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Background: Glomerular filtration rate (GFR) is a key indicator of kidney function, typically estimated using creatinine or cystatin C. When cystatin-C-based eGFR is markedly lower than creatinine-based eGFR, this discrepancy may reflect a selective impairment in the filtration of medium-sized molecules, referred to as Shrunken Pore Syndrome (SPS), or more broadly, Selective Glomerular Hypofiltrat
This study analyzed daily temperature data from 114 meteorological stations in the Qinling-Daba Mountains from 1980 to 2017, focusing on core zones (CE I ≥ 2274 m, CE II 1321–2274 m) and peripheral zones (PE I 668–1321 m, PE II < 668 m). Using 15 extreme temperature indices computed with RClimDex, we assessed the spatiotemporal patterns, trends, and response to climate warming of extreme temperatu
Stroke and anemia are both prevalent conditions with significant health burdens, yet their bidirectional relationship remains poorly understood. Anemia affects up to 29 % of stroke patients and is associated with increased worse outcomes. However, the causal nature of this association, particularly concerning different anemia subtypes, remains controversial, and there is a lack of clear targets an
BACKGROUND AND OBJECTIVE: Prostate cancer (PC) and dementia may commonly co-occur; yet, prior evidence for bidirectional associations is inconsistent. This study aims to determine the associations between PC and dementia in large population-based studies, which may further inform clinical care. METHODS: To assess the dementia risk in men with PC, a national cohort study was conducted in 178 746 me
Bakgrund: I flera havsnära kommuner finns attraktiv mark med vattennära och central lokalisering som utnyttjas ineffektivt. Hur kan man ta tillvara på denna mark och hur har tidigare exploateringar genomförts? Utgångspunkten för studien var att hitta en bättre användning för mark i hamnområden vilket födde exjobbsidén. Svårigheter i exploateringsprojekt inom hamnområden har tidigare varit förknippBackground: In several seaside municipalities, there are attractive pieces of land with central location, near the water, that are inefficiently used. How is the land utilized and how has previous exploitation projects been carried out? The starting point for the study was to find a better use for ground areas in harbours, which gave birth to the idea for this master thesis. Difficulties in earlie
Statistical analysis of long-term morphological data on coastal sedimentary features provides important information on the processes governing these features and their evolution in space and time. In this paper, seasonal, yearly and decadal (i.e. long-term) behavior of coastal morphological features is derived from field data by using both simple and advanced statistical techniques. The sedimentar
This thesis deals with motion in language and non-linguistic experience, distinguishing between actual motion (AM) and non-actual motion (NAM). AM is the experience of continuous change in an object’s position, expressed in sentences such as 'The man runs through the forest' and 'The woman is walking'. NAM refers to dynamic qualities involved in conceiving or perceiving static situations and is ex
Organic farming may contribute substantially to future agricultural production worldwide by improving soil quality and pest control, thereby reducing environmental impacts of conventional farming. We investigated in a comprehensive way soil chemical, as well as below and aboveground biological parameters of two organic and two conventional wheat farming systems that primarily differed in fertiliza
Objective – To identify key factors affecting the probability of obtaining an interview and being hired for an academic library position. Design – An online survey was distributed via the following electronic mail lists: ACRL, LITA, COLLIB, METRO, ACQNET, COLLDV, ULS, EQUILIBR, and ALF. The questionnaire was posted via StudentVoice, an assessment survey provider. Setting – Academic libraries in
Background: The benefits of exercise in mild and moderate knee or hip osteoarthritis (OA) are apparent, but the evidence in severe OA is less clear. We recently reported that neuromuscular training was well tolerated and feasible in patients with severe primary hip or knee OA. The aims of this controlled before-and-after study were to compare baseline status to an age-matched population-based refe
Popular Abstract in Swedish Energianvändningen i världen måste minska drastiskt inom en snar framtid för att därmed minska utsläppen av växthusgaser och bromsa klimatförändringarna. Energi och handlande med energikällor har även blivit nationella säkerhetsfrågor. Inom Europeiska Unionen används ungefär 40% av den totala energianvändningen i byggnader, vilket innebär ungefär 36% av det totala koldiThe use of energy is a major global issue both according to climate changes but also in the aspect of national safety tied to the trade with energy sources. Of the total energy use in the member states of the European Union, about 40% is used in residential and commercial buildings. Passive houses are one way to reduce the energy use in buildings and at the same time keep a good indoor comfort. Th
Popular Abstract in Swedish Cystisk fibros (CF) är en ärftlig sjukdom som orsakas av en defekt jonkanal. Denna defekt ger upphov till en onormal saltbalans i kroppen och följderna blir många. I lungorna och magtarmkanalen produceras ett väldigt segt slem vilket täpper till luftvägarna och medför andningssvårigheter. De slemfyllda lungorna klarar inte av att transportera upp slemmet och istället stCystic fibrosis is an inherited disease, caused by mutations of the cystic fibrosis transmembrane conductance regulator gene. The gene codes for a protein that serve as chloride channel. In cystic fibrosis, this protein is lacking or has a defect function resulting in a thick and sticky mucus of the airways. The altered airway environment promotes mucus and growth of pathogenic bacteria. A common
The indigenista novel is a realistic novel with a strongly ideological character that was developed primarily in the Andean countries (Peru, Bolivia, Ecuador) during the first half of the 20th century with the purpose of making the reader aware of the living conditions of the indigenous Native American population. The overall aim of this study was to investigate the female characters in five of th
Colorectal cancers are globally ranked as the third most common cancer form in terms of incidence and mortality. Diet has long been considered as one of the main factors affecting population outcome regarding development of cancer in the colon. Numerous epidemiological studies have found links between consumption of dietary fibres and milk and reduced risk of cancers including colon cancer. To be
Background Rye products have been demonstrated to lower the acute insulin demand, induce a low and prolonged blood glucose response (high Glycemic Profile, GP) and reduce subclinical inflammation. These products may therefore contribute to a lowered risk of obesity, type 2 diabetes and cardio vascular disease. The objective of the present paper was to evaluate the mechanism for a reduced postprand
Although no common genetic defect has been described in chronic lymphocytic leukemia (CLL), recurrent genomic aberrations (i.e. deletions of chromosome 11q, 13q, 17p and trisomy 12) are important for prognostication. Deletion of 13q as single aberration is associated with the best prognosis, whereas del(11q) and del(17p) predict a poor outcome. Recent development of high-resolution genomic techniq
Popular Abstract in Swedish Immunsystemet är ett invecklat och komplext system som finns överallt i kroppen och som inte är begränsat till ett enda organ. Vi utsätts hela tiden för ”angrepp” från mikro-organismer (t.ex. bakterier eller virus) men också för främmande ämnen som kan vara skadliga eller giftiga. Immunsystemets huvudfunktion är att hjälpa kroppen att känna igen dessa ”angripare” och atThe overall aim of this PhD project was to gain insight into the incidence of primary immunodeficiency (PID) in southern Sweden and to optimize diagnostic and treatment measures for these patients. We estimated the occurrence rate of PID in the pediatric population of southern Sweden during a period of 4 years and described the demographic, clinical and immunological characteristics of the identif
Background: Rye products have previously been shown to induce comparatively low post-prandial insulin responses; irrespectively of their glycaemic indices (GI). However, the mechanism behind this lowered insulin demand remains unknown. An improved insulin economy might contribute to the benefits seen in epidemiological studies with whole grain diets on metabolic risk factors and weight regulation.
Biodiversity, the variety of life at all organisational levels from genes to ecosystems, affects ecosystem processes and therefore the goods and services ecosystems provide. More research is needed to provide new insights into biodiversity changes and the processes that drive these changes, in order to formulate effective policy and conservation measures to stop the ongoing biodiversity loss. In t
This thesis is based on four projects with the overall aim to investigate vitamin K-dependent protein S functions in relation to its structure. The anticoagulant functions of protein S can be divided in three: 1) cofactor for activated protein C (APC), 2) cofactor for tissue factor pathway inhibitor (TFPI) and 3) APC and TFPI-independent anticoagulant functions. Microparticles might be shed from
