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Generation of iPSC Lines with Tagged α-Synuclein for Visualization of Endogenous Protein in Human Cellular Models of Neurodegenerative Disorders

α-Synuclein is a synaptic protein that accumulates primarily in synucleinopathies and secondarily in certain lysosomal storage disorders. However, its physiological roles in health and disease are not fully understood. In part, this has been hampered by the inability to visualize α-synuclein and its cellular localization, due to the lack of specific antibodies and faithful reporters. Here, we used

RADIO FREQUENCY IDENTIFICATION: THE TECHNOLOGY AND SUPPLY CHAIN APPLICATION

The Radio Frequency Identification (RFID) is quite a vast subject. It is used for so many different applications. The most developed area of research has first been to track animals. Nowadays, many pets have a chip hidden in their neck that permits to identify them very specifically as the information in the chip is unique. Some researches have then been oriented on the supply chain area. Unfortu

Socialarbetaren i organisationen: Anpassning eller inflytande?

The aim of this paper was to examine how social workers' comprehension of the need of financial aid exists in, and is influated by, the organisation they work in. To investigate this, we asked ourself questions concerning how the social worker view the way that the finicial aid-system and work surrounding it is formed, whether the social worker's understanding of the need of financial aid

Implementering av Funktionell Familjeterapi: en kvalitativ studie av implementeringen av en evidensbaserad behandlingsmetod inom socialtjänsten på en ort i södra Sverige

The ambition to use evidence based treatments has spread within the field of Swedish social work. The number of treatments with claim to being evidence based has grown but the research concerning implementation; the procedures being used to introduce new methods in organizations and assure that the method is being used appropriately and continuously, is scarce. The aim of this study was to examine

Konsten att förutspå konjunkturen - Hur användbara är enkätbaserade snabbindikatorer?

Foreseeing future changes in economic activity is of up most importance to a wide array of actors. The time lag in the presentation of official GDP statistics means that to somewhat accurately capture a tendency of where the business cycle is heading one need turn to qualitative sentiment indicators such as Purchasing Managers’ Index (PMI) and official sentiment indicators for valuable clues. This

National Readiness for E-learning

In this thesis a comparative study of Sweden and Thailand was conducted in order to find out why Sweden is top-ranked and Thailand low-ranked on an e-learning readiness scale. More specifically, I was focusing on the net universities in Sweden and in Thailand. The net universities and the countries were contrasted in order to find out, not only if the differences or similarities had any influence

Public WLAN - The interaction between venues and WISPs

Purpose: The purpose is to research different co-operations between venue owners and WISPs, when WLAN is deployed in a public space. The aim is to establish viable business models for the interaction between the two vital actors in the public WLAN industry. In this work, the advantages and disadvantages of revenue and cost sharing will be defined, along with technical and commercial issues that ne

Measuring motivation using the transtheoretical (stages of change) model : A follow-up study of people who failed an online hearing screening

Abstract: Objective: Acceptance and readiness to seek professional help have shown to be important factors for favourable audiological rehabilitation outcomes. Theories from health psychology such as the transtheoretical (stages-of-change) model could help understand behavioural change in people with hearing impairment. In recent studies, the University of Rhode Island change assessment (URICA) ha

Docforia: A Multilayer Document Model

In this paper, we describe Docforia, a multilayer document model and application programming interface (API) to store formatting, lexical, syntactic, and semantic annotations on Wikipedia and other kinds of text and visualize them. While Wikipedia has become a major NLP resource, its scale and heterogeneity makes it relatively difficult to do experimentations on the whole corpus. These experimentat

The Effectiveness of Psychosocial Interventions as Adjuncts to Orthopaedic Surgery : A Systematic Review Protocol

Aims: Pain and anxiety are commonly reported among those undergoing orthopaedic surgery. Improvement in anxiety and pain control might be achieved by supplementing standard care with psychological interventions. However, the effectiveness of adjunctive psychosocial interventions in anxiety and pain control have not been addressed sufficiently by previous systematic reviews in orthopaedic surgeries

Assessing vector navigation in long-distance migrating birds

Birds migrating between distant locations regularly perform long continuous flights lasting several days. What compass mechanism they use is still a mystery. Here, we use a novel approach, applying an individual-based model, taking compass mechanisms based on celestial and geomagnetic information and wind into account simultaneously, to investigate what compass mechanism likely is used during long

Information, social support and coping in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension-A nationwide population-based study

Objective: Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) decrease life expectancy for affected patients. The aim was to describe the perceptions of received information regarding diagnosis, treatment and management, as well as social support and coping perceived by patients with PAH or CTEPH. Methods: A descriptive, national cohort survey that incl

Networking our science to characterize the state, vulnerabilities, and management opportunities of soil organic matter

Soil organic matter (SOM) supports the Earth's ability to sustain terrestrial ecosystems, provide food and fiber, and retains the largest pool of actively cycling carbon. Over 75% of the soil organic carbon (SOC) in the top meter of soil is directly affected by human land use. Large land areas have lost SOC as a result of land use practices, yet there are compensatory opportunities to enhance prod

Heparin-binding protein, lysozyme, and inflammatory cytokines in bronchoalveolar lavage fluid as diagnostic tools for pulmonary infection in lung transplanted patients

Pulmonary infection is a common complication after lung transplantation, and early detection is crucial for outcome. However, the condition can be clinically difficult to diagnose and to distinguish from rejection. The aim of this prospective study was to evaluate heparin-binding protein (HBP), lysozyme, and the cytokines interleukin (IL)-1β, IL-6, IL-8, IL-10 and tumor necrosis factor (TNF) in br

Comparative proteome analysis of thalamus in MK-801-treated rats

Two-dimensional gel-electrophoresis in combination with mass spectrometry is a powerful approach to compare protein expression in brain tissues. Using this proteomic approach, and based on the hypothesis that schizophrenia involves hypoglutamergic brain function, alterations in protein levels in the thalamus of rats treated with the N-methyl-D-aspartate (NMDA) receptor antagonist [+]-5-methyl-10,1

The relevance of personality traits in impulsivity-related disorders : From substance use disorders and gambling disorder to bulimia nervosa

Background and aims: The main aim of this study was to analyze and describe the clinical characteristics and shared personality traits in different impulsivity-compulsivity spectrum disorders: substance use disorders (SUD), gambling disorder (GD), and bulimia nervosa (BN). The specific aims were to compare personality differences among individuals with pure SUD, BN with and without SUD, and GD wit

Waste policies gone soft : An analysis of European and Swedish waste prevention plans

This paper presents an analysis of European and Swedish national and municipal waste prevention plans to determine their capability of preventing the generation of waste. An analysis of the stated objectives in these waste prevention plans and the measures they propose to realize them exposes six problematic features: (1) These plans ignore what drives waste generation, such as consumption, and (2