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The purpose of this study is to identify and structure challenges of measuring performance of the Sales and Operations Planning (S&OP) process. A multiple case study methodology was applied. Qualitative data was collected via 22 structured interviews with managers from six case companies in various industries. A process oriented framework was proposed by structuring the challenges based on two
Axons show a poor regenerative capacity following traumatic central nervous system (CNS) injury, partly due to the expression of inhibitors of axonal outgrowth, of which Nogo-A is considered the most important. We evaluated the acute expression of Nogo-A, the Nogo-66 receptor (NgR) and the novel small proline-rich repeat protein 1A (SPRR1A, previously undetected in brain), following experimental l
Background More than half of cardiovascular mortality occurs outside the hospital, mainly due to consistently low survival rates from out-of-hospital cardiac arrest. Methods This is a prospective, nested, case-control study derived from the Västerbotten Intervention Programme and the World Health Organization's Multinational Monitoring of Trends and Determinants in Cardiovascular Disease study in
OBJECTIVE: Although the underlying cause of Huntington's disease (HD) is well established, the actual pathophysiological processes involved remain to be fully elucidated. In other proteinopathies such as Alzheimer's and Parkinson's diseases, there is evidence for impairments of the cerebral vasculature as well as the blood-brain barrier (BBB), which have been suggested to contribute to their patho
Background & purpose Infants on chronic peritoneal dialysis (PD) have an increased risk of developing neurological morbidities; however, the underlying biological mechanisms are poorly understood. In this clinical study, we investigated whether PD-mediated impairment of nitric oxide (NO) bioavailability and signaling, in patients with persistently low systolic blood pressure (SBP), can explain
Protein kinase C iota (PKCι), a serine/threonine kinase required for cell polarity, proliferation and migration, is commonly up- or downregulated in cancer. PKCι is a human oncogene but whether this is related to its role in cell polarity and what repertoire of oncogenes acts in concert with PKCι is not known. We developed a panel of candidate oncogene expressing Madin-Darby canine kidney (MDCK) c
Use of a highly sensitive, selective capacitive biosensor is reported for label-free, real-time, easy and rapid detection of trypsin by using the microcontact imprinting method. Real-time trypsin detection was performed with trypsin-imprinted (trypsin-MIP) capacitive electrodes using standard trypsin solutions in the concentration range of 1.0×10−13–1.0×10−7 M with a detection limit of 3.0×10−13 M
The signal crayfish (Pacifastacus leniusculus) was introduced to Sweden in 1960, and it has a high commercial and recreational value, but it may also have negative effects on native ecosystems. To better predict how climate warming will affect population dynamics of this cool-water crayfish, we explored the role of temperature and density dependence as explanatory factors of the subsequent years’
A research-based understanding of permafrost distribution at a sufficient spatial resolution is important to meet the demands of science, education and society. We present a new permafrost map for Norway, Sweden and Finland that provides a more detailed and updated description of permafrost distribution in this area than previously available. We implemented the CryoGRID1 model at 1km2 resolution,
This thesis aims to reveal the role and significance of occupational clothing for the wearers, exposing some of the thoughts, ideas and opinions that pharmacy workers have about their work uniform, the white coat. My own experiences from working in an environment (a pharmacy) where occupational uniforms were used was one of the reasons for selecting this thesis topic. My interest was also consolid
This study examines and compares theoretical CDS spreads created by a structural framework with empirical CDS spreads. The model employed is the CreditGrades model based on the Merton framework from 1974 which calculate default probabilities and credit spreads from balance sheet and equity data. The aim is to measure how well the model can explain the observed CDS spreads and if it has any predict
Artificial insemination using the husband's sperm (AIH) and artificial insemination using sperm from a donor (AID) are artificial techniques which have been used for a long time, however, other forms of artificial procreation such as, in vitro fertilization (IVF), egg donation, embryo donation, and surrogacy are seen as truly modern reproductive techniques and did not come into use until the m
This thesis analyses the debate around the patents on human genes from three most important angles: ethical, legal and economic. In the ethical context, patents on gene-related inventions are often seen as inappropriate because of the alleged special status of human DNA. The special status stems from their alleged responsibility for everything from diseases to social propensities and personal trai
The cultural board of region Skåne decided fall of 2008 to reorganize the fundings of the cultural pedagogy. What the reorganization implicates is that the everyday practice of the pedagogues will not be paid for by the region, and instead the pedagogues will focus on capacity building and competence maintaining towards all of those who work pedagogically with children. They will work in five diff
“I’m different all the time” – A qualitative study of young people’s roles and collective identity formation in different parts of Gothenburg The purpose of this study was to compare young people’s view of their neighborhoods, and what significance the residential area has for their collective identity formation. Young people living in a residential area with a low proportion of native Swedes, lo
All companies face risk in their daily business. Internationalised companies tend to experience higher risk due to for example unfamiliar business environment than companies that act only on the national market. Estonia became independent as late as in 1991 and is therefore a new interesting market for many companies in neighbouring countries like Sweden. Risks that are most apparent for an intern
Power production represents one fourth to one third of all CO2 emissions. Carbon Capture and Storage (CCS) in one way to approach the increasing problem with CO2 emissions from fossil fuelled power plants. The CO2 is separated, compressed and transported to a final storing site. To allow more efficient transport and to match the pressure of the final storing site, the CO2 is compressed to a superc
To allow the user interface in a mobile phone more space, slide modules are implemented. The usage of slide modules introduces many new challenges when designing a mobile phone. New solutions to these challenges is the main scope for this thesis. Nokia currently has several different slide phones out on the market implementing some sort of slide module. The slide module provides extra space for th
Problem: The industry structure could be viewed as changing. A problem for some mangers is the knowing how the consequences of their decisions affect their supply chain in advance. Purpose: The purpose is divided into two parts. (1) To examine the possibility of applying the complexity theory through an agent-based model at a supply chain. (2) To investigate and evaluate different future scenarios
The turn of the twentieth century was a period of rapid decline in infant- and child mortality and a time of industrialization and urbanization in Sweden. It was also a period of growing social disparities in childhood mortality. The inequality in child survival was connected to a range of factors, including access to water- and sanitation, housing conditions, infant care, and possibly nutrition.
