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Human neural stem cells: region-specific properties and prospects for cell therapy

Popular Abstract in Swedish Stroke är en sjukdom som främst drabbar äldre och är den största anledningen till att människor får olika slags handikapp såsom förlamning och afasi. Det finns ännu ingen effektiv behandling för att lindra symtom och lidande efter en stroke, förutom rehabilitering, och därför kostar stroke samhället enormt mycket pengar. Befolkningen blir allt äldre, vilket även medför Cell replacement by neural transplantation can, in animal models of neurodegenerative diseases, reconstruct damaged brain circuitry. In the clinical situation, the graft material used for cell therapy must, most likely, be of human origin. The human fetal brain is one potential source of neural stem cells (NSCs) for cell replacement therapy in neurodegenerative disorders such as stroke. Stroke is

Ansvarsfördelningen mellan Riksbanken och Finansinspektionen avseende finansiell stabilitet

Det finansiella systemet spelar en central roll i ekonomin. Särskilt banker innehar en viktig roll i allokeringen av finansiella resurser och intar en central position i betalningsmekanismen för hushåll, företag och myndigheter. Störningar i enskilda finansiella institut kan snabbt spridas till övriga institut och till det finansiella systemet som helhet. En krissituation kan snabbt radera förtroeThe financial system plays a central role in the economy. In particular banks play a key role in the allocation of financial resources and occupies a central position in the payment mechanism for households, businesses and governments. Disruptions in individual financial institutions can quickly spread to other institutions and to the financial system as a whole. A crisis can further quickly erase

The molecular basis of thrombolysis and its clinical application in stroke

The rationale for thrombolysis, the most promising pharmacological approach in acute ischaemic stroke, is centred on the principal cause of most ischaemic strokes: the thrombus that occludes the cerebral artery, and renders part of the brain ischaemic. The occluding thrombus is bound together within fibrin. Fibrinolysis acts by activation of plasminogen to plasmin; plasmin splits fibrinogen and fi

Nutrient concentrations in stumps and coarse roots of Norway spruce, Scots pine and silver birch in Sweden, Finland and Denmark

The objective of this study was to evaluate the concentrations of nutrients in stumps and coarse roots in Norway spruce, Scots pine and silver birch in Sweden, Finland and Denmark, and to assess how nutrient concentrations vary with site characteristics, stand age and root size. Concentrations of nitrogen (N), phosphorus (P), potassium (K), calcium (Ca), magnesium (Mg) and sodium (Na) in spruce, p

EUCAARI ion spectrometer measurements at 12 European sites - analysis of new particle formation events

We present comprehensive results on continuous atmospheric cluster and particle measurements in the size range similar to 1-42 nm within the European Integrated project on Aerosol Cloud Climate and Air Quality interactions (EUCAARI) project. We focused on characterizing the spatial and temporal variation of new particle formation events and relevant particle formation parameters across Europe. Dif

Juxtaposed narrative : The dilemma of cultural memory on display in George Town’s street art

Street art is a ubiquitous visual landmark in contemporary George Town, the capital city of Penang state in Malaysia. Both private commissioned and state-sanctioned types of street art are the new significant cultural identification of this World Heritage Site city as inscribed by UNESCO in 2008. Street art in this multicultural city becomes the articulated media that deals with the notion of cult

Modesty as a Condition for Circular Economy Transition Success

Modesty as a Condition for Circular Economy Transition SuccessThe Promise and Challenges of a Circular Economy TransitionThe circular economy offers much promise. Circularity is meant to be a pathway to material efficiency, energy transitions, green jobs, profitable business opportunities, reduced volatility in price of inputs, secured supplies of critical materials, increased customer experiences

Biomass, community structure and phosphorus uptake of ectomycorrhizal fungi in response to phosphorus limitation and nitrogen deposition

High levels of nitrogen (N) deposition might result in a transition from N to phosphorus (P) limitation in high latitude forests. Thiscould have fundamental consequences for forest production, nutrient acquisition and nutrient leaching.I studied a Norway spruce forest in a region of high N deposition in southwest Sweden and added N, P or N+P to force thesystem to N or P limitation. I studied tree

Human cancer, the naked mole rat and faunal turnovers

We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade-off between offspring variability and cancer resistance, and thus favored cancer-prone individuals. We turn the attention to a factor setting the highly cancer-resistant naked mole rat apart from most other mammals: it has remained phenotypically largely unch

Comparative evaluation of 3D pose estimation of industrial objects in RGB pointclouds

3D pose estimation is a crucial element for enabling robots to work in industrial environment to perform tasks like bin-picking or depalletizing. Even though there exist various pose estimation algorithms, they usually deal with common daily objects applied in lab environments. However, coping with real-world industrial objects is a much harder challenge for most pose estimation techniques due to

Fire and Rescue Service Preparedness : Current Planning for Natural Hazards and the Role of Early Detection

Despite various ongoing international initiatives, the intensity and frequency of weather-related natural hazards is expected to continue to increase globally. Increasing our understanding of how to mitigate the consequences of such natural hazards through better detection, planning and preparedness, has constituted the overarching objective of this thesis. The thesis is based on three papers: PapDespite various ongoing international initiatives, the intensity and frequency of weather-related natural hazards is expected to continue to increase globally. Increasing our understanding of how to mitigate the consequences of such natural hazards through better detection, planning and preparedness, has constituted the overarching objective of this thesis. The thesis is based on three papers: Pap

Interimistiskt förbud och informationsföreläggande - En komparativ studie mellan den enhetliga patentdomstolens bestämmelser och svensk rätt

The unified patent court is currently one of the most intensely discussed areas in patent law. The Court will in essence have exclusive jurisdiction to hear disputes concerning European patents. In intellectual property law the possibility of interim measures such as interlocutory injunctions are of great importance, not the least in patent law. In Sweden, interlocutory injunctions and legal prov

Efficient Barrier Option Greeks using Automatic Differentation

K¨anslighetsanalys av barri¨aroptioner med algoritmisk derivering F¨or att f˚a ut optionspris och derivator p˚a priset med avseende p˚a tex r¨anta och volatilitet, utf¨ors vanligtvis ett antal simuleringar varp˚a ett medelv¨arde r¨aknas ut. D¨arefter r¨aknas derivatorna ut med en finit differensmetod. F¨or att erh˚alla tillf¨orlitliga resultat med denna metod kr¨avs ett stort antal simuleringar viAutomatic Differentiation (AD) is an effective method for calculation of derivatives. It can evaluate an unlimited number of derivatives to a fixed cost relative to the computing time of the original function. The AD technique is used in many fields for large and complex calculations in order to get accurate values of derivatives fast. Banks and other financial institutions handle calculations of

Deep Learning to Predict Hip Fracture Risk from Clinical DXA-images

Kan risk för benbrott spås med artificiell intelligens? Höftfrakturer, framförallt benbrott av lårbenshalsen, är ofta ett resultat av benskörhet. Benbrotten drabbar främst äldre personer och leder till sämre livskvalitet; de är även förknippade med högre dödlighet, så hög som 18-33% första året. Även om benskörhet ökar risken för benbrott, är inte alla drabbade bensköra. För att kunna förhindra eOsteoporosis is a bone disease that is defined as low bone mineral density (BMD) and results in an increased risk of bone fracture. It is a serious public health problem that causes excess mortality and major economical and social impact. Today there are more than 8.9 million fractures connected to low bone mineral density worldwide. Hip fractures are of particular concern since they are associate