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Introduction: Under-dosing is a recognized problem with current nicotine replacement therapy (NRT). Therefore, a new 6mg nicotine gum has been developed. To compare the nicotine uptake from the 6mg gum versus currently available NRT products, two pharmacokinetic studies were performed.Methods: In one randomized crossover study, 44 healthy adult smokers received single doses of 6, 4, and 2mg nicoti
We have developed a method to separate bacteria from red and white blood cells (henceforth collectively called blood cells) using acoustophoresis, for subsequent PCR detection. To maximize throughput, we have now investigated the effect of increased cell concentration on the separation. Increasing the blood concentration drastically decreases bacteria recovery, but we show that this can be remedie
Purpose: Recently, there has been increasing interest in the use of dual mobility systems in the treatment of hip instability. The aim of this study was to investigate the re-revision rate of dual mobility cup compared to different surgical concepts when used for first-time hip revisions due to recurrent dislocations. Methods: The data were derived from the Lithuanian Arthroplasty Register. For su
Gebel el Silsila (Mountain of Chain) is located between Kom Ombo and Edfu on both banks of the Nile where it reaches its narrowest point. The site is generally known for its many Pharaonic cenotaphs, stelai and the speos of Horemheb, but it was once also the world’s largest quarry. As such it was renowned for its high quality sandstone, and the stone was extracted and transported to all over Upper
In economic and management literature, the relationship between supplier and buyer can be more or less intimate. It can vary from market-driven with a constant change of suppliers to a value-driven relationship with one sole supplier. Purchasing strategies of construction companies have often been described as short-sighted, where price is the most considered aspect. Recent lean management literat
We present a method to first laterally position microparticles inside droplets by acoustic forces and then split the droplet into three daughter droplets to achieve a 2+fold enrichment of microparticles inside the center droplet. We show that acoustic forces can be applied to both manipulate polystyrene beads (5 μm) and red blood cells inside droplets. The presented technology opens up for develop
Carbonyl exchange between [MX3(13CO)]–(MX = PdCl, PtCl or PtBr) and 12CO has been studied by IR and 13C NMR spectroscopies as a function of temperature. The exchange is first-order in both CO and complex concentration, and the activation entropies are negative, suggesting an associative reaction mechanism. There is a small solvent effect, but no chloride dependence. Activation parameters and rate Carbonyl exchange between [MX(3)((CO)-C-13)](-) (MX = PdCl, PtCl or PtBr) and (CO)-C-12 has been studied by IR and C-13 NMR spectroscopies as a function of temperature. The exchange is first-order in both CO and complex concentration, and the activation entropies are negative, suggesting an associative reaction mechanism. There is a small solvent effect. but no chloride dependence. Activation para
The rate constants for the chloride and bromide anations of Pd(H2O)42+, the chloride anations of PdCl3H2O−, the bromide anation of PdBr3H2O− and the acid hydrolysis of PdCl(H2O)3+, PdBr(H2O)3+, PdCl42−, and PdBr42− have been determined at 15, 25 and 35 °C using a stopped-flow technique. The ionic strength was 1.00 M and the supporting electrolyte perchloric acid. The obtained rate constants and th
Measles virus genotype B3 was isolated from patients during a measles outbreak in Copenhagen starting January 2006. Here we describe three cases: two children aged 9 and 22 months, respectively, and a 29-year-old man. All three patients were hospitalised. Several doctors examined both the children before the diagnosis of measles was established. The patients were not vaccinated against measles. Th
The fracture toughness of a polymer-metal laminate composite is obtained by mechanical testing of a specimen containing a pre-crack. The laminate is a material used for packaging. It consists of a thin aluminium foil and a polymer coating. A centre cracked panel test geometry is used. Each of the layers forming the laminate is also tested separately. The result is compared with the measured fractu
Bi-materials composed of thin layers ideally bonded to large substrates are considered. Cracksemerging from an almost flat surface and propagating through the bi-materials are studied.The cracks acquire realistic geometrical shapes, where the tips are integral parts of the cracksurfaces. Crack propagation is related to surface evolution resulting from material loss due tocorrosion. Controlling mecBi-materials composed of thin layers ideally bonded to large substrates are considered. Cracks emerging from an almost flat surface and propagating through the bi-materials are studied. The cracks acquire realistic geometrical shapes, where the tips are integral parts of the crack surfaces. Crack propagation is related to surface evolution resulting from material loss due to corrosion. Controlling
Ta några ingenjörsstudenter, släng in ett par kognitionsvetarstudenter och ge dem ett problem att lösa. Ut kommer interaktiva dataspel för skolan och robotar som kan imitera människors rörelser. – Vi kombinerar doing och thinking, säger Agneta Gulz, professor i kognitionsvetenskap.
In Statistical Shape Modeling, a dense correspondence between the shapes in the training set must be established. Traditionally this has been done by hand, a process that commonly requires a lot of work and is difficult, especially in 3D. In recent years there has been a lot of work on automatic construction of Shape Models. In recent papers (Davies et al., Medical Image Computing and Computer-Ass
Induction of the mitochondrial permeability transition (MPT) has been implicated in cellular apoptosis and in ischemia-reperfusion injury. During MPT, a channel in the inner mitochondrial membrane, the mitochondrial megachannel, opens and causes isolated mitochondria to swell. MPT and mitochondrial swelling is inhibited by cyclosporin A (CsA), which may also inhibit apoptosis in some cells. Treatm
