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Doxorubicin (DOX) is one of the most widely used anti-neoplastic agents. However, treatment with DOX is associated with cumulative cardiotoxicity inducing progressive cardiomyocyte death. Sirtuin 3 (Sirt3), a mitochondrial deacetylase, regulates the activity of proteins involved in apoptosis, autophagy and metabolism. Our hypothesis is that pharmacological modulation by berberine (BER) pre-conditi

Computer based planning tool for adaptation of living and working environments of physically disabled persons. When adapting living and working environments according to the needs of physically disabled users it is important to optimize design solutions already during the planning process. Therefore it is quite advantageous if the end-user can be involved in the design process to present her or hi

A small release cell, in the form of a rotating disc, has been constructed to fit into the MRI equipment. The present work show that both qualitative and quantitative information of the swelling and erosion behavior of hydrophilic extended release (ER) matrix tablets may be obtained using this release cell and non-invasive magnetic resonance imaging (MRI) studies at different time-points during ma

I den här studien undersöks hur sex gymnasielärare som undervisar i ämnet/kursen Instrument eller sång tänker och resonerar kring deras undervisning i övning. Något som även undersöks är vilka arbetssätt de använder sig av för att främja elevernas självständighet samt vilka övriga faktorer som påverkar övning. Författarnas upplevelser om brister i undervisning kring övning är bakgrunden till ämnetThis study explores six music teachers’ thoughts and reasoning regarding how they teach students to practice. Additional topics examined include what methods teachers use to encourage independence and what other factors affect students’ practice. The study originated from the authors’ perception that the broader teaching community places insufficient emphasis on teaching effective instrument pract

Vad är den äldsta saken vi kan se från jorden? Detta kan verka som udda fråga, men för astronomer är den helt rimlig. Du vet antagligen att ljuset har ändlig hastighet, ungefär 3 * 10^8 m/s. Detta är otroligt snabbt på jorden, men inte lika så i rymden. Alltså, om vi med ljus observerar en galax är antagligen den bild vi ser miljoner, om inte miljarder, år gammal. Detta ger astronomer en sorts &quAstrophysicists have long studied the early Universe in an attempt to explain where galaxies, and by proxy us, come from. In this thesis, the global properties of galaxies at z = 3, where star formation plays a large part , are studied when changing the stellar feedback strength and resolution in simulations. The simulation code used is based on RAMSES, using a similar setup to VINTERGATAN. Four s

Pathogenic isolates of Pyrenochaeta lycopersici, the causal agent of corky root rot of tomato, secrete cell death in tomato 1 (CDiT1), a homodimeric protein of 35 kDa inducing cell death after infiltration into the leaf apoplast of tomato. CDiT1 was purified by fast protein liquid chromatography, characterized by mass spectrometry and cDNA cloning. Its activity was confirmed after infiltration of

Recent years have witnessed an explosion of interest in understanding the role of conformational dynamics both in the evolution of new enzymatic activities from existing enzymes and in facilitating the emergence of enzymatic activity de novo on scaffolds that were previously non-catalytic. There are also an increasing number of examples in the literature of targeted engineering of conformational d

Genetic analyses were conducted on tumor samples from 88 patients with uveal melanoma (UM), 6 of whom carry pathogenic germline variants in BAP1. We assessed the frequency, pattern, and prognostic significance of somatic aberrations, and investigated differences between germline BAP1 variant carriers compared to sporadic cases. The frequency of the main oncogenic driver mutations was not significa

Antimicrobial resistance is one of the largest threats to global health. In society as well as in healthcare facilities, antimicrobial resistance is rapidly increasing with the main reason being overuse and misuse of antibiotics combined with inadequate infection prevention. For humans, dental care accounts for about 10% of all antibiotic prescriptions, making it an important target for antibiotic

The traditional Talmian binary typology of satellite-framed vs. verb-framed languages has proven to be insufficient for showing the diversity across the world’s languages. One approach within post-Talmian motion typology follows Holistic Spatial Semantics, which has been applied to languages like Swedish, French, Thai and Telugu, but not to Slavic languages. This motivates the present research. We

Our understanding of public support for climate policies predominantly stems from studies in the Global North and a focus on isolated policy types. Here, we examine how public support for four different climate policy types and the effect of ideological explanatory variables on such support vary among countries of the Global North and Global South. We surveyed representative samples of each three

The inherently weak chiroptical responses of natural materials limit their usage for controlling and enhancing chiral light-matter interactions. Recently, several nanostructures with subwavelength scale dimensions were demonstrated, mainly due to the advent of nanofabrication technologies, as a potential alternative to efficiently enhance chirality. However, the intrinsic lossy nature of metals an

Despite the affluence of modern societies, socioeconomic gradients in health and lifespan are widespread across the developed world. A mortality gradient by socioeconomic status (SES) is evident even in the most egalitarian welfare societies, where basic needs like food, safe housing, and health care are universally provided. However, it remains unclear whether such a gradient also existed in hist

In 2016, the European Hematology Association (EHA) published the EHA Roadmap for European Hematology Research1 iming to highlight achievements in the diagnostics and treatment of blood disorders and to better inform European policy makers and other stakeholders about the urgent clinical and scientific needs and priorities in the field of hematology. Each section was coordinated by 1 to 2 section e

We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 ×

The work environment and especially the psychosocial work environment influence the mental and physical well-being of employees. The aim of this study was to identify and analyse the state of knowledge regarding nurses’ work situation, health, and person-centred work during the COVID-19 pandemic through a systematic review. Methods: Systematic Review, nine included articles. The theoretical swAge

The guided gliding of cytoskeletal filaments, driven by biomolecular motors on nano/microstructured chips, enables novel applications in biosensing and biocomputation. However, expensive and time-consuming chip production hampers the developments. It is therefore important to establish protocols to regenerate the chips, preferably without the need to dismantle the assembled microfluidic devices wh

We compared hippocampal subfield and entorhinal cortex (ERC) volumes between patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and controls without cognitive impairment. Additionally, we investigated the relation between age and hippocampal subfields and ERC in controls. We performed ultra-high field 0.7 mm(3) 7Tesla magnetic resonance imaging in 16 patients with amnestic MC