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Rationale: Untreated obstructive sleep apnea (OSA) is associated with adverse outcomes in patients with coronary artery disease (CAD). Continuous positive airway pressure (CPAP) is the most common treatment, but despite interventions addressing established adherence determinants, CPAP use remains poor. Objectives: To determine whether physiological traits that cause OSA are associated with long-te

The ESS linac will deliver an unprecedented 5 MW of average beam power when completed. Beyond the 90 MeV normal conducting front-end, the acceleration is performed using superconducting structures up to the design energy of 2 GeV. As the ESS will send the beam to a fixed tungsten target, the emittance is not as important a factor as in injectors. However, the losses have to be studied in detail, i

The ESS linac is currently under construction in Lund, Sweden, and once completed it will deliver an unprecedented 5 MW of average power. The ion source and LEBT commissioning starts in 2018 and will continue with the RFQ, MEBT and the frst DTL tank next year and up to the end of the fourth DTL tank in 2020. This paper will summarize the commissioning plans for the normal conducting linac with foc

Objective. To evaluate the Bristol Rheumatoid Arthritis Fatigue Multidimensional Questionnaire (BRAFMDQ), the revised Bristol Rheumatoid Arthritis Numerical Rating Scales (BRAF-NRS V2) and the Rheumatoid Arthritis Impact of Disease (RAID) scale in six countries. Methods. We surveyed RA patients in France, Germany, The Netherlands, Spain, Sweden and the UK, including the HAQ, 36-item Short Form Hea

Alternative oxidase (AOX) is a non-mammalian enzyme that can bypass blockade of the complex III-IV segment of the respiratory chain (RC). We crossed a Ciona intestinalis AOX transgene into RC complex III (cIII)-deficient Bcs1lp.S78G knock-in mice, displaying multiple visceral manifestations and premature death. The homozygotes expressing AOX were viable, and their median survival was extended from

Noninvasive methods for the characterization of shallow subsurface have been used routinely for some 20–30 years. The growth in these methods has been driven by a variety of breakthroughs in the use of electrical, electromagnetic, and seismic methods, to mention only the most common techniques. Increasing field capabilities and computational power have yet to yield all their potential fruits. In t

In 2017, the International Headache Society convened a Global Patient Advocacy Summit (GPAS-1) to begin a collaborative effort involving patients, patient advocates, patient advocacy organizations, healthcare professionals, scientists, professional pain, neurology, and headache societies, pharmaceutical manufacturers, and regulatory agencies to advance issues of importance to patients affected by

BACKGROUND: Empirical knowledge around palliative care provision and needs of people with intellectual disabilities is extremely limited, as is the availability of research resources, including expertise and funding. This paper describes a consultation process that sought to develop an agenda for research priorities for palliative care of people with intellectual disabilities in Europe.METHODS: A

This observational study assessed the relationship between nighttime, early-morning and daytime chronic obstructive pulmonary disease (COPD) symptoms and exacerbations and healthcare resource use. COPD symptoms were assessed at baseline in patients with stable COPD using a standardised questionnaire during routine clinical visits. Information was recorded on exacerbations and healthcare resource u

The reduction of public expenditure and investments in health care provisioning calls for new, sustainable models to transform the increasing aging population and dementia-related diseases incidence from global challenges into new opportunities. In this context, Information and Communication Technologies play a vital role, to both promote aging in place and home management of Patients with Dementi

Background: Historically, endocrine therapy was used in a range of scenarios in patients with rising PSA, both as a treatment for locally advanced non-metastatic prostate cancer and PSA recurrence following curative intended therapy. In the present study the objective was to investigate if chemotherapy added to endocrine therapy could improve progression-free survival (PFS). Materials and Methods:

We present the CarbonTracker Europe High-Resolution (CTE-HR) system that estimates carbon dioxide (CO2) exchange over Europe at high resolution (0.1 × 0.2° ) and in near real time (about 2 months' latency). It includes a dynamic anthropogenic emission model, which uses easily available statistics on economic activity, energy use, and weather to generate anthropogenic emissions with dynamic time pr

Despite growing emphasis on home-based rehabilitation following stroke, there remains limited understanding of how to effectively tailor services to individual needs. This study employed concept mapping to explore diverse stakeholder perspectives on adapting home-based rehabilitation to better support the recovery process after stroke. Through this mixed-methods participatory approach, we engaged

Hydroxyl radicals (HO•), produced through reactions between H2O2 and iron oxides, drive biogeochemical transformations, mediate organism toxicity, and facilitate advanced oxidation processes. The effectiveness of these processes depends on the spatial proximity between HO• generation and target substrates. Consequently, the oxidation mechanisms should be governed by interfacial interactions among

Purpose: Cancer affects a great number of people during working life, and tailored interventions targeting this population are important. The present study, focused on the developmental phase of a work-oriented intervention, aimed to describe work-related experiences and needs among people undergoing curative cancer therapy. Methods: People (n = 22, age md 55 years, range 39–64, purposive sampling

Background: Osteoarthritis (OA) and inflammatory arthritis (IA), including rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondylarthritis (axSpA), are leading causes of disability worldwide, significantly impacting health and quality of life. Sleep issues are highly prevalent in these populations, exacerbating pain, fatigue, and disease activity. However, there is a dearth of evi

High-spin states in 72Br were studied with the EUROBALL III spectrometer using the 40Ca(40Ca,α3p1n) reaction. The negative-parity band observed in this experiment displays a signature inversion around spin I = 16. The interpretation within the cranked Nilsson-Strutinsky approach shows that this signature pattern is a signal of a substantial triaxial shape change with increasing spin where the nucl

Acute myeloid leukemia (AML) arises when leukemia-initiating cells, defined by a primary genetic lesion, acquire subsequent molecular changes whose cumulative effects bypass tumor suppression. The changes that underlie AML pathogenesis not only provide insights into the biology of transformation but also reveal novel therapeutic opportunities. However, backtracking these events in transformed huma