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Biomimetic Macroporous Hydrogels: Protein Ligand Distribution and Cell Response to the Ligand Architecture in the Scaffold

Macroporous hydrogels (MHs), cryogels, are a new type of biomaterials for tissue engineering that can be produced from any natural or synthetic polymer that forms a gel. Synthetic MHs are rendered bioactive by surface or bulk modifications with extracellular matrix components. In this study, cell response to the architecture of protein ligands, bovine type-I collagen (CG) and human fibrinogen (Fg)

Dry deposition of reactive nitrogen to European ecosystems: a comparison of inferential models across the NitroEurope network

Inferential models have long been used to determine pollutant dry deposition to ecosystems from measurements of air concentrations and as part of national and regional atmospheric chemistry and transport models, and yet models still suffer very large uncertainties. An inferential network of 55 sites throughout Europe for atmospheric reactive nitrogen (N-r) was established in 2007, providing ambien

Differences in prevalence and treatment of Pseudomonas aeruginosa in cystic fibrosis centres in Denmark, Norway and Sweden

Background: Chronic Pseudomonas aeruginosa (PA) infection causes increased morbidity and mortality in cystic fibrosis (CF). This study aimed to answer the following questions: Does the prevalence of chronic infection with PA differ between the CF centres in Scandinavia? Which differences exist concerning segregation and treatment of PA? Methods: 989 patients (86%) from all eight CF-centres in Scan

Long-term infusion of nutrients (total parenteral nutrition) suppresses circulating ghrelin in food-deprived rats.

Background: Ghrelin derives from endocrine cells (A-like cells) in the stomach (mainly the oxyntic mucosa). Its concentration in the circulation increases during fasting and decreases upon re-feeding. This has fostered the notion that the absence of food in the upper gastrointestinal (GI) tract stimulates the secretion of ghrelin. The purpose of the present study was to determine the concentration

Supporting Decisions on Regression test Scoping in a Software Product Line Context - from Evidence to Practice

Large software organizations with a product line development approach face many challenges regarding testing. Test managers need to make tradeoffs along three dimensions of repeated testing (abstraction level, time and product space) and consider a range of goals and constraints. In order to keep pace with the decreased development time for new products, which is enabled by the systematic reuse, s

Nonoperatively treated burst fractures of the thoracic and lumbar spine in adults: a 23-to 41-year follow-up

BACKGROUND CONTEXT: Several studies report a favorable short-term outcome after nonoperatively treated two-column thoracic or lumbar burst fractures in patients without neurological deficits. Few reports have described the long-term clinical and radiological outcome after these fractures, and none have, to our knowledge, specifically evaluated the long-term outcome of the discs adjacent to the fra

A preanalytic validation study of automated bone scan index : Effect on accuracy and reproducibility due to the procedural variabilities in bone scan image acquisition

The effect of the procedural variability in image acquisition on the quantitative assessment of bone scan is unknown. Here, we have developed and performed preanalytical studies to assess the impact of the variability in scanning speed and in vendor-specific γ-camera on reproducibility and accuracy of the automated bone scan index (BSI). Methods: Two separate preanalytical studies were performed:

Mentally disordered offenders in Sweden : differentiating recidivists fromnon-recidivists in a 10-year follow-up study

Background: Forensic psychiatric patients present a challenge as they manifest severe mental disorders together with criminal behaviour. There are well-known risk factors for criminal behaviour in the general population, yet knowledge of what predicts reconviction in the Swedish forensic population in the long-term perspective is still insufficient. Aims: The study aims to (1) describe background

Formation and Early Evolution of Planetary Systems

Planeter är mycket vanliga i vår galax. De senaste 20 åren har man upptäckt att de flesta solliknande stjärnor har planeter kretsande omkring sig. Man vet också att det finns en stor variation av exoplaneter. Runt 50\% av alla solliknande stjärnor har superjordar (planeter med en massa eller radie mellan jordens och Neptunus) kretsande tätt intill sig vilket gör solsystemet otypiskt. Man har hittaOver the past 20 years we have discovered that exoplanets are common in the Galaxy, and are far more diverse than anyone expected. Half of all Sun-like stars are accompanied by at least one super-Earth (a planet with a size between Earth and Neptune), many planets have very high eccentricities indicative of a dynamical origin, and a small fraction of stars are accompanied by hot Jupiters, whose or

Getting the picture of home lighting: Adding participant photography to the interview

This paper draws attention to the potential benefits of using photographs in combination with interviews, that is to say photo elicitation. As defined by Harper (2002), photo elicitation is “based on the simple idea of inserting a photograph into a research interview” (p. 13). The photographs can be taken by the researcher or the participant to evoke comments. If participants are asked to produce

Impact of Human Papillomavirus (HPV)-6/11/16/18 Vaccine on All HPV-Associated Genital Diseases in Young Women.

Background The impact of the prophylactic vaccine against human papillomavirus (HPV) types 6, 11, 16, and 18 (HPV6/11/16/18) on all HPV-associated genital disease was investigated in a population that approximates sexually naive women in that they were "negative to 14 HPV types" and in a mixed population of HPV-exposed and -unexposed women (intention-to-treat group). Methods This analysis studied

Electrophysiological evaluation and visual outcome in patients with central retinal vein occlusion, primary open-angle glaucoma and neovascular glaucoma.

Purpose: To evaluate patients with central retinal vein occlusion (CRVO) and neovascular glaucoma (NVG) using electrophysiology in order to gain better understanding of visual outcome and risk factors, such as previously diagnosed primary open-angle glaucoma (POAG). Methods: Eighty-three patients (83 eyes) initially presenting with CRVO and examined with full-field electroretinography (ERG) within

Assessment of conventional cardiovascular risk factors and multiple biomarkers for the prediction of incident heart failure and atrial fibrillation.

OBJECTIVES: the purpose of this study was to assess the predictive accuracy of conventional cardiovascular risk factors for incident heart failure and atrial fibrillation, and the added benefit of multiple biomarkers reflecting diverse pathophysiological pathways. BACKGROUND: heart failure and atrial fibrillation are interrelated cardiac diseases associated with substantial morbidity and mortality

Estimation of Thermal and Hydraulic Characteristics of Compact Brazed Plate Heat Exchangers

Popular Abstract in Swedish Lödda kompakta plattvärmeväxlare används i stor utsträckning i kyl – och värmepumpanläggningar samt luftkonditioneringsanläggningar. Såväl enfasvärmeutbyte, dvs värmeutbyte mellan två vätskor, som fasomvandling genom kondensation och förångning är viktiga tillämpningsområden. Apparaterna användes inom industri, hushåll, samhälleliga inrättningar mm. Prestandan för olikaThis thesis work presents various performance estimation methods of compact brazed plate heat exchangers (BPHE) operating in single phase, condenser, evaporator, cascaded and transcritical applications. Such methods play a vital role in development of heat exchanger selection software and during geometry parameter estimation in the new product development process. The suitability of employing comm

Rätt säker brottsbekämpning eller rättssäker brottsbekämpning? – En systemteoretisk granskning av avvägningen mellan effektiv brottsbekämpning och materiell rättssäkerhet utifrån den tilltalades centrala rättigheter.

I samhällsdebatten har åsikter om en mer effektiv brottsbekämpning växt fram på den senaste tiden. Debatten har utmynnat i flertalet offentliga utredningar som presenterar potentiella lagändringar. Förslagen innebär att en avvägning måste göras mellan effektiv brottsbekämpning och rättssäkerhet, eftersom dessa medför en stor risk att individens rättigheter inskränks. Syftet med uppsatsen är att bIn the public debate, opinions about more effective law enforcement have emerged in recent years. The debate has resulted in public investigations that present potential changes to the law. The proposals imply that a balance must be struck between effective law enforcement and the rule of law, as the proposals entails a great risk for the rights of the individual to be restricted. The purpose of

Background Studies of the High-Intensity Baryon Extraction and Measurement (HIBEAM) Experiment at the European Spallation Source

The High-Intensity Baryon Extraction and Measurement experiment (HIBEAM) is proposed as one of the experimental stations at the European Spallation Source (ESS). This experiment will mainly focus on the neutron into sterile neutron oscillations which violate the baryon number (B) by one unit. The sterile neutrons are hypothetical dark matter candidates. The neutrons suitable for the experiment hav

A Concept for an Intrusion Detection System over Automotive Ethernet

A modern automotive vehicle is a complex technical system, containing many electronic, mechanical, and software parts. Typically, a high-end vehicle contains 70 or more electronic control units (ECUs) on average. These are controlling a large number of distributed functions, of which many are safety-critical, and adding complexity, which is surpassing 100 million lines of code. Furthermore, the co

Stilsättning av geografiska data

Geografiska data är all data som är knutna till ett geografiskt läge och används inom många olika områden i samhället såsom all form av samhällsbyggnad och samhällsplanering, klimat och miljö, kultur och natur, krishantering samt transporter och logistik. För att geografiska data ska kunna användas över läns- och kommungränser samt i olika organisationer krävs ett enhetligt system och standarder fGeographic data are data that is linked to a geographic location and is used in many different areas of society, such as all types of community and community planning, climate and environment, culture and nature, crisis management, transport and logistics. In order for geographic data to be used across county and municipal boundaries as well as in different organisations, a uniform system and stan

Decision-making of employees in tech-driven R&D: An exploratory study on effectuation theory within the Fuzzy Front End of Innovation.

Problem - Uncertainty greatly burdens innovation in tech-driven industries which has made decision-making an art-like navigation, especially within the Fuzzy Front End of operations. This has motivated previous researchers to study the effectual decision-making principles originated by Sarasvathy in regard to a wide variety of audiences such as entrepreneurs, start-ups and top management. Employee