patient safety is to study incident reports and adverse events, but that starting point has been contested with a new era of safety investigations: the analysis of everyday clinical work, and the resilient healthcare. Th
In this study, we investigate the responses of soil organic carbon (C) to nitrogen (N) and phosphorus (P) additions along a soil P stock gradient of five beech forest stands in Germany, using a modelling approach. Two different soil models with coupled C, N, and P cycles are used to simulate fertilization experiments conducted at the study sites. The first model, the stand-alone soil module of QUI
Aims: Real-time perfusion (RTP) adenosine stress echocardiography (ASE) can be used to visually evaluate myocardial ischaemia. The RTP power modulation technique angio-mode (AM), provides images for off-line perfusion quantification using Qontrast (R) software, generating values of peak signal intensity (A), myocardial blood flow velocity (beta) and myocardial blood flow (Ax beta). By comparing re
Background-beta-Adrenergic stimulation is the main trigger for cardiac events in type 1 long-QT syndrome (LQT1). We evaluated a possible association between ion channel response to beta-adrenergic stimulation and clinical response to beta-blocker therapy according to mutation location. Methods and Results-The study sample comprised 860 patients with genetically confirmed mutations in the KCNQ1 cha
Aims: It is well established that the main cause of the development of cardiovascular disease can be found in unhealthy lifestyle habits. In our study, we wanted to explore the long-term predictors of self-reported lifestyle changes in a middle-aged population after screening for cardiovascular risk factors 10 years earlier. Methods: We conducted a 10-year follow-up telephone interview on self-rep
Background: Concern has been raised regarding the mounting collective radiation doses from computed tomography (CT), increasing the risk of radiation-induced cancers in exposed populations. Purpose: To compare radiation dose and image quality in a chest phantom and in patients for the diagnosis of pulmonary embolism (PE) at 100 and 120 peak kilovoltage (kVp) using 16-multichannel detector computed
Background High-resolution genomic microarrays enable simultaneous detection of copy-number aberrations such as the known recurrent aberrations in chronic lymphocytic leukemia [del(11q), del(13q), del(17p) and trisomy 12], and copy-number neutral loss of heterozygosity. Moreover, comparison of genomic profiles from sequential patients' samples allows detection of clonal evolution. Design and Metho
Popular Abstract in Swedish Enbart i Sverige drabbas tusentals personer årligen, kvinnor som män, av plötsligt cirkulationsbortfall (akut ischemi) i ett ben till följd av blodpropp i en artär. Tillståndet är akut och innebär ett direkt hot mot såväl liv som lem. Personer som drabbas är ofta äldre, och de har ofta många andra sjukdomar med sig i bagaget. För att rädda benet, och patienten, krävs aBackground: Acute ischemia of the lower limb is a vascular emergency associated with amputation and death. Patients suffering from acute limb ischemia are usually elderly, and multiple comorbidities are often present. Intra-arterial thrombolysis is, perhaps, the most important minimal-invasive treatment option available today. Although uncontrolled hemorrhage is a dreaded complication, it is consi
Background: Patient-reported outcome (PRO) instruments are used in all medical disciplines to evaluate patients with different diseases and also to follow results after treatments such as surgery. Currently there is no generally accepted and fully validated PRO instrument for the foot and ankle. Aims: To translate the New Zealand Ankle Questionnaire into a Swedish version, [the Self-Reported Foot
We used three animal models of rats for rheumatoid arthritis (RA) in this study. Firstly, We found that CXI induced arthritis (CXIIA) is associated with the RT1 f haplotype and follows a chronic disease course affecting peripheral joints with both progression and relapses. The main difference of pathological changes in CXIIA rats against rats with CIIIA was a larger number of infiltrating lymphocy
Popular Abstract in Swedish Denna avhandling fokuserar en religiös aktör i det civila samhället under en konfliktfylld tid. Judiska, muslimska och kristna barn studerade tillsammans i anglikanska missionsskolor under den brittiska mandattiden i Palestina. Jerusalem var då etniskt och religiöst delat. Det anglikanska utbildningsprojektet var en del av den Anglikanska kyrkans försök att främja konflThis thesis concerns a religious actor in the civil society in times of violent conflict. During the British Mandate period in Palestine, Jewish, Muslim and Christian children studied together at Anglican missionary schools. At this time Jerusalem bore all the imprints of ethnic and religious separation and division. The Anglican educational project became part of the efforts made by the Anglican
Popular Abstract in Swedish Prioriteringar av olika slag har alltid genomförts inom hälso- och sjukvård, vilket har inneburit att vissa verksamheter och patienter har prioriterats och andra har valts bort. Tidigare studier som har varit fokuserade på allmänhetens syn på vem eller vilka som ska prioriteras, har framförallt varit riktade till yngre och medelålders personer. I dessa studier framkommeThe aim of this thesis was to investigate older people's views and experience of prioritisation and resource allocation in health care, which is important because older people are the group that use public health care and service most. The aim was also to investigate differences in the view of prioritisation and resource allocation in relation to age, gender, housing, health-related quality of lif
Background. Bioincompatible glucose degradation products (GDPs) in fluids for peritoneal dialysis (PD) develop during sterilization and storage. Their biological activity has successfully been monitored through the use of various in vitro methods but their molecular and chemical nature is less well understood. Many GDPs are highly reactive carbonyl compounds. Although some of the identified GDPs a
The present study addresses the question why there is a positive relationship between nitrogen deposition and potential net nitrogen mineralisation and nitrification in oak (Quercus robur L.) forest soils in south Sweden (Falkengren-Grerup et al., 1998), and how this is related to the carbon mineralisation. We tested three hypotheses based on European studies (Persson et al., 2000a,b) that postula
The objective of this study was to describe incidence and progression of diabetic retinopathy in relation to medical risk indicators as well as visual acuity outcome after a continuous follow-up period of 10 years in a Type 1 diabetic population treated under routine care. The incidence and progression of retinopathy and their association to HbA(1c), blood pressure, urinary albumin, serum creatini
Popular Abstract in Swedish I många utvecklingsländer i tropiska klimat leder den snabba urbaniseringen till många problem, bl a försämrad termisk komfort i utemiljön. Detta har negativa följder för människors hälsa och välbefinnande och påverkar sociala och kommersiella aktiviteter utomhus negativt. Följaktligen är det mycket viktigt att åstadkomma komfortabla mikroklimat i urban miljö. Den huvuIn many developing tropical countries, rapid urban growth leads to several problems, including increased thermal stress. This has negative consequences for people's health and well-being, and affects social and commercial outdoor activities negatively. Consequently, the creation of thermally comfortable microclimates in urban environments is highly important. The main aim of this thesis is to dee
Previous genome-wide association (GWA) studies have identified SNPs associated with areal bone mineral density (aBMD). However, this measure is influenced by several different skeletal parameters, such as periosteal expansion, cortical bone mineral density (BMDC) cortical thickness, trabecular number, and trabecular thickness, which may be under distinct biological and genetic control. We have car
BACKGROUND: Situational needs of health care facilities inform the optimal allocation of resources and quality improvement efforts. This study examines surgical care delivery metrics at a tertiary care institution in Liberia. METHODS: We retrospectively reviewed operative and ward logbooks from January 1 to December 31, 2012. Data parameters included patients' age, diagnosis, procedure, mortality,
Popular Abstract in Swedish Celler är de minsta levande beståndsdelarna i kroppens vävnader. Under fosterutecklingen och kontinuerligt under livet behöver vävnaderna storlek regleras och gamla celler bytas ut mot nya. Nya celler bildas genom att de gamla delar sig och celler som är skadade, gamla eller inte längre behövs i vävnaden tas bort genom programmerad celldöd. Det innebär att cellerna brytHAMLET (human alpha-lactalbumin made lethal to tumour cells), a protein-lipid complex originally isolated from human milk, induces programmed cell death selectively in tumour cells. It consists of partially unfolded alpha-lactalbumin in complex with oleic acid. It was previously not known if the unfolding of alpha-lactalbumin alone accounts for the activity of HAMLET or if the lipid adds biologica
