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Protein environment and structure in neat and hydrated deep eutectic solvents

Detta är ett arbete som som syftar till att studera hur djupa eutektiska lösningsmedel påverkar proteinerna bovin serumalbumin och lysozym Ett djupt eutektiskt lösningsmedel är ett lösningsmedel som skapas när två eller fler fasta material, mer specifikt en vätebindningsacceptor (ofta ett kvartärt ammoniumsalt) och en vätebindningsdonator, bildar ett omfattande vätebindningsnätverk. Detta genererThe use of deep eutectic solvents (DESs) has a great potential in the pharmaceutical field due to its many advantages such as biocompatibility, low toxicity and biodegradability. Studies have also shown that proteins can be successfully incorporated into DESs. However, protein stability and structure in these solvents need to be investigated for this technology to be applicable. When adding the pr

A new correlation between diluent fraction and laminar burning velocities : Example of CH4, NH3, and CH4 + NH3 flames diluted by N2

Modern combustion processes widely use exhaust gas recirculation, oxyfuel combustion, and other techniques that alter the concentration of diluent gases from that of the air. The dilution's impact on the laminar burning velocity, SL, is therefore a crucial effect that has been studied experimentally and numerically in the literature. However, an accurate fitting correlation with physical meanings

Nutrient dynamics, microbial growth and weed emergence in biochar amended soil are influenced by time since application and reapplication rate

Evidence suggests that in addition to sequestering carbon (C), biochar amendment can increase crop yields, improve soil quality and nutrient cycling, reduce the leaching of nutrients from soil and stimulate soil microbial activity. However, biochar application primarily benefits soils of intrinsic poor quality, thus the advantages of adding biochar to temperate agricultural soils remains controver

Patient safety and predictors for subsequent healthcare contact after self-care referral from Swedish ambulance services: a retrospective cohort study

BackgroundAmbulance clinicians increasingly refer patients to self-care, positioning ambulance service within a wider gatekeeping role and necessitating the assessment of whether self-care is a safe option or if further support is needed. Contrary to primary healthcare centre (PHC) referrals, self-care referrals often lack structured follow-ups, with the decision consequences remaining underexplor

Associations between the C-reactive protein-triglyceride glucose index and the incidence and progression trajectory of cardiometabolic multimorbidity : a multi-state model study

Background: The C-reactive protein-triglyceride-glucose index (CTI) has been proposed as a novel biomarker for insulin resistance and inflammation. However, its role in the progression trajectory of cardiometabolic multimorbidity (CMM) remains unclear. We aimed to investigate the involvement of the CTI in the CMM progression trajectory. Methods: This prospective study included 266,049 individuals

Studies towards ß-turn mimetics, synthesis of kedarosamine from threonine, and synthesis of glycopeptides from mucins and gp120

The secondary structure of proteins is crucial for proper function of the protein in biological systems. Peptide T, an octapeptide from the envelope glycoprotein gp120 of the HIV virus, has previously been shown to be responsible for binding to the CD4 receptor on T helper/inducer lymphocytes. NMR studies showed that the four C-terminal amino acid residues of peptide T adopted a beta-turn conforma

Memory Distortions Induced by Fluency : Behavioural and Electrophysiological Investigations

Popular Abstract in Swedish Att gifta sig eller att vara med om en olycka är emotionella händelser som skapar våra mest livfulla och detaljerade minnen. Sådana minnen av händelser i tid och rum kallas generellt episodiska minnen. De flesta människor minns till exempel nästan exakt var de var när de hörde talas om terrorattackerna i New York 2001. De flesta av oss har nog redan glömt vad som hände The investigation of memory distortions provides insights into how memory normally works. Adopting a cognitive neuroscience perspective, the present thesis aimed at investigating memory distortions and the neural correlates of processes contributing to successful control of memory interference in healthy participants. All studies employed variations of the modified continuous recognition task. In

Temperature effects on UV-B induced DNA damage and repair in plants and a lichen

Popular Abstract in Swedish Alla levande organismer har DNA, och eftersom DNA är livsnödvändigt måste det repareras om det blir skadat. Ultraviolett (UV) strålning från solen är en av de vanligaste orsakerna till att DNA skadas. De flesta skador på DNA som orsakas av UV-strålning utgörs av cyklobutan-pyrimidindimerer (CPD) eller (6-4)-fotoprodukter. Dessa skador består av två intilliggande baser sAll living organisms have DNA and since DNA is essential to life it must be repaired when damaged. UV radiation is one of the major DNA damaging agents, which photosynthetic organisms cannot avoid. The major UV-induced DNA lesions are cyclobutane pyrimidine dimers (CPDs) and (6-4) photoproducts (6-4PPs) and the main repair pathways of theses lesions involve photolyases and various excision repair

En modell för dimensionering av förbindelser för utrymning utifrån funktionsbaserade krav

This report describes a model for the estimation of the time required to evacuate a building, by dividing the evacuation process into three phases: awareness, behaviour and response, and movement. The times required in each of these phases can be estimated separately and the sum then represents the total evacuation time. The time elapsed from the fire breaking out, to the discovery of the fire, is

Slutrapport: projektet “Citeringsmönster i Open Access-tidskrifter” inom ramen för programmet OpenAccess.se

Introduction. Along with the great expansion of research being published in Open Access (OA) journals over the last decade, the interest for analysing the OA literature using informetric methods has also increased. Most studies have focused on the citation impact of OA journals and whether OA publishing increases the chances of a research publication being cited. Fewer analyses, however, have inve

Non-adrenergic, non-cholinergic neural activation in guinea-pig bronchi: powerful and frequency-dependent stabilizing effect on tone

1 We examined non-adrenergic, non-cholinergic (NANC) stimulation for its stabilizing effect on bronchial smooth-muscle tone with respect to its regulatory power and the effect of variations in neural impulse frequency. 2 The guinea-pig isolated main bronchus (n = 4-12) was pretreated with indomethacin (1O JAM) and incubated with atropine (1 pM) and guanethidine (10 JM). Electrical field stimulatio

Skolpolitik, skolutvecklingsarena och sociala processer : Studie av en gymnasieskola i kris

Popular Abstract in Swedish Föreliggande avhandling är en fallstudie vars empiriska material utgörs av kvalitativa forskningsintervjuer, deltagande observationer och textdokument. Avhandlingen uppmärksammar ett händelseförlopp på en nystartad svensk gymnasieskola. Förloppet inleds med kommunens och rektorns stora visioner för verksamheten och avslutas med att en samstämmig lärargrupp avsätter rektThis dissertation is based on a case study of a series of events at a newly started Swedish high school. The study employs a qualitative methodology comprising of interviews, participant observation and analysis of text documents. The series of events opens with the grand visions of the municipality and the school's principal for the school and concludes with the teachers at the school unanimously

Ett paradis för alla. Epa mellan folkhem och förförelse

Popular Abstract in Swedish ETT PARADIS FÖR ALLA. EPA MELLAN FOLKHEM OCH FÖRFÖRELSE I början av 1930-talet etablerades en ny form av konsumtion i Sverige när Enhetsprisaktibolaget Epa öppnade dörrarna för en hänförd och överväldigad allmänhet. Hörnstenar i Epa-systemet var fasta priser, massproducerade produkter, stora lagerutrymmen och låga leveranskostnader. Varorna var avsedda för en ny bred kA Paradise for All. Epa between the People's Home and Seduction. This dissertation is about the Epa department store chain, which existed in Sweden from 1930 to 1977. For many people, Epa was an arena for meeting modernity. By allowing issues of tradition and modernity, cultural learning processes, class, gender and aesthetics to collide with the Epa phenomenon, a complex picture of the Swedish P

Genetic Profiling in Soft Tissue Sarcoma

Soft tissue sarcomas (STS) are a heterogeneous group of highly malignant mesenchymal tumors that account for ~1% of all malignancies. Frequent heterogeneity and pleomorphism along with suboptimal diagnostic reproducibility and insufficient prognostic markers make clinical management of these tumors difficult. This thesis has applied microarray-based gene expression and copy-number profiling to STS

Mammalian Molecular Systematics with Emphasis on the Insectivore Order Lipotyphla

Insectivore classification has been one of the most controversial problems in mammalian systematics. Evolutionary relationships among the six extant families, Talpidae (moles), Soricidae (shrews), Erinaceidae (hedgehogs), Tenrecidae (tenrecs), Chryosochloridae (golden moles), and Solenodontidae (solenodons), have remained uncertain based on morphological data. Animals classified within the order L

Cluster-Based Catalysts for Asymmetric Synthesis.

Popular Abstract in Swedish Asymmetrisk syntes för framställning av optiskt rena substanser är av stort intresse, inte bara för forskningsändamål utan även för praktiska tillämpningar inom flera olika branscher. Dagligen stöter man på produkter som har sitt ursprung i asymmetrisk syntes; allt från dofter, smakämnen och livräddande läkemedel till nya praktiska plaster med skräddarsydda egenskaper. In this work, the synthesis and characterisation of new low-valence transition metal carbonyl clusters, and an investigation into their viability to act as catalysts/catalyst precursors in asymmetric synthesis, are described. Carbonyl clusters based on ruthenium and osmium have been tested as (pre)catalysts for asymmetric hydrogenation of alpha-unsaturated carboxylic acids, and cobalt carbonyl clu

Improving Procurement Performance with E-business Mechanisms

E-procurement — e-business mechanisms deployed on procurement — offers many recent and innovative methods that can improve procurement in different ways. The key challenge of e-procurement, however, is how to apply the various e-procurement applications in such a way that they improve the procurement practice and sourcing strategy of a company. There is a demand for an investigation that scrutiniz

Floodwater harvesting for artificial recharge of groundwater - estimation and prediction for arid Iran

Popular Abstract in Swedish Regnvatteninsamling genom översvämningskontroll för artificiell grundvatteninjektering är en traditionellt använd metod i arida och semiarida Iran. Metoden har använts under flera tusen år för att öka andelen vatten som kan användas till jordbruksproduktion. Under de senaste 100 åren har emellertid mycket av den traditionella kunskapen om dessa metoder fallit i glömska Groundwater depletion in arid and semiarid areas is of increasing concern. Increasing water demand due to increasing population and climate change impacts have intensified the water shortage problems and put further stress especially on groundwater. Water harvesting techniques have been traditional solutions to water scarcity problems in the arid and semiarid Middle East for thousands of years. Th

Meningserbjudanden och val: En studie om musicerande i musikundervisning på högstadiet

The purpose of this study is to elucidate affordances and meaning-making processes where students in Compulsory lower secondary education learn to play music together in music class. The data consists of a series of observed music lessons, performances and stimulated recall interviews in two 8th form classes, video recorded in the course of one term. The analysis focuses on students’ and their tea