Sökresultat

Symptoms of fecal incontinence and constipation are common in the general population. These can, however, be unreliably reported and are poorly discriminatory for underlying pathophysiology. Furthermore, both symptoms may coexist. In the elderly, fecal impaction always must be excluded. For patients with constipation, colon transit studies, anorectal manometry and defecography may help to identify

Integrated Water Resources Management (IWRM) is a relatively new approach in Bolivia. However, it is now generally accepted that this approach needs to be established in order to find sustainable solutions for development and is actively promoted by the Water Ministry, especially in environmentally fragile regions, such as the Lake Poopo basin. The Lake Poopo basin is one of the poorest regions in

Background: This phase II study evaluated the safety and activity of ipilimumab, a fully human mAb that blocks cytotoxic T-lymphocyte antigen-4, in patients with advanced melanoma. Patients and methods: Patients with previously treated, unresectable stage III/stage IV melanoma received 10 mg/kg ipilimumab every 3 weeks for four cycles (induction) followed by maintenance therapy every 3 months. The

Background: Enhancement of enzymatic digestibility by some supplementations could reduce enzyme loading and cost, which is still too high to realize economical production of lignocellulosic biofuels. A recent study indicates that yeast hydrolysates (YH) have improved the efficiency of cellulases on digestibility of furfural residues (FR). In the current work, the components of YH were separated by

Objective To examine whether erosive hand osteoarthritis (OA) is associated with knee subchondral bone attrition (SBA) and systemic bone mineral density (BMD). Methods Associations of MRI-defined knee SBA with radiographic erosive hand OA were evaluated in 1253 Framingham participants using logistic regression with generalised estimating equations. We also examined the association between the numb

Moving to a new country and living in a new culture involves many processes of change and adaptation for the individual. Not only is the person surrounded by a new language, different norms, behaviour and traditions, but suddenly he or she is also an “immigrant” in this new society. This study was set out to examine the experience of being an immigrant in Sweden, with the aim to make the Swedish s

This study was performed using daily spot prices, from January 1997 through July 2004; of the three assets that constitute the crack spread i.e. crude oil, gasoline and heating oil - all listed on the New York Mercantile Exchange (NYMEX). Our objective has been to characterize the dynamics of the spread and subsequently create trading strategies to yield returns that surpass that of a passive appr

This master thesis is commissioned by the company Haldex Brake Products AB based in Landskrona. The company is acting on the road vehicle market. Amongst other products the company produces disc brakes for the heavy road vehicle industry. Disc brakes developed by Haldex, based on the sliding caliper principle, are during certain circumstances experiencing problems with malfunction of the brake due

The Criminal Code describes rape as an obvious involuntarily. It has been proven to be a problem in the Swedish judiciary to suggest that rape victims often receive degrading questions and a censure treatment. This study has focused on how the encounter between the police and rape victims is like. The purpose of it was to get a picture of how both police and victims are experiencing the encounter.

Problem discussion: Industrial segmentation based on strategy requires a new course of action. How will overarching variables be chosen if the segmented objects change continuously? With which strategic sub variables will sub segments be created? Purpose: The theoretical purpose is to identify requirements on variables within segmentation of existing customers in industrial markets. Furthermore, i

The aim of this study was to examine how women's shelters provide children's need for support and assistance and how they work with the child perspective. I chose to use a qualitative method with semi-structured interviews. I have done six interviews; I did one interview by the telephone and one by email. The other interviews were done on the current women’s shelter. The tools I used durin

Background: Small bowel neuroendocrine tumours often present with locally advanced or metastatic disease. The aim of this paper is to provide evidence-based recommendations regarding (controversial) topics in the surgical management of advanced small bowel neuroendocrine tumours. Methods: A working group of experts was formed by the European Society of Endocrine Surgeons. The group addressed 11 cl

The evolution of compact groups of galaxies may represent one of the few places in the nearby universe in which massive galaxies are being forged through a complex set of processes involving tidal interaction, ram-pressure stripping, and perhaps finally "dry mergers" of galaxies stripped of their cool gas. Using collisionless N-body simulations, we propose a possible scenario for the formation of

In the passive solar water heater, temperature stratification is a valuable thermodynamic parameter for horizontal water storage tanks. This investigation aims to optimize the deflector and numerically study the effects of various deflector lengths and materials on temperature stratification of a horizontal water storage tank during natural convection. Firstly, comparative thermal performances of

Metachromatic leukodystrophy (MLD) is a fatal, progressive neurodegenerative disorder caused by biallelic pathogenic mutations in the ARSA (Arylsulfatase A) gene. With the advent of presymptomatic diagnosis and the availability of therapies with a narrow window for intervention, it is critical to define a standardized approach to diagnosis, presymptomatic monitoring, and clinical care. To meet the

Amyloid-β (Aβ) positron emission tomography (PET) imaging and cerebrospinal fluid (CSF) biomarkers are now established tools in the diagnostic workup of patients with Alzheimer's disease (AD), and their use is anticipated to increase with the introduction of new disease-modifying therapies. Although these biomarkers are comparable alternatives in research settings to determine Aβ status, biomarker

Molecular subtyping of pulmonary large-cell neuroendocrine carcinoma (LCNEC) based on retinoblastoma protein (pRb) expression may influence systemic treatment decisions. Current histomorphologic assessments of hematoxylin and eosin–stained tissue samples cannot reliably differentiate LCNEC molecular subtypes. This study explores the potential of deep learning (DL) to identify histologic patterns t

Global policies, legislation, and eco-friendly initiatives have induced the steel industry to integrate sustainable development approaches. Sustainability requires all phases from raw material sourcing to transportation to waste and carbon footprint elimination—yielding positive effects. This research employs a two-step approach in sustainability. The first phase entails conducting a systematic li

The increasing global concern for greenhouse gas emissions has led to a fast pace in the transition away from fossil fuels in the transport sector. The share of electric passenger cars is increasing quickly, introducing new loads on the power grid. These loads primarily appear at the distribution grid level, where most of the charging occurs in the form of overnight charging at home. Although the