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Background: In Alzheimer’s disease (AD), the associations between tau pathology and brain atrophy and cognitive decline are well established, but imperfect. We investigate whether cerebrospinal fluid (CSF) biomarkers of biological processes (vascular, synaptic, and axonal integrity, neuroinflammation, neurotrophic factors) explain the disconnection between tau pathology and brain atrophy (brain re
Time-of-flight mass-spectrometry (TOF-MS) measurements of 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ([EMIM][OTF]) vapors have been conducted in order to gain insight into the VUV (vacuum ultraviolet) absorption thresholds. The experimental data were interpreted with hybrid density-functional theory (DFT), time-dependent DFT (TD-DFT), and several flavours of many-body perturbation theor
BACKGROUND: The use of nitrous oxide (N2O) during hemodilution has been questioned. Nitrous oxide reduces the inspired oxygen fraction (F1O2), depresses myocardial function and may reduce cardiac output (CO) and systemic oxygen delivery (DO2SY). The aim of this study was to evaluate the importance of the effects of nitrous oxide on systemic and myocardial circulation and oxygenation during extreme
Cross-sectional studies have associated obesity and other components of the so-called metabolic syndrome with low-grade inflammation. The temporal and causal relations of this association have not been fully explored. This study explored whether elevated levels of inflammation-sensitive plasma proteins (ISPs) (fibrinogen, orosomucoid, {alpha}1-antitrypsin, haptoglobin, and ceruloplasmin) are assoc
The inclusive e(+)p single and double differential cross sections for neutral and charged current processes axe measured with the H1 detector at HERA. The data were taken in 1999 and 2000 at a centre-of-mass energy of roots = 319 GeV and correspond to an integrated luminosity of 65.2 pb(-1). The cross sections are measured in the range of four-momentum transfer squared Q(2) between 100 and 30 000
Background: Thrombolysis is a common method in the treatment of lower extremity bypass graft occlusion. The purpose of this study was to investigate the results of thrombolytic therapy in the management of acute bypass graft occlusion and to identify risk factors for technical failure and amputation. Methods: All patients at two tertiary referral centers undergoing thrombolysis for acute graft occ
The presented thesis work is concerned with the study of molecular dynamics using liquid nuclear magnetic resonance (NMR) spectroscopy. Spin relaxation dispersion experiments in the rotating frame (R1ρ) are employed to provide a detailed, atomic-resolution view of protein dynamics. Comprehensive investigations of 15N backbone and 13C methyl side-chain confor
This study explores the meaning of the two expressions 'times of refreshing' and 'time to restore everything' in Acts 3:19.21. These two eschatological motifs appear in a speech that the apostle Peter made, according to Luke's presentation, in the Jerusalem temple in the beginning of the 30s. The study is historical, and the meaning of the two expressions is sought in the contemporary world. It i
Popular Abstract in Swedish Denna avhandling handlar om utveckling och tillämpning av metoder för jonstråleanalys av lätta ämnen (lättare än ungefär aluminium), framförallt vid en nukleär mikrosond. Vid en nukleär mikrosond accelereras tunga partiklar, t.ex. protoner, av en partikelaccelerator och fokuseras av ett speciellt magnetiskt linssystem ned till en storlek av ungefär 1 mikrometer. Denna sThis thesis treats the development of Ion Beam Analysis (IBA) methods, principally for the analysis of light elements at a nuclear microprobe (NMP). The light elements are in this context defined as those with an atomic number Z of less than approximately 13 (aluminium). The work reported is to a large extent based upon multiparameter methods. Several signals are acquired simultaneously, and the d
Popular Abstract in Swedish De flesta produkter som vi dagligen använder tillverkas genom att utnyttja fossila råvaror som olja, kol och naturgas. Ett stort problem är att dessa råvaror bara finns i begränsade mängder i naturen, vilket medför att de förr eller senare tar slut. Dessutom medför förbränning av fossila råvaror att det bildas miljöskadande gaser (t.ex. koldioxid) som ansamlas i atmosfäOne of the major challenges facing the world today is the reduction of our dependency on fossil resources as their exploitation has severe negative effects on the environment. One way of realizing this is to utilise the components of lignocellulosic biomass to a greater extent as feedstock for various industrial products. However, such utilisation requires the extraction of the biopolymers from th
Popular Abstract in Swedish Levande organismer, inklusive människor, har en 14C/12C-kvot som återspeglar miljön. När materialet dör slutar kroppen att fylla på 14C och kroppens 14C börjar sönderfalla till 14N. Detta gav upphov till den klassiska 14C-dateringsmetoden, vilken utvecklades av professor W.F. Libby, 1949 och gav honom Nobelpriset i kemi 1960. 14C-datering används huvudsakligen inom arkeThe testing of nuclear weapons in the atmosphere, in the middle of the 20'h century, resulted in a bomb-pulse excess of atmospheric 14C. A bomb-pulse dating method was thus developed. The latter is a method to determine the time of formation of formerly living modern (i.e. living after 1955) material , based on the 14C/ 12C ratio in it. The objective of this work was to evaluate the factors that c
Popular Abstract in Swedish Transporter är viktiga för ett fungerande samhälle, men samtidigt innehåller avgaserna från en förbränningsmotor farliga utsläpp som förorenar vår miljö. Kan vi på något sätt hindra att miljön blir förstörd av farliga utsläpp genom förbättrad motordesign? Frågan om global uppvärmning har varit vid liv enda sedan IPCC (Intergovernmental Panel on Climate Change) grundadeThis thesis concerns a numerical investigation on heat transfer in internal combustion engines, with the aim of increasing engine efficiency. The efficiency gains are to be extracted from reduced heat transfer losses, by increasing the knowledge on how the heat transfer process is affected by various hardware and operational parameters in the engine. The engines concerned are both conventional die
Laser Doppler velocimetry (LDV) measurement and large eddy simulation (LES) were used to study confined isothermal turbulent swirling flows in a model dump combustor. The aim was to gain deeper understanding of the flow and turbulence structures in dump combustors and to examine the capability of LES for prediction of turbulent swirling flows. A refractive index matching technique is used in the L
Five acute leukaemia or highly malignant lymphoma patients at a hospital in southern Sweden were interviewed about their daily living problems, their coping strategies and their opinions about the nursing care they received during the active phase of their treatment. In addition the EORTC QLQ-C30, the Global Life Quality and the Sense of Coherence scales were administered. The data were analysed f
An early and accurate diagnosis of Alzheimer's disease (AD) is required to initiate symptomatic treatment with currently approved drugs and will be of even greater importance if disease modifying compounds in development display a clinical effect. Protein profiles of human cerebrospinal fluid samples from AD patients (n = 95) and population-based healthy controls (n = 72) were analyzed by SELDI-TO
Purpose: To determine progression factors at the end of the Early Manifest Glaucoma Trial (EMGT) based on all EMGT patients and evaluate separately patients with higher and lower baseline intraocular pressure (IOP; median split). Design: Cohort of clinical trial participants. Participants: Patients with early open-angle glaucoma randomized to argon laser trabeculoplasty plus betaxolol (n = 129) or
Background There is currently no standardized process for long-term follow-up care. As a result, management of post-stroke care varies greatly, and the needs of stroke survivors are not fully addressed. The Post Stroke Checklist was developed by the Global Stroke Community Advisory Panel as a means of standardizing long-term stroke care. Since its development, the Post Stroke Checklist has gained
Problem: Undersöker hur läkemedelsförpackningar interagerar med patienter i deras vardag och beskriver patienters behov på läkemedelsförpackningar. Syfte: Fördjupa mig i vilka användarbehov det finns på läkemedelsförpackningar ur patientens perspektiv. Och därigenom ökar medvetenheten och förståelsen av patientens behov på läkemedelsförpackningar och därigenom förhoppningsvis leda till förbättradProblem discussion: Examine how pharmaceutical packaging interact with patients in their everyday lives and describe patients’ needs off pharmaceutical packaging. Purpose: Immerse myself in what user needs are on pharmaceutical packaging from the patient's perspective. Thereby increasing awareness and understanding of patient needs in pharmaceutical packaging and thereby hopefully lead to imp
