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Parkinson’s disease (PD) is considered one of the most frequent neurodegenerative disorders amongst elderly people. PD leads to loss of dopaminergic neurons in substantia nigra of the brain giving symptoms such as slowness of movement and dementia. PD brains have been found to contain accumulations of a protein named alpha‐synuclein (α‐syn). Additional to its aggregation propensity in PD it is als
This thesis investigates how impact assessment can contribute to organisational learning and whether there are ways to enhance it. To answer these questions, the research takes a form of a qualitative case study carried out in collaboration with the non-profit organisation Reach for Change which represents a single case. The research data is drawn from two primary sources of evidence: organisation
In a world where the problem of energy resources, pollution and all aspects related to these issues becomes more and more dominant, a greater commitment is needed in the search for solutions. The goal of this project is to make a contribution to the research and development of new materials to reduce the environmental impact in some fields. First of all, we tried to synthesize and prepare an isati
With the evolving technology of mobile electronics and other forms of communication methods, an increasing demand of speech intelligibility is introduced. In a conference room for example, multiple microphones are placed directly in front of the speaker in order to pick up clean speech. However, several challenges still exist. For instance the distance between speaker and microphone will not be fi
Due to increasing global energy demands and a need to move away from non-renewable energy sources, green hydrogen is now being considered as a possible replacement for fossil-based energy sources. Especially in “hard-to-abate” sectors, such as steel and petrochemical production, and long-distance transport, where the change to renewable electricity is more difficult. Green hydrogen is produced thr
A lack of somatostatin expressing interneurons (SST INs) is known to be a factor in several neurodegenerative and neurospsychiatric diseases, such as Alzheimer disease, Parkinson’s disease and schizophrenia. Being able to efficiently obtain SST INs in vitro could enable a greater understanding and better treatment of these diseases. The development of SST INs is not yet fully understood, but it is
The use of antenna arrays allows for direction-of-arrival (DoA) estimation in a radar system. The antenna elements in an array are conventionally positioned equidistantly on a grid, but they can also be placed relatively freely to form sparse antenna arrays. These non-conventional layouts could potentially offer improved DoA capabilities. In this work, a particle swarm optimization algorithm has b
Thymidine kinase 1 from tomato (ToTK1) is a newly discovered deoxyribonucleoside kinase (dNK) that has been subject to study due to its in vitro and in vivo properties making it an interesting suicide gene candidate for the treatment of brain tumors. The ToTK1 phosphorylates the nucleoside analogue 3-azido-2,3-dideoxythymidine (azidothymidine, AZT) equally well as its natural substrate thymidine (
In the present study, the enzyme thymidine kinase 1 from tomato (ToTK1) was expressed in E.coli and purified to near homogeneity by means of affinity chromatography. However, purified ToTK1 of bacterial origin displayed no substantial catalytic activity. Expression was also attempted in insect cells using the baculovirus expression vector system (BEVS). Significant TK activities were detected in t
This thesis covers specification and development of a distributed measurement system intended for CAN bus. It was completed at Scania CV, Södertälje in collaboration with Lund University. The goal of the thesis is to specifiy and develop a distributed measurement system that helps Scania with acquisition of functional and electrical data. Several topics are adressed such as filtering, at what spee
Designing and developing a software product is a difficult process. The product must be usable and solve the correct problem. At the same time, the underlying code must be well written. Many projects fail to deliver or exceed their budget. This thesis explores a practical approach to software design and development that tries to adhere to both user centered design and agile development. The proces
In gas turbine blade modeling a stable but yet flexible method of describing the blade shape is crucial. Polynomials and B ́ezier curves have previously been used and in this paper B-splines are employed instead. This method removes the need for many of the interior derivative conditions on the curve but special care must be taken when selecting the parameter values and appropriate derivative cond
The wide and increasing range of screen sizes between Android devices makes consumers use them very differently. Large devices (like televisions) are more suitable to view content and smaller devices (like smart watches) are to be used more as a quick controller of the main application. Distributed user interfaces is the concept of utilizing several of these de- vices in one application, so that e
The main goal of this project was to use the Modelica features on embedded systems, real-time systems and basic mechanical modeling for the control of a two-wheeled self-balancing personal vehicle. The Elektor Wheelie, a Segway-like vehicle, was selected as the process to control. Modelica is an object-oriented language aimed at modeling of complex systems. The work in the thesis used the Modelica
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Conventional agriculture in Sweden is facing challenges with low resilience to a changing climate and decreased biodiversity. Silvoarable agroforestry is an alternative land use practice that contain a woody perennial and crop in the same field. Trees on cultivated land break up large monocultures, increase biodiversity, creates functional diversity, and produces more commodities. This land use pr
This degree project focused on the evaluation of the facilities, production process and conditions within a brewery production site in order to identify potential contamination risks in the beer production process and suggested actions for improving and enhancing protection against contamination. The project was performed in collaboration with a microbrewing company that produces beers with differ
