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Immunological control of residual leukemia cells is thought to occur in patients with chronic myeloid leukemia (CML) that maintain treatment-free remission (TFR) following tyrosine kinase inhibitor (TKI) discontinuation. To study this, we analyzed 55 single-cell RNA and T cell receptor (TCR) sequenced samples (scRNA+TCRαβ-seq) from patients with CML (n = 13, N = 25), other cancers (n = 28), and he

BackgroundPolypharmacy has been linked with social isolation and loneliness among older people. The roles of different medication groups to this association are unclear. The aim of this study was to examine associations of fall-risk-increasing drugs (FRIDs) and cardiovascular drugs with loneliness and social isolation.MethodsThis cross-sectional study included 6714 adults aged 60 years and above l

The survival rate of patients with glioma has not significantly increased in recent years despite aggressive treatment and advances in immunotherapy. The limited response to treatments is partially attributed to the immunosuppressive tumor microenvironment, in which regulatory T cells (Treg) play a pivotal role in immunologic tolerance. In this study, we investigated the impact of complement facto

Attempts to use colloid science concepts to better understand the dynamic properties of concentrated or crowded protein solutions are challenging due to the fact that globular proteins generally have heterogeneous surfaces that result in anisotropic or patchy contributions to their interaction potential. This is particularly difficult when targeting non-equilibrium transitions such as glass and ge

Background: Problem gambling and gambling disorder cause severe social, psychiatric, and financial consequences, and voluntary self-exclusion is a common harm reduction tool used by individuals with gambling problems. Objective: The aim of this study was to explore users’ experience of a novel nationwide, multioperator gambling self-exclusion service, “Spelpaus,” in Sweden and to inform stakeholde

BackgroundPresence of a prosthetic joint entails a life-long risk of haematogenous periprosthetic joint infection (hPJI) during bacteraemia. For bacteraemia with Staphylococcus aureus the hPJI frequency has been described to be up to 40% and for streptococci up to 20%, with large variation among reported frequencies.ObjectivesWe aimed to investigate the hPJI frequency from bacteraemia with virulen

Background: Providing evidence-based interpretative comments (IC) is an integral task of clinical laboratory professionals. It may be of special relevance for coagulation testing, where pathological first-line tests could trigger more specialized tests. Our aim was to evaluate the quality of ICs provided to the physician in two samples with activated partial thromboplastin time (APTT) prolongation

Directed evolution has revolutionized protein engineering. Still, enzyme optimization by random library screening remains sluggish, in large part due to futile probing of mutations that are catalytically neutral and/or impair stability and folding. FuncLib is a novel approach which uses phylogenetic analysis and Rosetta design to rank enzyme variants with multiple mutations, on the basis of predic

The theory of evolution is one of the greatest scientific achievements in the intellectual history of humankind, yet it is still contentious within certain social groups. Despite being as robust and evidence-based as any other notable scientific theory, some people show a strong reluctance to accept it. In this study, we used the Measure of Acceptance of the Theory of Evolution (MATE) and Knowledg

Background: Even though children after tonsil surgery experience pain and other limitations in their daily lives, nursing care is transferred to parents after tonsil surgery, and they might need some kind of support. The aim of the study was to test the design of a randomized controlled trial intended to evaluate a nurse-led telephone follow-up after tonsil surgery on postoperative symptoms and qu

Context. Star clusters, composed of stars born from the same molecular cloud, serve as invaluable natural laboratories for understanding the fundamental processes governing stellar formation and evolution. Aims. This study aims to investigate correlations between the Mean Interdistance (Di), Mean Closest Interdistance (Dc) and Median Weighted Central Interdistance (Dcc) with the age of star cluste

Background: Regardless of the indisputable benefits of insulin therapy, initiating insulin for newly diagnosed type-1 children with diabetes might be intimidating for parents. This study assesses the experience, fears, barriers and adherence to insulin use among the parents of early-diagnosed children with diabetes. Methods: A cross-sectional online survey was utilized for data collection from 218

Glioblastoma (GBM) is the most aggressive form of glioma with a high rate of relapse despite intensive treatment. Tumor recurrence is tightly linked to radio-resistance, which in turn is associated with hypoxia. Here, we discovered a strong link between hypoxia and local complement signaling using publicly available bulk, single-cell, and spatially resolved transcriptomic data from patients with G

Inequalities of opportunity affect a person’s life expectancy and access to basic services and human rights through discrimination, abuse, and lack of access to justice. High levels of inequality of opportunity discourage skill accumulation, choke economic and social mobility, and, consequently, depress economic growth. Inequality also entrenches uncertainty, vulnerability, and insecurity; undermi

Background: Among non-communicable disorders (NCDs), stroke remains the second leading cause of death and the third leading cause of death and disability combined (as expressed by disability-adjusted life-years lost—DALYs) in the world. Aims: The study was aimed to estimate global, regional and nationa burden of stroke and its risk factors from 1990 to 2021. Methods: Finding presented in this pape

Nonlinear phenomena (NLP) are often associated with high arousal and function to grab attention and/or signal urgency in vocalizations such as distress calls. Although biomechanical models and in vivo/ex vivo experiments suggest that their occurrence reflects the destabilization of vocal fold vibration under intense subglottal pressure and muscle tension, comprehensive descriptions of the dynamics