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Background. Umbilical artery Doppler velocimetry is a routine method for fetal surveillance in high-risk pregnancy. Uterine artery Doppler seems to give comparable information, but it can be difficult to interpret as there are two arteries, which might show notching and/or increased pulsatility index (PI) as signs of increased vascular impedance. Combining the information on vascular resistance on
A novel design of a biochemical oxygen demand (BOD) biosensor has been developed for on-line monitoring of easily biodegradable organic compounds in aqueous samples. The biological recognition element of the sensor could be easily renewed by injecting new bacterial paste without disassembling the sensor system. The sensor measurements were carried out in the initial-rate mode using a flow injectio
Background In vivo measurement of wear in the ball and socket articulation of total hip arthroplasties is of interest in the evaluation of both existing and new implants. Controversy reigns regarding the accuracy of different radiological measurement techniques and in particular how accuracy has been assessed. Material and methods We assessed the accuracy of 2 radiostereometric (RSA) techniques f
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Vilka är egentligen ”de äldre”? Vad innebär det att vara pensionär? Hur ska man åldras på rätt sätt? Frågor som dessa har under det nyss avslutade århundradet ställts och besvarats på många oliks sätt, beroende av sammanhang och tidsperiod. I vissa situationer har de äldres olikhet lyfts fram, i andra deras likhet. Ibland har åldrandetThe aim of the dissertation is to describe images of old age in the magazines of Sweden’s two largest pensioner organizations, and explain the character of those images in relation to the temporal contexts of the organizations and their aim to act as the representatives of pensioners. The study is based on the 329 and 330 magazines (1941–1995) that the organizations have submitted to attract membe
This study is about how the 'global' becomes localized and how the 'local' is articulated through the 'global'. It deals with the Van (forest) Gujjars, a people of nomadic forest pastoralists who inhabit the Central Himalayas of India. The study has two main foci: One is the everyday life-world of the Van Gujjars in the forest - a Van Gujjar ethnography - and the other is the conflict over 'conser
BACKGROUND AND AIMS: The optimal position for pH electrode placement in the diagnosis of gastroesophageal reflux disease (GERD) is unknown. The aim of this study was to evaluate the discriminatory power of targeted pH recording immediately above the squamocolumnar junction (SCJ) and to compare the results with those obtained by simultaneous recording at the conventional level for pH monitoring. SU
Background: nonacog beta pegol (N9-GP) is a glycoPEGylated recombinant factor IX (rFIX) molecule with a prolonged half-life. Objectives: To provide information on potential dose regimens for N9-GP for phase 3 pivotal and surgery trials. Methods: A population pharmacokinetic model was developed from single-dose data derived from the first human dose trial with N9-GP in hemophilia B patients, and wa
EPIC-Heart is the cardiovascular component of the European Prospective Investigation into Cancer and Nutrition ( EPIC), a multi-centre prospective cohort study investigating the relationship between nutrition and major chronic disease outcomes. Its objective is to advance understanding about the separate and combined influences of lifestyle ( especially dietary), environmental, metabolic and genet
Gemcitabine has been the standard chemotherapeutic agent in pancreatic cancer. However, two-thirds of pancreatic tumors display low expression of human equilibrative nucleoside transporter 1 (hENT1), which mediates cellular entry of the drug, and do not respond to gemcitabine therapy. The objective was to determine the costs of gemcitabine overtreatment and the cost-effectiveness of hENT1 testing
Background. Drug abuse (DA) is a clinically heterogeneous syndrome. Using medical, legal, death and pharmacy records covering the entire population of Sweden, could we uncover meaningful subtypes of DA? Method. We performed a latent class analysis (LCA) on all individuals in Sweden born 1950-1993 who were registered with DA or its consequences (n=192 501) and then validated these classes using dem
The need for new renewable products has enhanced the interest in cellulose and hemicellulose as raw material. The wood plant cell wall is a complex mixture of cellulose, hemicellulose, lignin and minor amounts of pectin, proteins and extractives. Several interactions between the compounds make them difficult to separate without modification. O-acetyl-galactoglucomannan (O-acetyl-GGM), the major he
Popular Abstract in Swedish När ett barn föds före graviditetsvecka 30 är andningsinsufficiens eller på engelska kallad respiratory distress syndrome (RDS) ett av de stora kliniska problemen som barnläkaren står inför. Redan på 1920-talet förstod man att det måste finnas ett ytspänningsnedsättande ämne i lungorna och på 1950-talet fann man att för tidigt födda (prematura) barn med RDS hade brist p
Prostate-specific antigen (PSA) is a glycoprotein produced by the prostate gland. It occurs in several molecular forms in the blood and assays have been developed to measure free PSA and PSA in complex with alpha-1-antichymotrypsin (PSA-ACT). Higher proportions of free PSA (PSA-F/T) in blood are found in subjects with benign prostatic hyperplasia (BPH) as compared to cancer patients. Utilizing imm
Purpose: To study the impact of dose fractionation of adjuvant radiation therapy (RT) on local recurrence (LR) and the relation of LR to radiation fields. Methods and Materials: LR rates were analyzed in 462 adult patients with soft tissue sarcoma who underwent surgical excision and adjuvant RT at five Scandinavian sarcoma centers from 1998 to 2009. Medical records were reviewed for dose fractiona
PURPOSE: To analyze the visual outcome after cataract surgery. SETTING: Cataract surgery clinics in 15 European countries. DESIGN: Database study. METHODS: Data were drawn from case series of cataract extractions reported to the European Registry of Quality Outcomes for Cataract and Refractive Surgery database. These data were entered into the database via the Web by surgeons or by transfer from e
High and low pollen deposition years in the period 1998-2010 were recorded for ten forest-forming trees in Roztocze (SE Poland) using Tauber-style traps. The coincidence of very high/low pollen deposition years recorded in Tauber traps and aerobiological data obtained by volumetric samplers shows that these phenomena occur simultaneously in different places across vast areas of a tree's distributi
