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Objective: This study evaluated, in a Swedish setting, the cost effectiveness of fenfluramine (FFA) as an add-on to standard of care (SoC) for reducing seizure frequency in Dravet syndrome, a severe developmental epileptic encephalopathy. Methods: Cost effectiveness of FFA+SoC compared with SoC only was evaluated using a patient-level simulation model with a lifetime horizon. Patient characteristi
The executive committee of the European Society for the clinical evaluation of balance disorders meets annually to address equilibrium problems that are not well understood. This is a review paper on discussions in the latest meeting we held. Materials and methods: Seeing patients with vestibular disorders who end up depending on visual information as part of their compensation process is a common
The European Environmental Research Infrastructures (ENVRI) community, in its pursuit of enabling seamless and FAIR (Findable, Accessible, Interoperable, and Reusable) access to environmental research data and services, has realised the ENVRI Catalogue of Services. This paper provides an in-depth look into the creation of this tool, highlighting the process, the challenges faced, and the scientifi
Charge-dependent two- and three-particle correlations measured in Xe–Xe collisions at sNN=5.44 TeV are presented. Results are obtained for charged particles in the pseudorapidity range |η|
Crop pests, such as aphids and bark beetles, represent a big challenge for agriculture worldwide. Due to their high adaptability and more suitable conditions because of climate change, they can thrive on a large number of hosts. One of the strategies to control the population of these pests in agricultural areas is the use of pheromones, either to lure them, repel them or to attract predators as a
Academic journals, archives, and repositories are seeing an increasing number of questionable research papers clearly produced using generative AI. They are often created with widely available, general-purpose AI applications, most likely ChatGPT, and mimic scientific writing. Google Scholar easily locates and lists these questionable papers alongside reputable, quality-controlled research. Our an
To resolve the various types of biological ice nuclei (IN) with atmospheric models, an extension of the empirical parameterization (EP) is proposed to predict the active IN from multiple groups of primary biological aerosol particles (PBAPs). Our approach is to utilize coincident observations of PBAP sizes, concentrations, biological composition, and ice nucleating ability. The parameterization or
The ongoing war in Ukraine is associated with unprecedented radiological threats to the public in Ukraine and the neighboring countries. This calls for fundamental revision of the preparedness plans and established approaches to radiological monitoring of the populations affected by potential radiological emergencies. Dosimetric information will be needed for triage of victims and support to decis
In vitro digestion studies often use animal digestive enzyme extracts as substitutes of human gastric and pancreatic secretions. Pancreatin from porcine origin is thus commonly used to provide relevant pancreatic enzymes such as proteases, amylase and lipase. Rabbit gastric extracts (RGE) have been recently introduced to provide gastric lipase in addition to pepsin. Before preparing simulated gast
Thousands of barley (Hordeum vulgare L.) mutants have been isolated over the last century, and many are stored in gene banks across various countries. In the present work, we developed a pipeline to efficiently identify causal mutations in barley. The pipeline is also efficient for mutations located in centromeric regions. Through bulked segregant analyses using whole genome sequencing of pooled F
Stimuli-responsive polymer nanoparticles were synthesized by surfactant-free dispersion polymerization of styrene and 2-(dimethylamino)ethyl methacrylate (DMAEMA) in three different contents of divinylbenzene intraparticle crosslinking agent. Incorporation of the hydrophilic DMAEMA comonomer during the polymerization yielded pH-responsive nanogels with a higher size than the polystyrene nanopartic
Background: Alzheimer's disease (AD) is a neurodegenerative disorder caused by a complex interplay of various factors. However, a satisfactory cure for AD remains elusive. Pharmacological interventions based on drug targets are considered the most cost-effective therapeutic strategy. Therefore, it is paramount to search potential drug targets and drugs for AD. Objective: We aimed to provide novel
AIMS: The aim of this study was to identify and describe methods that physiotherapists use to evaluate the immediate effects of their interventions for infants in hospital with acute respiratory tract infections.METHODS: We constructed an anonymous digital survey to physiotherapists working with infants aged 0-24 months in Sweden. The survey was distributed by e-mail and posted on web pages for se
There is a lack of knowledge among food manufacturers about adopting the Internet of Things (IoT)-based water monitoring system and its ability to support water minimisation activities. It is therefore necessary to investigate the applicability of IoT-based real-time water monitoring systems in a real food manufacturing environment to pursue water-saving opportunities accordingly. This article aim
In this work, a computationally efficient evolutionary algorithm is proposed for estimating the direction of arrival (DOA) of coherently distributed (CD) sources corrupted by additive impulsive noise. The typical method, such as distributed signal parameter estimation (DSPE) method, requires a 2-D spectral peak search and cannot allow for coherent signals. The proposed method in this article uses
During the first year of NASA's Mars 2020 mission, Perseverance rover has investigated the dark crater floor unit of Jezero crater and four samples of this unit have been collected. The focus of this paper is to assess the potential of these samples to calibrate the crater-based Martian chronology. We first review the previous estimation of crater-based model age of this unit. Then, we investigate
Precipitation is a major component of the water cycle. Accurate and reliable estimation of precipitation is essential for various applications. Generally, there are three main types of precipitation products: satellite based, reanalysis, and ground measurements from rain gauge stations. Each type has its advantages and disadvantages. Recent efforts have been made to develop various merging methods
BACKGROUND: Accessibility to surgical services can impact earthquake preparedness and response. We aimed to estimate the population with timely access to surgical care in Guerrero, a Mexican state with high tectonic activity, and identify populations at risk in the event of an earthquake.METHODS: We conducted an ecological study using open government data. We extracted data from Guerrero municipal
Strategy is considered one of the most central concepts in public relationsresearch and practice. However, public relations strategizing, i.e., the doingof strategy, remains a black-box concept in public relations and wouldbenefit from additional approaches to theorizing strategy. This conceptualarticle draws upon strategy-as-practice, practice theory, and the existentialistnotion of human modes o
Streamflow estimation is important in hydrology, especially in drought and flood-prone areas. Accurate estimation of streamflow values is crucial for the sustainable management of water resources, the development of early warning systems for disasters, and for various applications such as irrigation, hydropower production, dam sizing, and siltation management. This study developed the ANN algorith
