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BACKGROUND: Knowledge is limited regarding the association between stem cells in histologically benign breast tissue and risk factors for breast cancer, and hence we addressed this issue in the present study. Recently, we assessed the histology of benign breast tissue from cancer and non-cancer patients for cells positive for the putative stem cell marker aldehyde dehydrogenase 1 A1 (ALDH), and th
The polska, under lots of different spellings and titles, was the dominant music and dance repertoire in Sweden for nearly 300 years. The main purpose of this thesis has been to clarify some of the principal characteristics in both its dance and music forms. The thesis has both a historical and an ethnomusicological perspective and moves in the intersection between different types of traditional m
Burkitt lymphoma (BL) is a rare, aggressive disorder constituting 1% of all non-Hodgkin lymphoma. Diffuse large B-cell lymphoma (DLBCL) is more common, accounting for 30% of malignant lymphoma. Standard treatment for adult BL and for certain subgroups of patients with DLBCL remains to be defined due to paucity of randomised trials performed. The focus in this thesis lies on the effect of prognosti
BACKGROUND: Parkinson's disease is typically treated with oral dopamine replacement therapies; however, long-term treatment leads to motor complications and, occasionally, impulse control disorders caused by intermittent stimulation of dopamine receptors and off-target effects, respectively. We aimed to assess the safety, tolerability, and efficacy of bilateral, intrastriatal delivery of ProSavin,
Lean premixed dry low emission (DLE) combustion system in a gas turbine engine is a globally accepted concept to reduce pollutant emissions and to improve combustion efficiency. This study is focused on an industrial downscaled prototype burner (4th Generation Dry Low Emission Burner for SGT-750 designed and manufactured by Siemens Industrial Turbo machinery AB), which has been tested extensively
Context: Extended pelvic lymph node dissection (ePLND) is the gold standard for detecting lymph node (LN) metastases in prostate cancer (PCa). The benefit of sentinel node biopsy (SNB), which is the first draining LN as assessed by imaging of locally injected tracers, remains controversial. Objective: To assess the diagnostic accuracy of SNB in PCa. Evidence acquisition: A systematic literature se
Patients with acute asthma attending the emergency room were included in a double-blind, double-dummy and parallel group study to investigate whether a dry powder inhaler (Turbuhaler) can be used in acute asthma. If so, the aim was to establish the potency relationship between a beta 2-agonist (salbutamol) administered by the dry powder inhaler and the pressurized metered-dose inhaler (pMDI). Eigh
The present doctoral thesis is a study of the problem of "variation" in relation to word stress in Russian adjectives, in both their short and long forms. The stress variation in adjectival forms is investigated from various viewpoints, the main of which is the revelation of the basic processes of stress reorganisation in these groups of words and the establishment of main tendencies of adjectival
Popular Abstract in Swedish Molekylärgenetiska och funktionella studier av BCR/ABL1 fusionsgenen: Det finns tre sorters blodkroppar, röda, vita och trombocyter, som alla bildas från gemensamma stamceller i benmärgen. När stamcellerna delar sig bildas det antingen nya stamceller eller förstadier till blodkroppar som efter ytterligare delningar blir till mogna blodkroppar. Ibland uppkommer särskildThe BCR/ABL1 fusion gene is associated with chronic myeloid leukemia and a subgroup of acute lymphoblastic leukemia. The general aim of this thesis was to increase the understanding of BCR/ABL1-induced leukemogenesis by molecular and functional studies of this fusion gene. In Article I, an experimental U937 cell line model with inducible expression of BCR/ABL1 was established and characterized. Ex
BACKGROUND: Glucose degradation products (GDPs) are cytotoxic in vitro and potentially toxic in vivo during peritoneal dialysis (PD). We are presenting the results of a two-year randomized clinical trial of a new PD fluid, produced in a two-compartment bag and designed to minimize heat-induced glucose degradation while producing a near neutral pH. The effects of the new fluid over two years of tre
The purpose of this dissertation is to study the concept of autism from a socio-legal perspective and to analyze the actual use of law in an area where knowledge rivalry is present, as in the case of autism. The ambition is to illustrate how law reacts to, and deals with, rivalry fields of knowledge within the system of decision-making. During the last decades, research on autism has been intense
Popular Abstract in Swedish De äldsta hajfossil man känner till kommer från devonperioden och är minst 380 miljoner år gamla. Under Mesozoikum (trias, jura och krita) dominerades hajfaunorna av hybodonta hajar under trias och första halvan av jura medan de moderna hajarna (Neoselachii) tog över från slutet av jura och numera är de enda levande hajarna på vår planet. Detta arbete har fokuserats påThe Jurassic and Early Cretaceous selachian faunas of Scania (Skåne), southern Sweden and the island of Bornholm (Denmark) have been investigated. Three Early Jurassic shark tooth assemblages have been recorded and investigated, one from Hettangian strata and the other two from Pliensbachian sediments. The Hettangian assemblage originates from non-marine deposits in the southern part of Helsingbor
Popular Abstract in Swedish Bakgrund I Sverige erbjuds samtliga gravida kvinnor ett rutinultraljud vid 18-20 graviditetsveckor. Syftet med undersökningen är att fastställa antalet foster, uppskatta graviditetslängd samt granska fosteranatomin för att upptäcka eventuella missbildningar. En del missbildningar kan man se med ultraljud, men långtifrån alla. Att redan under graviditeten känna till om The aim was to evaluate first trimester nuchal translucency (NT) measurement for detection and risk assessment of fetal malformations and fetal loss. 39 572 pregnant women were randomised to either a routine ultrasound scan at 12-14 weeks including NT measurement or to a routine scan at 18-20 weeks. Prenatal diagnosis of major congenital heart malformations was compared between the two groups. In
This thesis explores the changing patterns of employment and income assimilation among male immigrants to Sweden. In brief, the results of this work are that immigrants have been facing an increasingly difficult time integrating into the Swedish economy. This difficulty has not been caused by decreasing “quality” of the newer immigrant cohorts, as has often been the argument in the literature. Rat
Popular Abstract in Swedish Avhandlingen består av fem fristående uppsatser som utnyttjar tidsserieanalys för studerande av några olika makroekonomiska frågor. I kapitel två, tre och fyra används s.k. vektorautoregressiva (VAR) modeller för att studera privat konsumtionsbeteende i Sverige. Enligt den permanenta inkomst hypotesen väljer individerna sin konsumtion med hänsyn till sin långsiktiga ell
Ethical issues in modern obstetrics commonly relate to a conflict between the rights and possibilities of the fetus versus those of the mother. After delivery, when the fetus by definition is a child, all legal rights are granted to this new individual. Whether any rights should be given or offered to the fetus is dependent on the prevailing situation. General rules are difficult to give due to th
The aim of this study is to describe how ”drama in training” is experienced by student nurses and nurse tutors as well as to describe whether the students feel that there is a connection between their participation in drama, their personal development and their own preparation for their future profession. The study´s starting point has been that the students need support with regard to their perso
