Filtyp
E. coli continues to be a popular host organism for production of recombinant proteins. To obtain a high volumetric productivity at the cultivation stage, it is important to achieve a high cell density and a high specific productivity per cell. In many fed-batch processes, the substrate feed rate eventually becomes limited by the oxygen transfer capacity of the bioreactor. While biomass can contin
Popular Abstract in Swedish Katalytisk omvandling av enkla kolväten till mer användbara substanser m.h.a. homogena/lösliga komplex av övergångsmetaller är ett mycket viktigt ämnesområde inom metallorganisk kemi. För att förstå hur processen går till har ett stort antal modellföreningar syntetiserats genom åren där man har studerat hur kol-väte eller kol-kol bindningar kan brytas. Man bör notera atThe work presented in this thesis deals with metallacyclic late transition metal complexes, obtained by intramolecular Csp3-H activation, and the application of such compounds in catalysis. The new hemilabile P,O phosphines N-methyl-N-propionyl-2-(diphenylphosphino)benzylamine (DPPAM), o-(diphenylphosphino)benzoic acid ethyl ester (DPPES), o-(diphenylphosphino)benzoic acid methyl ether (DPPET) and
This thesis investigates the role of migration in international trade within the framework of behind-the-border trade barriers and firm behavior. In addition to the introduction, which provides a context to the analysis, it consists of four essays. The first essay, titled ‘Migration as Trade Facilitation? Investigating the Links Between International Trade and Migration,’ examines the cross-countr
This thesis deals with two main areas in the field of stochastic inventory theory; ateral transshipments and perishable items. In the first part of this thesis we give an introduction to the field of inventory theory, and discuss some previous literature connected to the research presented in this thesis. In the second part, the original research which defines this thesis is presented in the form
Present power system will face great challenges in several areas depending on the market economy, extensive global integration and constant need for more electric power, which will force the system to operate much closer to its stability limits. Meeting these challenges may involve improving and complementing or even total restructuring of the power systems.New technologies are emerging such as re
Introduction The hotel check-in is usually treated as a facilitating service as it is often assumed only to facilitate the use of the core service i.e. the lodging. In addition the check-in is a highly standardized process, which is repeatedly performed every day. Being only one part of the front office’s duties executed at the reception desk, it is usually given scant attention from management. L
Background: The indications for percutaneous transluminal renal angioplasty (PTRA) in renovascular disease, as well as its benefits, remain a matter of debate. The aim of this study was to evaluate the outcome of angioplasty and to identify risk factors associated with less successful outcomes in patients with atheromatous renal artery stenosis and renal failure of varying degrees. Methods: The re
Inhaled corticosteroid (ICS) therapy is central to the long-term management of asthma and is extensively used in the management of chronic obstructive pulmonary disease (COPD). While administration via inhalation limits systemic exposure compared with oral or injected corticosteroids and, therefore, the risk of systemic corticosteroid-related adverse effects, concerns over the long-term safety of
Background: The EsPhALL2004 randomised trial showed a 10% advantage in disease-free survival for short, discontinuous use of imatinib after induction compared with no use of imatinib in patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia receiving Berlin-Frankfurt-Münster chemotherapy and haemopoietic stem-cell transplantation (HSCT). Other contemporary studies showed an a
Importance: Prenatal exposure to phthalates has been associated with neurodevelopmental outcomes, but little is known about the association with language development. Objective: To examine the association of prenatal phthalate exposure with language development in children in 2 population-based pregnancy cohort studies. Design, Setting, and Participants: Data for this study were obtained from the
BackgroundWorldwide, an estimated 5 billion people lack access to safe, affordable surgical care when needed. This leads to millions of avertable deaths and unnecessary morbidity each year. To change this situation, urgent action is needed at many levels, but indicators and data have been lacking to guide improvement.AimsThe aim of this thesis was to describe and evaluate measurement of surgical p
BACKGROUND: Before this study started, the standard postoperative chemotherapy regimen for stage II-III Wilms' tumour pretreated with chemotherapy was to include doxorubicin. However, avoidance of doxorubicin-related cardiotoxicity effects is important to improve long-term outcomes for childhood cancers that have excellent prognosis. We aimed to assess whether doxorubicin can be omitted safely fro
To improve the properties and functionality of starch, it is important to understand the physicochemical and structural characteristics as raw material, after being modified to increase its characteristics and/or during changes due to the processing conditions. For this reason, the objective of the present thesis is to improve the understanding of characteristics and molecular properties like mola
Importance: Accurate blood-based biomarkers for Alzheimer disease (AD) might improve the diagnostic accuracy in primary care, referrals to memory clinics, and screenings for AD trials. Objective: To examine the accuracy of plasma β-amyloid (Aβ) and tau measured using fully automated assays together with other blood-based biomarkers to detect cerebral Aβ. Design, Setting, and Participants: Two pros
1. The effects and binding characteristics of a series of chimeric galanin-neuropeptide Y (NPY) peptides were examined in various preparations known to contain a predominant population of either Y1 or Y2 receptors for NPY or galanin receptors. 2. NPY suppressed the electrically stimulated twitches of the rat vas deferens (Y2 receptors), while galanin enhanced the electrically stimulated twitches.
Geotechnical engineering is the science dealing with mechanics of soils and rocks and its engineering applications. Geotechnical engineering projects vary in a wide range, from evaluation of the stability of natural slopes and man-made soil deposits, to the design of earthworks and foundations. Traditional methods, using manual calculations or simplified computational methods, do not, as a rule, t
BACKGROUND: Factor affecting sperm retrieval rate (SRR) or pregnancy rates (PR) after testicular sperm extraction (TESE) in patients with non-obstructive azoospermia (NOA) have not been systematically evaluated. In addition, although micro-TESE (mTESE) has been advocated as the gold standard for sperm retrieval in men with NOA, its superiority over conventional TESE (cTESE) remains conflicting. OB
