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Background: A wrist-worn wearable device for acquiring limb and chest ECG leads (wECG) may constitute a promising approach to detection of acute myocardial infarction (AMI). However, it remains to be demonstrated whether the information conveyed by the wECG is sufficient for AMI detection. Objective: To explore explainable machine learning models for detecting AMI using the wECG. Methods: Two type
Background Pancreatic enzyme replacement therapy (PERT) prevents malnutrition in people with exocrine pancreatic insufficiency, including those with cystic fibrosis (CF). We developed a lipase that is stable against proteolysis and at the pH of the fed stomach, so it can be taken during a meal to promote mixing of enzyme and substrate. We designed a dose-ranging study of ANG003, a microbial PERT c
Background: The prognostic benefit of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) in stable coronary artery disease (CAD) remains uncertain. Objectives: To evaluate long-term survival following CTO PCI compared with medical therapy (MT) using target trial emulation and a nationwide real-world registry. Methods: We included 7813 patients with stable CAD and a document
The ability to hold listeners’ attention and prevent habituation is a crucial design feature for both biological and human-made distress and alarm signals, but their intrusive nature also causes stress and annoyance. To investigate what makes vocalizations distracting and annoying, we developed Self-Steered Sound Synthesis—a new experimental paradigm for studying voice perception, in which untrain
D-dimer has been proven to be an excellent rule-out marker for acute type A aortic dissection (ATAAD) with a sensitivity exceeding 95% while specificity remains low. We hypothesized that the addition of fibrinogen, which is decreased in ATAAD patients due to consumption coagulopathy, would increase predictive ability. This was an exploratory, retrospective, single-region, observational study compa
Robust and rapid xylose utilization is essential for developing sustainable bioprocesses capable of converting pentose-rich lignocellulosic biomass into renewable chemicals. Saccharomyces cerevisiae is a popular choice for industrial bioprocesses due to its high product yields, robust performance, and stress tolerance. Unfortunately, S. cerevisiae does not natively utilize xylose. Decades of resea
Objective: Dural opening and closures are major steps in endoscopic pituitary surgery. Restoring the normal anatomy at the end of the procedure creates a natural barrier between the intrasellar compartment and the sinonasal cavity. Methods: In this study, we present a relatively simple dural opening and closure technique for endoscopic pituitary surgery. This technique provides a better alternativ
INTRODUCTION: Esophageal squamous cell carcinoma (ESCC) carries a poor prognosis, but earlier tumor detection would improve survival. We aimed to develop and externally validate a risk prediction model based on exposure to readily available risk factors to identify high-risk individuals of ESCC.METHODS: Competing risk regression modeling was used to develop a risk prediction model. Individuals' ab
Introduction: Exposure to environmental chemicals during fetal development may increase the risk of testicular germ cell cancer (TGCC), but few studies have tested the hypothesis. We focused on organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), previously investigated in relation to other male reproductive health outcomes. Methods: We conducted a nested case-control study of 33
Irony is a heavily context-dependent pragmatic phenomenon. But what is it about context that facilitates or blocks irony comprehension? Based on the echoic account, we suggest that a context facilitates irony comprehension when it makes manifest a speaker's intentions and attitude, i.e., when a context makes it easy for participants to engage their mindreading abilities. In two pre-registered self
OBJECTIVE: The primary aim of this study was to confirm the internal consistency and factor structure of the Swedish version of the Swanson-Nolan-Pelham scale fourth edition (SNAP-IV) for parents and to examine its clinical utility for identifying children diagnosed with attention deficit/hyperactivity disorder (ADHD).MATERIALS AND METHODS: Parents of 11-year-old children from a birth cohort in th
Background: Inflammation is a driver of atherosclerosis and susceptibility to cardiovascular events. Objectives: The authors sought to evaluate whether high-sensitivity C-reactive protein (hsCRP) levels are associated with the prevalence of high-risk coronary plaques in patients with non–ST-segment elevation myocardial infarction (NSTEMI). Methods: PROSPECT (Providing Regional Observations to Stud
OBJECTIVE: We previously demonstrated that artificial intelligence (AI)-directed chest computed tomography (CT)-based total opacity scores (TOS) are associated with high-risk obstructive sleep apnea (OSA) based on the Berlin Questionnaire. In the current study, we examined the association between TOS severity and OSA severity based on polysomnography (PSG) recordings among participants with a hist
Context: Land-use intensification to increase yields is often detrimental to biodiversity undermining the provision of ecosystem services. However, it is questionable if ecosystem service providers contribute to ecological intensification by achieving the same or higher yields than conventional high-intensity agriculture. Objectives: In this study, we aimed to disentangle the effects of local and
I Sverige möts vi allt oftare av rubriker om organisationer som hamnat i blåsväder på grund av o lämpliga uttalanden, kränkande reklam eller oetiskt handlande. Dessa firestorms, som ofta uppstår utan förvarning på nätet, medför stora utmaningar för organisationers marknadskommunikationsavdelningar. Denna studie är skriven inom fältet för kriskommunikation och har ämnat att studera dynamiken inom sIn Sweden, we increasingly face headlines where organizations are accused of inappropriate statements, offending ads and unethical actions. These firestorms, which emerge without any warnings, cause major challenges for organizations’ marketing communication. This thesis is written within the field of crisis communication, with an aim to study the dynamics of different Swedish paracrises. The rese
The study of home has historically been approached by numerous academic disciplines within the social sciences and humanities. However, increased international mobility and forced migration due to conflict in recent years has produced a renewed interest to understand the ways we conceptualize and (re)create home in foreign places. The present research aims to produce a theoretical framework that a
Att utveckla kollektivtrafiken är ett viktigt steg för att uppnå de klimatmål Sverige har åtagit sig att följa. Ett verktyg i utformningen och kapacitetsutvecklingen av hållplatserna är trafiksimulering. Detta arbete utforskar hur hållplatser kan på bästa sätt modelleras och kalibreras för fotgängare i programmet Vissim som är en simuleringsmjukvara utvecklad av företaget PTV Group. Vid kalibreriThe development of public transport is an important step toward reaching the climate goals Sweden has set. Traffic simulation is an instrument when developing and designing public transport stops. This thesis investigates how public transport stops can be modeled and calibrated for pedestrians in the PTV groups software Vissim. During the calibration, the platform was divided into four different z
En ordning av naturen given. Den svenska arvsrätten synes nästintill opåverkad av tidens gång. Successionsrättens rötter sträcker sig långt bak i historien. Samhället har genom åren genomgått omfattande förändringar och anpassat sig till nya rådande samhällsstrukturer. Den arvsrättsliga regleringen har däremot förblivit i stort sett oförändrad. Sedan 1300-talet har det enbart funnits fyra versioneAn order given by nature. The Swedish inheritance law appears almost unaffected by the passing of time. The roots of the Swedish succession law extends far back in history. Swedish society has gone through extensive changes over the years in order to adjust to the prevailing social structures, however, the succession regulation seems to have remained almost the same. There has, in fact, only been
Den rättsliga hanteringen av sexualbrott mot barn skiljer sig från den mot vuxna. Hanteringen är särskilt komplicerad vid behandling av sexualbrott mot barn eftersom barn generellt inte kan lämna detaljrika och långa uppgifter vid muntliga utsagor. Detta beror på att deras minneskapacitet, ordförråd och kunskap är begränsad. De kan inte uttrycka sina upplevelser, vilket utgör en svårighet för domsThe legal treatment of sexual offenses against children differs from that against adults. It is particularly complicated in the treatment of sexual offenses against children, as children are generally unable to provide detailed and lengthy information in oral statements. This is because their memory capacity, vocabulary and knowledge are limited. Children experience difficulties in expressing thei
It is a well-known fact that in any Application Specific Integrated Circuit (ASIC) design, verification consumes most time and resources. And when it comes to huge designs, finding bugs can be tedious given the area and the complexity. As per Moore’s law, the design complexity is increasing exponentially due to the growing demand for performance. Therefore, On-Chip communication becomes crucial. T
