Filtyp
GTP hydrolysis is a biologically crucial reaction, being involved in regulating almost all cellular processes. As a result, the enzymes that catalyze this reaction are among the most important drug targets. Despite their vital importance and decades of substantial research effort, the fundamental mechanism of enzyme-catalyzed GTP hydrolysis by GTPases remains highly controversial. Specifically, ho
Recent years have seen tremendous effort in the development of approaches with which to obtain quantum mechanics/molecular mechanics (QM/MM) free energies for reactions in the condensed phase. Nevertheless, there remain significant challenges to address, particularly, the high computational cost involved in performing proper configurational sampling and, in particular, in obtaining ab initio QM/MM
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of methylxanthines in preventing or treating intermittent hypoxemia or respiratory insufficiency in late preterm infants.
In this paper, we present a multipath-based simultaneous localization and mapping (SLAM) algorithm that con-tinuously adapts mulitiple map feature (MF) models describing specularly reflected multi path components (MPCs) from flat surfaces and point-scattered MPCs, respectively. We develop a Bayesian model for sequential detection and estimation of interacting MF model parameters, MF states and mob
Parkinson's disease is a neurodegenerative condition characterized by motor impairments caused by the selective loss of dopaminergic neurons in the substantia nigra. Levodopa is an effective and well-Tolerated dopamine replacement agent. However, levodopa provides only symptomatic improvements, without affecting the underlying pathology, and is associated with side effects after long-Term use. Cel
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Popular Abstract in Swedish Markfosfor och mångfald av växter i svenska gräsmarker – en populärvetenskaplig sammanfattning Olika typer av gräsmarkshabitat innehåller en stor och viktig del av mångfalden av växtarter i Skandinavien och i norra Europa. En stor del av arterna är knutna till kulturlandskapet och des's äldre hävdformer. Förändringar i användning och skötsel av gräsmarkerna under detThe semi-natural grassland habitats contain an important part of the plant diversity in Europe. Changes in farming practices have lead to drastic decreases in plant species richness. The aim of the present thesis is to contribute to the knowledge about mechanisms governing the plant species richness in grasslands with emphasis on soil nutrients. Most species rich grasslands are found on soils with
The damage caused by the worldwide increase in natural disasters is staggering, with the poor and marginalised slum communities being the most vulnerable. This paper analyses the key variables and their causal relations underlying the complex system of risk and disaster occurrence in slum areas in El Salvador. Slum dwellers’ views and knowledge are the focus of this inquiry. A better understanding
