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Despite progress in use of decellularized lung scaffolds in ex vivo lung bioengineering schemes, including use of gels and other materials derived from the scaffolds, the detailed composition and functional role of extracellular matrix (ECM) proteoglycans (PGs) and their glycosaminoglycan (GAG) chains remaining in decellularized lungs, is poorly understood. Using a commonly utilized detergent-base
The cellular and molecular mechanisms underlying specification of human hematopoietic stem cells (HSCs) remain elusive. Strategies to recapitulate human HSC emergence in vitro are required to overcome limitations in studying this complex developmental process. Here, we describe a protocol to generate hematopoietic stem and progenitor-like cells from human dermal fibroblasts employing a direct cell
BACKGROUND: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear. METHODS: We performed single and combined multiple instrumental variable Mendelian randomization analysis by an inverse-weighted method, in addition to a
Most peripheral serotonin (5-hydroxytryptamine (5HT)) is synthetized in the gut with platelets being its main circulating reservoir. 5HT is acting as a hormone in key organs to regulate glucose and lipid metabolism. However, the relation between platelet 5HT levels and traits related to glucose homeostasis and lipid metabolism in humans remains poorly explored. The objectives of this study were (a
OBJECTIVE: HER2/ErbB2 is a member of the epidermal growth factor receptor family. It is widely used as a tumor marker, but it also has recently been associated with insulin resistance. Both ErbB2 and diabetes have been associated with cancer; however, the relationship between ErbB2 and diabetes has not been well explored. The aim of this population-based cohort study was to assess the association
BACKGROUND AND AIMS: Atherosclerotic plaques are the leading cause of cardiovascular events. Single-cell approaches have identified diverse human plaque cell phenotypes but their spatial distribution and interactions remain unclear. Here, intercellular communication patterns in human plaque microenvironments were mapped to reveal novel targets to prevent atherosclerotic events.METHODS: Spatial tra
Hexavalent chromium (Cr(VI)) can induce oxidative stress, genomic instability, and epigenetic modifications. In occupational settings, Cr(VI)-exposed workers may also be exposed to other toxicants, such as elements besides Cr, and per- and polyfluoroalkyl substances (PFAS). However, research on the extent of these co-exposures and their combined effects remains limited. The objective of this study
Phage collections are essential tools for discovering and dissecting bacterial anti-phage defense systems. Here, we report the isolation, characterization, and annotated genome sequences of five environmental Escherichia coli-infecting phages, obtained during the 2023 Fundamentals of Basic and Applied Phage Biology course at Lund University. The phages were isolated using a motile E. coli K-12 BW2
1 M al m ö A rt A ca de m y 20 17 – 20 18 Masters of Fine Arts – Year 1 Masters of Fine Arts – Critical & Pedagogical Studies – Year 1 Bachelor of Fine Arts – Year 2 Bachelor of Fine Arts – Year 1 2M al m ö A rt A ca de m y M al m ö A rt A ca de m y 20 17 – 2 01 8 20 17 – 2 01 8 20 17 – 2 01 8 3 Andreas Bentdal Amble Rannveig Jónsdóttir Carl-Oskar Jonsson Cecilia Kanthi Jonsson Gabriel Karls
https://www.khm.lu.se/en/sites/khm.lu.se.en/files/yearbook2_2018.pdf - 2026-05-30
Microsoft Word - Elmar Nurmemmedov - Thesis Final Version.doc Lund University International Master’s Program in Environmental Science MASTER THESIS BIO-ENTREPRENEURIAL PARTNERSHIP – A TOOL FOR BIOTECHNOLOGY TRANSFER A Systems of Innovation Approach By Elmar Nurmemmedov Elmar.Nurmemmedov@mbfys.lu.se Lund, Sweden 2004 To The Golden Generation Whose Shadows Hue The Horizons… ii ABSTRACT The current p
https://www.lumes.lu.se/sites/lumes.lu.se/files/nurmemmedov_elmar.pdf - 2026-05-30
In the hushed morning after San Cristobal's New Year's celebration in 1994, hundreds of masked rebels moved through the empty The Role of Environmental Scarcity in Nepal’s Maoist Insurgency Master’s Thesis by: Micah Sherman Submitted on February 24th, 2003 Supervisor: Thomas Malm Lund University International Master’s Programme in Environmental Science, LUMES Micah Sherman c/o LUMES Box 170 221 00
https://www.lumes.lu.se/sites/lumes.lu.se/files/sherman_micah.pdf - 2026-05-30
Objectives: . SLE is an autoimmune disease with increased cardiovascular morbidity and platelet activation. In the general population, increased platelet size predicts platelet reactivity and cardiovascular disease. The aim of this study was to investigate whether platelet size related to platelet activation and cardiovascular disease in SLE.Methods: . Fresh blood samples from SLE patients ( n = 1
Since its development in the 1980s, spark ablation has been widely used to produce nanoparticles (NPs) in the aerosol phase, effectively eliminating surface contamination common in other generation methods (Schmitt-Ott, 2019). This is a significant advantage, as the surface of NPs plays a crucial role in applications such as sensing and catalysis. Additionally, spark ablation enables the productio
IMPORTANCE Risk stratification strategies in primary prevention of coronary events lack precision. OBJECTIVE To determine whether prediction of first coronary events is improved by adding information on coronary atherosclerosis from coronary computed tomography angiography (CCTA) to a model using the pooled cohort equation (PCE) risk score tool and the coronary artery calcification score (CACS). D
Glycophospholipids combine the structural versatility of phospholipids and carbohydrates, but their potential as excipients and performance in other related applications remains largely unexplored due to their low natural abundance. We have synthesized four novel phosphatidyl saccharide conjugates with different carbohydrate head groups; glucose, galactose, fructose and xylose by using a Phospholi
There is a positive association between bacteraemia with Streptococcus bovis-Streptococcus equinus complex (SBSEC) and colorectal cancer (CRC). However, the relationship between the timing of SBSEC bacteraemia and CRC is not well-established. Associations with other gastrointestinal cancers have also been suggested. Using national registries, we retrospectively examined the incidence of CRC and ot
Introduction: There is no recommendation regarding the optimal prime solution for the cardiopulmonary bypass circuit in adult cardiac surgery. Despite the lack of scientific evidence, mannitol has frequently been added to the prime solution with intention to prevent acute kidney injury. The aim of this study was to investigate the impact of mannitol in cardiopulmonary bypass circuit prime in patie
