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The main purpose of this master thesis was to test a novel approach of finding leads for new pharmaceuticals, by using Solid Phase Peptide Synthesis (SPPS) in combination with Weak Affinity Chromatography (WAC). Put in a more concrete way, the objective was to find a lead for a better human neutrophil elastase inhibitor. The plan was to take advantage of the fact that the tripeptide Valine-Proline
