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Despite a variety of testing approaches, it is often difficult to make an accurate diagnosis of Alzheimer's disease (AD), especially at an early stage of the disease. Diagnosis is based on clinical criteria as well as exclusion of other causes of dementia but a definitive diagnosis can only be made at autopsy. We have investigated the diagnostic value of a 96-gene expression array for detection of

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α-Synuclein is a key protein in Parkinson disease. Not only is it the major protein component of Lewy bodies, but it is implicated in several cellular processes that are disrupted in Parkinson disease. Misfolded α-synuclein has also been shown to spread from cell-to-cell and, in a prion-like fashion, trigger aggregation of α-synuclein in the recipient cell. In this mini-review we explore the evide

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The aim of this study was to estimate rates and type of definitive surgical interventions for nephrolithiasis in Swedish patients with ankylosing spondylitis (AS) compared to the general population.

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The ecological debt concept emerged in the early 1990s from within social movements driven by rising environmental awareness, emerging Western consciousness of responsibility for past colonial subjugations, and a general sense of unease during the debt crisis. First developed organically, mainly in locally-scaled, civil contexts, ecological debt has since gained attention in academia and internati

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The number of triangulations of a planar n point set S is known to be c^n, where the base c lies between 2.43 and 30. Similarly, the number of spanning trees on S is known to be d^n, where the base d lies between 6.75 and 141.07. The fastest known algorithm for counting triangulations of S runs in O^∗(2^n) time while that for counting spanning trees runs in O^∗(7.125^n) time. The fastest known arb

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To study and identify early clinical and radiological findings that could help to predict operative intervention for small bowel obstruction. One hundred and nine consecutive patients with small bowel obstruction who underwent small bowel follow-through examination with Gastrografin(A (R)) during 2005-2006. The patients were divided into an operative group and a non-operative group, n = 44 and 65,

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We use time-dependent density functional theory together with a set of extensive multidimensional visualization techniques to characterize band gap, optical absorption properties, intramolecular and intern-wreaths charge transfer, exciton binding energy, charge transfer integral, and the rate of charge transfer and recombination in the PC60BM:PDDTT Model of an organic,solar cell. These theoretical

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How does an individual decision maker update his or her beliefs in the light of others’ beliefs? We present an empirical investigation that varies decision makers’ access to other peoples’ beliefs: whether they know what course of action others have taken (in this case how a problem is solved) and whether they know why this course of action was taken (why a particular solution is preferred).We pro

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Of the 287 000 maternal deaths every year, 99% happen in low- and middle-income countries. The vast majority could be averted with timely access to appropriate emergency obstetric care (EmOC). The proportion of women with complications of pregnancy or childbirth who actually receive treatment is reported as 'Met need for EmOC'.

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This work describes a new diffusion MR framework for imaging and modeling of microstructure that we call q-space trajectory imaging (QTI). The QTI framework consists of two parts: encoding and modeling. First we propose q-space trajectory encoding, which uses time-varying gradients to probe a trajectory in q-space, in contrast to traditional pulsed field gradient sequences that attempt to probe a

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The popliteal artery (PA) is, after aorta, the most common site for aneurysm formation. Why the PA is more susceptible than other peripheral muscular arteries is unknown. We hypothesized that the wall composition, which in turn affects wall properties, as well as the circumferential wall stress (WS) imposed on the arterial wall, might differ compared to other muscular arteries. The aim was to stud

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In this work, we model the basic mechanisms of the interaction between phase-transformations and plasticity within a one-dimensional constitutive framework. Efficient algorithms are presented, facilitating to solve the underlying evolution equations with high numerical stability at low numerical costs. Furthermore, a family of functions covering physically reasonable classes for the inheritance of

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The use of test-coverage measures (e.g., block-coverage to control the software test process has become an increasingly common practice. This is justified by the assumption that higher test-coverage helps achieve higher defect-coverage and therefore improves software quality. In practice, data often show that defect-coverage and test-coverage grow over time, as additional testing is performed. How

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The first subject addressed in this thesis is the contribution of the VSAT luminosity to the lineshape analysis, i.e. to the extraction of the mass and width of the Z0 boson from LEP1 DELPHI data. The VSAT detector has contributed to the lineshape parameter determination by providing a relative luminosity measurement of high accuracy. The second subject of the thesis is the extraction of the helic

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Construction in rock is associated with risks because knowledge of the geology and ground conditions is limited. Unforeseen rock conditions involve a large risk to the project and can in the end entail delays and extra costs. To minimize the risks, an optimized pre-investigation program has to be conducted where essential information is gathered in order to make the best decisions throughout the c