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Germline mutations in the CDKN2A tumor suppressor gene located on 9p21 have been linked to development of melanomas in some families. A germline 3-bp insertion in exon 2 of CDKN2A, leading to an extra arginine at codon 113 (113insR), has been identified in 17 Swedish melanoma families. Analysis of 10 microsatellite markers, spanning approximately 1 Mbp in the 9p21 region, showed that all families
Estramustine (EM), a complex between estradiol-17 beta and nornitrogen mustard, is commonly used in the treatment of prostatic cancer. The exact mechanism of action is unknown but has previously been considered to be mediated through non-DNA targets, specifically with the mitotic spindle, and to be related to the intact EM complex. In the present study, using different cell-systems (monocyte phago
In 1996, two searchable databases covering insect pathogens were posted on the World Wide Web: the Ecological Database of the World's Insect Pathogens (EDWIP) and the Viral Diseases of Insects in the Literature database (VIDIL). In this paper, we describe the format and contents of EDWIP and VIDIL on the World Wide Web. EDWIP contains over 9400 pathogen-host association records, 677 negative test
When semi-natural pastures are abandoned, specialized grassland species are lost as a consequence of succession. As a counter-measure, previously abandoned grasslands may be restored by clearing shrubs and trees and re-introducing grazing livestock. In order to examine the effects of this type of habitat restoration, we compared species richness of plants and of specialized plants thought to be de
Rotational Raman linewidths calculated from three different models have been used in temperature measurements by rotational coherent anti-Stokes Raman scattering (CARS)—a semiclassical ab initio model, the modified exponential energy gap model (MEG), and the energy corrected sudden scaling law (ECS). Experimental rotational CARS spectra were generated, using the dual-broadband approach, in pure ni
Organisms present a series of cellular mechanisms to avoid the effects of toxic compounds. Such mechanisms include the increase in activity of detoxification enzymes [e.g., 7-ethoxyresorufin-O-deethylase (EROD) and glutathione S-transferase (GST)I, which could explain the low retention of ingested toxins generally observed in copepods. In addition, decreasing gross growth efficiency (GGE) of copep
The purpose of the present study was (1) to investigate the association between insomnia and alexithymia, as measured by the Toronto Alexithymia Scale (TAS-20) and its subscales, and (2) to test if the TAS20 and its subscales show the same correlational pattern with anxiety, depression and perfectionism in insomnia patients as has previously been found in non-clinical samples. A consecutive series
Background: Midgut carcinoid tumours often present with widespread disease making curative surgery impossible. Medical treatment therefore plays a major role in the treatment of these patients. Methods: In this prospective randomized study, the effect of interferon (IFN) alpha on survival and risk of tumour progression was evaluated in 68 patients with midgut carcinoid tumours metastatic to the li
A small release cell, in the form of a rotating disc, has been constructed to fit into the MRI equipment. The present work show that both qualitative and quantitative information of the swelling and erosion behavior of hydrophilic extended release (ER) matrix tablets may be obtained using this release cell and non-invasive magnetic resonance imaging (MRI) studies at different time-points during ma
Postural adaptability and responses elicited by vibratory stimulation to the calf muscles recorded on a force platform with eyes open or closed were analyzed in 39 patients suffering from Postural Phobic Vertigo (PPV) (17 men and 22 women, mean age 49 years) and 24 healthy subjects (14 men, 10 women, mean age 38 years). The vibration induced increased body sway in both groups, but the adaptation p
Future anthropogenic climate change is likely to increase the air temperature (T a ) across Europe and increase the frequency, duration and magnitude of severe heat stress events. Heat stress events are generally associated with clear-sky conditions and high T a , which give rise to high radiant heat load, i.e. mean radiant temperature (T mrt ). In urban environments, T mrt is strongly influenced
The successful planning, design and management of a traffic system is impossible without knowledge of how the traffic environment affects the behaviour of road users and how the behaviour is related to the main qualities of the traffic system (e.g. safety, efficiency). Automated video analysis is a promising tool for traffic behaviour research in that it enables collection of micro-level behaviour
Benchmarking is an effective tool to compare the performance of full-scale wastewater treatment plant operation. In this study, 29 wastewater treatment plants from eight countries were surveyed with the aim of developing some key performance indicators, which may be used for benchmarking purposes. The level of utilisation of instrumentation, control and automation (ICA) has also been measured. The
This study was aimed to optimize glucose level at different stages of buffalo in vitro embryo production procedure. Three glucose levels (1.5, 5.6 and 10 mm) along with a control (0 mm) were used at three phases of in vitro fertilisation (IVF) procedure viz. in vitro maturation (IVM), in vitro culture (IVC-I) (12-72 hpi) and IVC-II (72 hpi to 7 dpi). Maturation rate of oocytes was found different
The mutation status of the immunoglobulin heavy chain variable regions (IgVH) has been found to be a good prognostic indicator for B-cell chronic lymphocytic leukemia (CLL) because unmutated VH genes are associated with rapid disease progression and shorter survival time. To study the differences in gene expression between the Ig-unmutated and Ig-mutated CLL subtypes, we performed gene expression
Virtual Reality (VR) has shown great potential in various training applications. In the field of cognitive rehabilitation it has been shown that VR technology can become a useful complement to conventional rehabilitation techniques (e.g. Rizzo et al. (2002), Brown et al. (2002) and Kizony et al. (2002)). An important part of a brain injury patient’s rehabilitation process is practicing instrumenta
The starting point in this thesis is stroke inflicted individuals’ stories about their experience of stroke, relations in everyday life, and their relations and attempts to return to paid work with the objective of gaining a further understanding of what happens when inflicted by illness and/or disability in working age. Furthermore, it aims at understanding how social relations and ruling relatio
The RWAAI (Repository and Workspace for Austroasiatic Intangible heritage) project aims at building a digital archive out of existing legacy data from the austroasiatic language family. One aspect of the project is the preservation of analogue legacy data. In this context, we have at our hands a large number of mostly-phonemic transcriptions of narrative monologues, often with accompanying sound r
The subjects of this article are Kozhevnikov and Chistovitch's finding regarding the constancy of relative syllable durations and the inconstancy of relative speech sound durations for different rates of speech, and their proposal that vowels are elided because the necessary minimum duration of a consonant consumes all the time that happens to have been assigned to the syllable. The relative cons
Up until the late nineteenth and early twentieth century, and probably since the introduction of agriculture to Sweden, the social life, culture, traditions, building patterns and material culture would largely have been based on agricultural practices. And yet, in the archaeological record, agricultural aspects of social life remain elusive and little is known about the organization of farming an
