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The Role of Surgical Axillary Staging Prior to Immediate Breast Reconstruction in the Era of De-Escalation of Axillary Management in Early Breast Cancer

Postmastectomy radiotherapy (PMRT) following immediate breast reconstruction (IBR) is associated with postoperative complications. Although the incidence of node-positive breast cancer is declining, a separate sentinel lymph node biopsy (SLNB) is still performed before mastectomy when IBR is planned, in order to evaluate nodal status and the need for PMRT. This study assessed the impact of staged

A political ecology of aviation and development : an analysis of relations of power and justice in the (de)construction of Nepal's Second International Airport

In this article, we investigate socio-ecological conflicts surrounding the proposed Second International Airport project near Nijgadh, a town in the southern Terai region of Nepal. Praised by the Nepali government as a gamechanger for Nepal's economy, it has come under scrutiny by environmental activists after plans emerged for extensive clearing of the densely forested project site. While public

Simultaneous 3D T1 and B1+ mapping at 7T using MPRAGE with multiple volumes and driven equilibrium (DE)

MP2RAGE has become popular for T1 mapping at 7T. Accuracy is yet improved by using a separately acquired flip angle map when creating the protocol-specific lookup table. Here, two additional volumes acquired at differing flip angles are added to an MP2RAGE sequence to obtain two separate states of driven equilibriums, effectively forming a dual flip angle protocol within the cycle. By estimating t

Outcry and Whisper (CN, EN, FR, DE & KO)

Shot over an eight-year period, Outcry and Whisper presents itself as a political manifesto for the resistance of women, be they workers, artists, intellectuals or militants, in Chinese and Hong Kong society. Their accounts shine a light on a ferocious battle for independence.

Combining histological grade, TILs, and the PD-1/PD-L1 pathway to identify immunogenic tumors and de-escalate radiotherapy in early breast cancer : A secondary analysis of a randomized clinical trial

Background The implementation of immunological biomarkers for radiotherapy (RT) individualization in breast cancer requires consideration of tumor-intrinsic factors. This study aimed to investigate whether the integration of histological grade, tumor-infiltrating lymphocytes (TILs), programmed cell death protein-1 (PD-1), and programmed death ligand-1 (PD-L1) can identify tumors with aggressive ch

Virtual participatory mapping of nature-based solutions in the Grande de Tárcoles River basin, Costa Rica : Connecting diverse knowledge systems in a context of physical immobility

Co-design processes are of key importance in planning and implementing Nature-based Solutions (NBS), but require boundary management between diverse holders of local, practical and scientific knowledge. Participatory and mapbased planning tools, such as Geodesign workshops, can facilitate such boundary management through mobilising knowledge holders, and translating and negotiating between differe