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Live well, die well - an international cohort study on experiences, concerns and preferences of patients in the last phase of life: the research protocol of the iLIVE study
Introduction Adequately addressing the needs of patients at the end of life and their relatives is pivotal in preventing unnecessary suffering and optimising their quality of life. The purpose of the iLIVE study is to contribute to high-quality personalised care at the end of life in different countries and cultures, by investigating the experiences, concerns, preferences and use of care of termin
Spinning forward and digging deeper : agency and changing institutions in old industrial regions
This paper highlights changes in perceived room for agency and local institutions (formal and informal) in old Swedish mill regions. The paper draws on recent literature on change agency (Grillitsch & Sotarauta, 2020) and reproductive agency (Bækkelund, 2021; Jolly et al., 2020) as well as the role of institutions in local communities (Bole, 2021; Rodríguez-Pose, 2013) and builds on material f
Increase in protandry over time in a long-distance migratory bird
Protandry is a widespread life-history phenomenon describing how males precede females at the site or state of reproduction. In migratory birds, protandry has an important influence on individual fitness, the migratory syndrome, and phenological response to climate change. Despite its significance, accurate analyses on the dynamics of protandry using data sets collected at the breeding site, are l
Amyloid-β peptide 37, 38 and 40 individually and cooperatively inhibit amyloid-β 42 aggregation
Use of mass spectrometry to determine the diversity of toxins produced by gambierdiscus and fukuyoa species from Balearic Islands and Crete (Mediterranean Sea) and the Canary Islands (Northeast Atlantic)
The implementation of systematic monitoring of cognition in children with cerebral palsy in Sweden and Norway
PURPOSE: Children with cerebral palsy (CP) are at risk of cognitive impairments and need to be cognitively assessed to allow for individualized interventions, if applicable. Therefore, a systematic protocol for the follow-up of cognition in children with CP, CP Cog, with assessments offered at five/six and 12/13 years of age, was developed. This report presents and discusses assessment practices i
Findzx : an automated pipeline for detecting and visualising sex chromosomes using whole-genome sequencing data
Background: Sex chromosomes have evolved numerous times, as revealed by recent genomic studies. However, large gaps in our knowledge of sex chromosome diversity across the tree of life remain. Filling these gaps, through the study of novel species, is crucial for improved understanding of why and how sex chromosomes evolve. Characterization of sex chromosomes in already well-studied organisms is a
Rapid measurement of heteronuclear transverse relaxation rates using non-uniformly sampled R1ρ accordion experiments
Multidimensional, heteronuclear NMR relaxation methods are used extensively to characterize the dynamics of biological macromolecules. Acquisition of relaxation datasets on proteins typically requires significant measurement time, often several days. Accordion spectroscopy offers a powerful means to shorten relaxation rate measurements by encoding the “relaxation dimension” into the indirect evolu
Rosiglitazone treatment enhances intracellular actin dynamics and glucose transport in hypertrophic adipocytes
Effects of Increasing Salinity by Drip Irrigation on Total Grain Weight Show High Yield Potential of Putative Salt-Tolerant Mutagenized Wheat Lines
Twenty-three lines from a mutagenized Bangladeshi BARI Gom-25 wheat population that included previously identified salt-tolerant lines, and the BARI Gom-25 control variety, were cultivated in a drip-irrigated salinity test field at Salt Farm Texel, Netherlands, to assess their performance during salt stress in European climatic conditions. Lines were tested at irrigation salinity levels of 1, 4, 8
Validation of a computational chain from PET Monte Carlo simulations to reconstructed images
The study aimed to create a pipeline from Monte Carlo simulated projections of a Gate PET system to reconstructed images. The PET system was modelled after the GE Discovery MI (DMI) PET/CT, and the simulated projections were reconstructed with the stand-alone reconstruction software CASToR. Attenuation correction, normalisation calibration, random estimation, and scatter estimation for the simulat
Clinical implications of genetic testing in familial intermediate and late-onset colorectal cancer
The genetic background of familial, late-onset colorectal cancer (CRC) (i.e., onset > age 50 years) has not been studied as thoroughly as other subgroups of familial CRC, and the proportion of families with a germline genetic predisposition to CRC remains to be defined. To define the contribution of known or suggested CRC predisposition genes to familial late-onset CRC, we analyzed 32 well-establi
Neurological pupil index and its association with other prognostic tools after cardiac arrest : A post hoc analysis
Introduction: We evaluated the concordance of the Neurological pupil Index (NPi) with other predictors of outcome after cardiac arrest (CA). Methods: Post hoc analysis of a prospective, international, multicenter study including adult CA patients. Predictors of unfavorable outcome (UO, Cerebral Performance Category of 3–5 at 3 months) included: a) worst NPi ≤ 2; b) presence of discontinuous enceph
Analysing Diet Composition and Food Insecurity by Socio-Economic Status in Secondary African Cities
This chapter takes as its starting point theorizing around nutrition and food system transitions thought to be increasingly occurring in urban Africa, and how this may be linked to a growing non-communicable disease burden. We focus specifically on the secondary city context by analysing household survey data gathered from six cities across Ghana, Kenya and Uganda during 2013–2015. We asked how di
Challenges and opportunities for increasing the use of low‑risk plant protection products in sustainable production. A review
Plant production systems worldwide are struggling to meet the diverse and increasing needs of humankind while also facing challenges such as climate change and biodiversity loss. This, combined with the desirable transition from the use of conventional pesticides to more sustainable plant protection solutions, has led to an urgent, and increasing, need for lowrisk plant protection products (PPPs)
Empirical formulation for multiple groups of primary biological ice nucleating particles from field observations over Amazonia
To resolve the various types of biological ice nuclei (IN) with atmospheric models, an extension of the empirical parameterization (EP) is proposed to predict the active IN from multiple groups of primary biological aerosol particles (PBAPs). Our approach is to utilize coincident observations of PBAP sizes, concentrations, biological composition, and ice nucleating ability. The parameterization or
Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation
Therapeutic resistance and recurrence remain core challenges in cancer therapy. How therapy resistance arises is currently not fully understood with tumors surviving via multiple alternative routes. Here, we demonstrate that a subset of cancer cells survives therapeutic stress by entering a transient state characterized by whole-genome doubling. At the onset of the polyploidization program, we ide
Many-photon effects in time-resolved second harmonic generation from systems in optical cavities
Second harmonic generation is popular due to its numerous applications in different technologies dealing with multiple fields of science. The rapid technical advancement with the second harmonic generation demands parallel development in the theoretical understanding. With this view in mind, in our three papers, we theoretically investigated second harmonic generation from different systems in an
Study protocol for a single-blind, parallel-group, randomised, controlled non-inferiority trial of 4-day intensive versus standard cognitive behavioural therapy for adults with obsessive-compulsive disorder
Introduction Individual cognitive behavioural therapy (CBT) with exposure and response prevention is an effective treatment for obsessive-compulsive disorder (OCD). However, individual CBT is costly and time-consuming, requiring weekly therapy sessions for 3-4 months. A 4-day intensive version of CBT for OCD delivered in group format has been recently developed in Norway (Bergen 4-day treatment, B
