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Where is the 'global' in the European Union's Health Research and Innovation Agenda?

Global Health has not featured as prominently in the European Union (EU) research agenda in recent years as it did in the first decade of the new millennium, and participation of low-income and middle-income countries (LMICs) in EU health research has declined substantially. The Horizon Europe Research and Innovation Framework adopted by the European Parliament in April 2019 for the period 2021-20

Kinetic and thermodynamic characterization of single-mismatch discrimination using single-molecule imaging

A single-molecule detection setup based on total internal reflection fluorescence (TIRF) microscopy has been used to investigate association and dissociation kinetics of unlabeled 30mer DNA strands. Single-molecule sensitivity was accomplished by letting unlabeled DNA target strands mediate the binding of DNA-modified and fluorescently labeled liposomes to a DNA-modified surface. The liposomes, ac

Combined effect of atmospheric nitrogen deposition and climate change on temperate forest soil biogeochemistry: A modeling approach

Atmospheric N deposition is known to severely impact forest ecosystem functioning by influencing soil biogeochemistry and nutrient balance, and consequently tree growth and overall forest health and biodiversity. Moreover, because climate greatly influences soil processes, climate change and atmospheric N deposition must both be taken into account when analysing the evolution of forest ecosystem s

An inductorless 300MHz wideband CMOS power amplifier

The power amplifier tends to be one of the most demanding parts to fully integrate when building an entire radio on a CMOS chip. In this paper the design of a fully integrated RF power amplifier without inductors is described. As inductors in CMOS technology are associated with various problems, it is interesting to examine what performance can be achieved without them. An amplifier with an operat

Monoclonal gammopathy of undetermined significance and risk of lymphoid and myeloid malignancies: 728 cases followed up to 30 years in Sweden.

In 728 Swedish cases of monoclonal gammopathy of undetermined significance (MGUS), followed up to 30 years (median 10 years), we estimated the cumulative risk of hematologic disorders originating from lymphoid and myeloid lineages. Using Cox regression models, we examined associations of demographic and laboratory factors with progression and determined the discriminatory power of three prediction

Moped and motorcycle accidents--similarities and discrepancies

Injury patterns and epidemiologic data from 211 moped accident victims and 214 motorcycle accident casualties admitted to hospital over a 5-year period (1977-1981) have been analyzed and compared. The number of those injured in motorcycle accidents tripled; the number of moped accident victims slightly decreased in the period studied. Differences in injury pattern, sex ratio, cause of accident, an

Myoelectric Control for Hand Prostheses

Popular Abstract in Swedish Denna avhandling syftar till att förbättra styrningen av myoelektriska handproteser. De primära målen har varit (1) att generera korrekt kontroll för så många handrörelser som möjligt, (2) att förbättra träningsförfarandet så att operatören på ett intuitivt sätt snabbt kan bemästra ett flertal rörelser och (3) att minska tiden som behövs för att matematiskt justera in sAn investigation of improvements of myoelectric prostheses has been undertaken. The primary aims of this thesis were (1) to generate an accurate prediction of as many hand movement as possible, (2) to produce a training setup for subjects allowing intuitive and instant control over multiple movements, and (3) to reduce the training cycle for the control system to a maximum of a couple of minutes t

The Provision of Conflicting Public Goods. Incompatibilities among Trade Regimes and Environmental Regimes

From its early days, the academic debate on public goods has focused on discrepancies or trade-offs regarding the provision of public goods on the one hand and private goods on the other. However, both the extension of the public domain and an increasing interdependence in international relations clearly drive the expansion of an agenda in which there are a growing number of cases where public goo

Development of the Lund AMS facility for the detection of Al-26 -- with applications in plant ecology

Popular Abstract in Swedish Utveckling av AMS-systemet i Lund för detektion av 26Al – med tillämpningar inom växtekologin Den konventionella metoden för att mäta mängden radioaktivt material i ett prov är att detektera strålningen som kommer från provet. Om man vet halveringstiden (den tid det tar för mängen radioaktivt material minska till hälften) så kan man bestämma antalet radioaktiva atomer Accelerator mass spectrometry (AMS) is a highly sensitive technique to count atoms. The method has a high efficiency, which makes it possible to measure small samples in a relatively short time, usually less than an hour. During the work for this thesis, methods have been developed to detect Al-26 at the Lund AMS facility. This includes the design, installation and testing of a new injector that i

Cost effectiveness of haemophilia treatment: a cross-national assessment.

The aim of this study was to assess the incremental cost effectiveness of on-demand versus prophylactic haemophilia therapy in Germany, Sweden, the United Kingdom and The Netherlands from the third-party payers' perspective. Using a decision tree model, the cost effectiveness of on-demand versus prophylactic therapy was analysed by extrapolating data from the European Haemophilia Economic Study to

Subcutaneous alemtuzumab vs ATG in adjusted conditioning for allogeneic transplantation: influence of Campath dose on lymphoid recovery, mixed chimerism and survival.

Sixty-nine consecutive patients ( median age 54 years) were prospectively enrolled in a single-institution protocol for allogeneic transplantation with adjusted non-myeloablative fludarabine - melfalan-based conditioning including cyclosporin A and MMF, and one of three modes of serotherapy. Thirty-one donors (45%) were unrelated. The first cohort of 29 had ATG (Thymoglobulin 2 mg/kg x 3 days), th

Visibility of the environmental noise modulating population dynamics

Characterizing population fluctuations and their causes is a major theme in population ecology. The debate is on the relative merits of density-dependent and density-independent effects. One paradigm (revived by the research on global warming and its relation to long-term population data) states that fluctuations in population densities can often be accounted for by external noise. Several empiric

Search for squarks and gluinos in events with isolated leptons, jets and missing transverse momentum at root s=8 TeV with the ATLAS detector

The results of a search for supersymmetry in final states containing at least one isolated lepton (electron or muon), jets and large missing transverse momentum with the ATLAS detector at the Large Hadron Collider are reported. The search is based on proton-proton collision data at a centre-of-mass energy root s = 8 TeV collected in 2012, corresponding to an integrated luminosity of 20 fb(-1). No

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The essay is an attempt to distinguish between the semantic notion of "childfree" and that of "voluntary childlessness" taking into account the Russian specifics. The author consistently describes socio-political content of the Russian research field emphasizing the conservative pro-natal trends of the recent years. The paper considers the origins of the conceptual field of non-parenthood and the

Compact, high-repetition-rate OPCPA system for high harmonic generation

A compact, high-repetition rate optical parametric chirped pulse amplifier system emitting CEP-stable, few-cycle pulses with 10 μJ of pulse energy is reported for the purpose of high-order harmonic generation. The system is seeded from a commercially available, CEP-stabilized Ti:sapphire oscillator, delivering an octave-spanning spectrum from 600-1200 nm. The oscillator output serves on the one ha

Holocene glacial history and sea level changes on James Ross Island, Antarctic Peninsula

A reconstruction of deglaciation and associated sea-level changes on northern James Ross Island, Antarctic Peninsula, based on lithostratigraphical and geomorphological studies, shows that the initial deglaciation of presently ice-free areas occurred slightly before 7400 14C yr BP. Sea-level in connection with the deglaciation was around 30 m a.s.l. A glacier readvance in Brandy Bay, of at least 7

An isogeometric finite element approach to fibre-reinforced composites with fibre bending stiffness

In the modelling of fibre-reinforced composites, it is well established to consider the fibre direction in the stored energy in order to account for the transverse isotropy of the overall material, induced by a single family of fibres. However, this approach does not include any length scale and therefore lacks in the prediction of size effects that may occur from the fibre diameter or spacing. By

Essentially Indexical Higher-Order Thoughts and Dispositions of Inexistent Mental States

In a recent paper, Miguel Sebastián has posed an objection to the higherorder thought theory of consciousness. The higher-order thought theory of consciousness holds that a mental state is conscious when it is the intentional object of a higher-order thought (HOT). Often, the HOT is conceived to be essentially indexical. This means that the HOT somehow picks out the individual who tokens it. Sebas

Cancer Treatment and End-of-Life Care

AIM: To study to what extent tumor-specific treatment (chemo- or radiotherapy) was given during the last 30 days in life and to examine how many of the patients were referred to a specialized palliative care unit (PCU), at a low-resource governmental hospital in India.PATIENTS AND METHODS: Medical records of adult cancer patients deceased between April 1 and May 31 in 2016, and pediatric cancer pa