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Glioblastoma (GBM) is the most aggressive form of glioma with a high rate of relapse despite intensive treatment. Tumor recurrence is tightly linked to radio-resistance, which in turn is associated with hypoxia. Here, we discovered a strong link between hypoxia and local complement signaling using publicly available bulk, single-cell, and spatially resolved transcriptomic data from patients with G

Inequalities of opportunity affect a person’s life expectancy and access to basic services and human rights through discrimination, abuse, and lack of access to justice. High levels of inequality of opportunity discourage skill accumulation, choke economic and social mobility, and, consequently, depress economic growth. Inequality also entrenches uncertainty, vulnerability, and insecurity; undermi

Background: Among non-communicable disorders (NCDs), stroke remains the second leading cause of death and the third leading cause of death and disability combined (as expressed by disability-adjusted life-years lost—DALYs) in the world. Aims: The study was aimed to estimate global, regional and nationa burden of stroke and its risk factors from 1990 to 2021. Methods: Finding presented in this pape

The Andes mountains extend north–south in a latitudinal gradient of 8500 km. Because of the great climatic variety and the peculiar north–south orographic distribution, lakes are highly diverse, including different lake origins and contrasting morphometries. We reviewed >700 ecological studies on Andean lakes to identify the main threats to these freshwater systems. The most important threats are

There is a growing interest in reconstructing the density matrix of photoelectron wavepackets, in particular in complex systems where decoherence can be introduced either by a partial measurement of the system or through coupling with a stochastic environment. To this end, several methods to reconstruct the density matrix, quantum state tomography protocols, have been developed and tested on photo

The ringing and controlling of previously marked birds are invaluable tools for studying the survival, productivity, and movement of birds. To maximize the value of ringing data, it is important to minimize any potential biases. For some species, such as nestbox-breeding owls, ringing records are typically heavily skewed toward females because they generally are easier to catch. The use of traditi

Medical image segmentation is a critical component in a wide range of clinical applications, enabling the identification and delineation of anatomical structures. This study focuses on segmentation of anatomical structures for 3D printing, virtual surgery planning, and advanced visualization such as virtual or augmented reality. Manual segmentation methods are labor-intensive and can be subjective

Understanding the processes that drive phenotypic diversification and underpin speciation is key to elucidating how biodiversity has evolved. Although these processes have been studied across a wide array of clades, adaptive radiations (ARs), which are systems with multiple closely related species and broad phenotypic diversity, have been particularly fruitful for teasing apart the factors that dr

Background: Acute appendicitis is one of the most common causes of acute abdominal pain. Differences in the management of this large group of patients has important consequences for the patients and the healthcare system. Controversies regarding the understanding of the natural course of the disease, the utility of new diagnostic methods, and alternative treatments have lead to large variations in

In celebration of the excellence of articles published in the Journal of Comparative Physiology A, Editors’ and Readers’ Choice Awards are annually conferred to the top papers in the categories Original Research Paper and Review/Review-History Article. The recipients of the 2025 Editors’ Choice Awards were selected based on votes cast by the Editorial Board on articles published in 2024. In the ca

Children with hemophilia have a significantly higher risk of intracranial hemorrhage (ICH) compared to the normal population. Prophylaxis reduces the risk of ICH and earlier initiation of prophylaxis may now be feasible, especially in hemophilia A (HA). The aim of the study is to explore the potential for preventing ICH by earlier start of prophylaxis by assessing the natural course of ICH before

A review of existing life cycle assessments on food waste management was made with two main aims. Firstly, to make an overview of the assessments of the global warming potential from the treatment alternatives incineration, landfill, anaerobic digestion and compost in studies reported in literature. Secondly, to identify decisive factors in general and related to system boundary settings in partic

Plasma p-tau217 and tau positron emission tomography (PET) are strong prognostic biomarkers in Alzheimer’s disease (AD), but their relative performance in predicting future cognitive decline among cognitively unimpaired (CU) individuals is unclear. In a head-to-head comparison study including nine cohorts and 1,474 individuals, we show that plasma p-tau217 and medial temporal lobe tau-PET signal d

AIMS: We aimed to investigate major adverse cardiac events (MACE: defined as all-cause mortality, re-infarction, and stroke), length of hospital stays (LOS), and comorbidities following acute coronary syndrome (ACS) in a population with schizophrenia.METHODS AND RESULTS: This Danish register study included patients diagnosed with ACS in the period between 1995 and 2013 with a preceding diagnosis o

Group A rotaviruses can infect both humans and animals. Individual rotavirus strains can occasionally cross species barriers and might hereby contribute to the emergence of new genotypes in heterologous hosts. The incidence and impact of zoonotic rotavirus are not well defined, and one reason for this is a lack of data about strains circulating in suspected reservoir animal hosts. In this study we

The sexuality of hivinfected people is quite controversial but nevertheless important when speaking of hivprevention. The aim of this work was to survey and analyze support and counseling practices around sexual issues given to hivpositive people by their treating medical doctors. We wanted to bring the question of hivinfected peoples sexuality and sexual behavior sometimes unprotected and the Swe

The aim of this study was to examine the view of social service workers on the secondary housing market based upon their work with social investigations regarding people with a difficult substance abuse. The foundation of this study rests upon a phenomenon, which according to other scholars, occurs in the secondary housing market in Sweden. The secondary housing market consists of a multitude of h

Close to the city center of Reykjavik lies the combined national- and university library of Iceland. Usually, these two types of institutions are separated. The purpose of this essay is to investigate how the library in fact selects the new digital material to offer the users in Iceland, and if the combined mission creates any problems or conflicts. The investigation examines the planning and the

Centre for Economic Demography Lund University School of Economics and Management P.O. Box 7080 SE-220 07 Lund, Sweden www.ed.lu/publications/Lund-Papers-in-Economic-Demography/ Stayers and Movers: A study on emigration from Sweden 1990-2014 DEBORA PRICILA BIRGIER, CHRISTER LUNDH, YITCHAK HABERFELD, ERIK ELLDÉR LUND PAPERS IN ECONOMIC DEMOGRAPHY 2021:5 http://www.ed.lu/publications/Lund-Papers-in-

https://www.lusem.lu.se/sites/lusem.lu.se/files/2024-07/LPED%202021%205.pdf - 2026-06-12