Filtyp
The quinoline-3-carboxamides (Q compounds) are a family of small molecules with immunomodulatory functions that have shown efficacy in various murine models of inflammatory diseases. One such compound has demonstrated antitumor effects in murine models. Q compounds bind to S100A9, thereby preventing its ligation to TLR4 and RAGE. S100A9 is a small molecule which has shown to have a role in the est
Telomeres are the conservative sequence repeats located at the end of linear chromosomes that have been the focus of intensive research across many disciplines over the last four decades. They function as a cap to protect the chromosome ends from fusion to other chromosomes and to prevent chromosome degradation. Telomere shortening is thought to be involved in ageing, reflecting or even causing ag
Too Many Doing Too Little On Contemporary European Film Production Cultures In a majority of Western European countries, the two concurrent, post-World War II tendencies of increasing economic difficulties for the national film industries and the developing recognition of film as a significant contemporary art form were imperative for the introduction of film support. With Hollywood dominating sc
Popular Abstract in Swedish I Sverige är intaget av kostfiber lågt. Endast 5‒20% av alla vuxna uppnår det rekommenderade dagliga intaget. Fiberrika livsmedel bör utgöra en stor del av en hälsosam diet eftersom man har visat att det finns ett samband mellan högt fiberintag och minskad risk för välfärdssjukdomar såsom hjärt-kärl sjukdomar och typ 2 diabetes. Kostfibrer kan till exempel sänka ditt onThe spread of lifestyle-related diseases has become epidemic throughout the world. Impaired glucose metabolism and high levels of plasma cholesterol are risk factors for the development of type 2 diabetes and cardiovascular disease respectively. Soluble dietary fibers from plants, algae and mushrooms have been shown to positively regulate both glucose- and cholesterol metabolism indicating their v
Popular Abstract in Swedish En vän till mig berättade hur hon hade köpt en färgglad t-shirt vid en resa till Indien. Första gången hon hade den på sig började det att ösregna och ett par minuter senare fanns det snopet nog mer färg i de kringliggande vattenpölarna än i tyget. Lyckligtvis har de flesta färger idag bättre kvalitet än så. De färger som används inom textilindustrin är utvecklade för aConsiderable amounts of water and chemicals are used in the textile industry, and the presence of dyes in the wastewater is a problem of environmental concern. Synthetic dyes are designed to resist light, water and chemicals to improve the quality of the textiles; however, these properties also contribute to their persistence in the environment. The existence of wastewater treatment plants in conn
Accumulating evidence suggests that the main human cathelicidin peptide, LL-37, may influence host cell viability and pro-inflammatory signaling when locally overexpressed. LL-37 has pro-inflammatory properties linked to the development of for example psoriasis, rosacea, SLE and atherosclerosis. However, the importance of LL-37-induced host cell permeabilization and cytotoxic effects are poorly un
Blood group antigens may be used as receptors by pathogens when infecting their hosts. Different blood groups therefore can be disease susceptibility factors. Thus, pathogens may have exerted a selection pressure on the evolution of blood group diversity. One aim of our study was to identify red blood cell (RBC) membrane structures that are bound by the common human pathogen. Streptococcus pyogene
STUDY QUESTION Is male factor infertility associated with an increased risk of developing diabetes? SUMMARY ANSWER The study provides evidence that male factor infertility may predict later occurrence of diabetes mellitus with the risk being related to the severity of the underlying fertility problem. WHAT IS KNOWN ALREADY Previous cross-sectional studies have shown an increased prevalence of como
Doctoral education in medicine, engineering, technology and science (METS) is in many ways different from doctoral education in the humanities or social sciences. In the METS disciplines, typically, students and supervisors work and publish together within the supervisors’ research projects. The projects are usually financed by the supervisors’ research grants and their success, in terms of high q
IMPORTANCE The clinical management of BRCA1 and BRCA2 mutation carriers requires accurate, prospective cancer risk estimates. OBJECTIVES To estimate age-specific risks of breast, ovarian, and contralateral breast cancer for mutation carriers and to evaluate risk modification by family cancer history and mutation location. DESIGN, SETTING, AND PARTICIPANTS Prospective cohort study of 6036 BRCA1 and
Institutioner har betydelse för ekonomisk utveckling. Denna avhandling består av tre fristående artiklar som bidrar till olika grenar inom institutionell ekonomi.I den första artikeln undersöks kortsiktiga förändringar av könsnormer. Artikeln tar tillvara på senare tids utveckling av maskininlärningsalgoritmer för att studera normförändringar i svenska tweets. Mer specifikt så tränas en LSTM neuraInstitutions matter for economic development. This thesis consists of three self-contained articles which provide different contributions to institutional economics.The first article studies short-run changes in gender norms. It takes advantage of recent developments in machine learning algorithms to study changes in norms in Swedish tweets. More specifically, gender norms are defined in a compreh
Lexical frequency effects on word accent processing in SwedishSeveral studies have investigated the neurophysiological underpinnings of the Swedish word accents, “accent 1” and “accent 2” ([1]-[5]), which are known to have a strong association with morphology ([6]-[8]). For example, if the singular noun suffix -en is attached to the word stem bil (‘car’), the resulting word is bil1-en (‘the car’)
Concrete is the most common material used to build the structural framework in multistory buildings. However, the construction works carried out on the building site are affected by many different factors that may reduce productivity. Delayed material deliveries, poor planning and coordination of work tasks and production resources, as well as unfavorable weather are examples that reduce productiv
Importance: Local steroid injection is commonly used in treating patients with idiopathic carpal tunnel syndrome, but evidence regarding long-term efficacy is lacking. Objective: To assess the long-term treatment effects of local steroid injection for carpal tunnel syndrome. Design, Setting, and Participants: This exploratory 5-year extended follow-up of a double-blind, placebo-controlled randomiz
Background: Tyrosine kinase inhibitors (TKIs) have improved the survival of patients with chronic myeloid leukaemia. Many patients have deep molecular responses, a prerequisite for TKI therapy discontinuation. We aimed to define precise conditions for stopping treatment. Methods: In this prospective, non-randomised trial, we enrolled patients with chronic myeloid leukaemia at 61 European centres i
The health among men and women with same-sex sexuality experience, i.e. attraction to and/or sexual relations with someone of the same sex, in Sub-Saharan Africa is an increasing public health concern. Prior research on men who have sex with men (MSM) has demonstrated that their healthcare utilisation is limited due to stigma and discrimination. However, little is known about the extent to which t
AbstractInorganic arsenic exposure through drinking water is a serious public health concern because of its association to cancer and non-cancer diseases. More than one hundred million people world-wide are exposed to elevated levels of arsenic on a regular basis. Arsenic is classified as class I carcinogen by International Agency for Research on Cancer (IARC). Recent report shows that arsenic exp
