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In this paper we conduct a multi-criteria analysis (MCA) from a multiple stakeholder point of view for the design of access and benefit sharing (ABS) agreements concerning genetic resources, in particular regarding the access component of such agreements. We start by analyzing the objectives defined by international law (viz. the Convention on Biodiversity and the Nagoya Protocol) that every party
Diamond-Blackfan anemia (DBA) is a rare genetic disorder in which patients present a scarcity of erythroid precursors in an otherwise normocellular bone marrow. Most, but not all, patients carry mutations in ribosomal proteins such as RPS19, suggesting that compromised mRNA translation and ribosomal stress are pathogenic mechanisms causing depletion of erythroid precursors. To gain further insight
While research in the field of technology is surging, research on older adults playing an active role in designing and developing smart home technology (SHT) to enhance usability and adoption is lacking. It is important to co-develop products with potential users to better match their needs and desires. This study aims to generate ideas about SHT that can enhance the use and adoption of SHT that c
The maker movement has reached the optics labs, empowering researchers to create and modify microscope designs and imaging accessories. 3D printing has a disruptive impact on the field, improving accessibility to fabrication technologies in additive manufacturing. This approach is particularly useful for rapid, low-cost prototyping, allowing unprecedented levels of productivity and accessibility.
Green care is a new business venture that seeks to sell nature-based services for social and therapeutic purposes. In recent years, political, scientific and professional interest in green care has been growing in Sweden. Green care practitioners have begun the process of drawing closer links between agriculture and healthcare in an effort to encourage multi-sectorial thinking by allowing private
Despite advances in understanding the mechanisms, risk factors and treatment strategies for Alzheimer’s disease (AD), no approved therapies exist to prevent or delay onset in at-risk individuals or those with elevated biomarkers who do not yet show symptoms. Multiple candidate interventions are now being evaluated in clinical trials in these settings, raising key questions around which populations
Firefighters can be occupationally exposed to a wide range of airborne pollutants during fire-extinguishing operations. The overall study aim was to characterize occupational exposure to smoke for several groups of workers responding to fires, with specific aims to determine the correlations between exposure markers and to biologically assess their systemic exposure to polycyclic aromatic hydrocar
Modeling metalloproteins often requires classical molecular dynamics (MD) simulations in order to capture their relevant motions, which in turn necessitates reliable descriptions of the metal centers involved. One of the most successful approaches to date is provided by the "cationic dummy model", where the positive charge of the metal ion is transferred toward dummy particles that are bonded to t
Therapies derived from substances of human origin (SoHOs) such as organs, cells, and tissues provide life-saving or life-changing treatment for millions of people worldwide each year. However, many people lack timely access to SoHO-based therapies because of insufficient supplies of these exceptional health resources and/or broader barriers in access to healthcare. Despite well-established governm
Background: Management of young febrile infants is challenging. Therefore, several guidelines have been developed over the last decades. However, knowledge regarding the impact of introducing guidelines for febrile infants is limited. We assessed the impact of and adherence to a novel guideline for managing febrile infants aged ≤59 days. Methods: This retrospective cross-sectional study was conduc
This paper aims to study how firms must be agile to overcome risks and manage cost repercussions. Specifically, it focuses on promoting digitalization in Indian food SMEs for greater competitiveness. The main purpose is to design a model for implementing robust interventions in a rational manner. To achieve this, a mixed approach, including a literature review and the Decision-Making Trial and Eva
There is a lack of studies aiming to assess cellular a disintegrin and metalloproteinase-17 (ADAM-17) activity in COVID-19 patients and the eventual associations with the shedding of membrane-bound angiotensin-converting enzyme 2 (mACE2). In addition, studies that investigate the relationship between ACE2 and ADAM-17 gene expressions in organs infected by SARS-CoV-2 are lacking. We used data from
This paper introduces the comprehensive web-based IWG5 tool to evaluate energy consumption, renovation costs, and environmental impacts for European residential and office building renovations. Developed to support the SET-Plan Implementation Working Group 5 on Energy Efficiency in Buildings, the tool establishes benchmarks across five European climate zones by integrating dynamic building perform
In this evaluation of the international legal standing of the right to reparation and its practical implementation at the national level, Christine Evans outlines State responsibility and examines the jurisprudence of the International Court of Justice, the Articles on State Responsibility of the International Law Commission and the convergence of norms in different branches of international law,
Urbanisation, digitalisation and emerging technologies are reshaping young people’s relationship with the outdoor environment. We investigate how everyday outdoor experiences and spaces support adolescent wellbeing, understood as both feeling good and functioning well. Adolescents, at a pivotal stage in life, are particularly sensitive to environmental factors that influence their wellbeing. We co
Horizontal gene transfer by conjugative plasmids plays a critical role in the evolution of antibiotic resistance. Interactions between bacteria and other organisms can affect the persistence and spread of conjugative plasmids. Here we show that protozoan predation increased the persistence and spread of the antibiotic resistance plasmid RP4 in populations of the opportunist bacterial pathogen Serr
