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Nanoparticles present enormous surface areas and are found to enhance the rate of protein fibrillation by decreasing the lag time for nucleation. Protein fibrillation is involved in many human diseases, including Alzheimer's, Creutzfeld-Jacob disease, and dialysis-related amyloidosis. Fibril formation occurs by nucleation-dependent kinetics, wherein formation of a critical nucleus is the key rate-
The number of discovered non-radially pulsating white dwarfs (WDs) in cataclysmic variables (CVs) is increasing rapidly by the aid of the Sloan Digital Sky Survey (SDSS). We performed photometric observations of two additional objects, SDSS J133941.11+484727.5 (SDSS 1339), independently discovered as a pulsator by Gansicke et al., and SDSS J151413.72+454911.9, which we identified as a CV/ZZ Ceti h
To investigate the prevalence, distribution, and colonization burden of Staphylococcus aureus (S. aureus) and MRSA in different body sites among people who inject drugs (PWID) and compare it to a control group consisting of non-injectors. In this cross-sectional survey, 49 active PWID from the needle exchange program (NEP) in Malmö, Sweden, and 60 non-injecting controls from an emergency psychiatr
Manufacturing Renaissance, i.e. return of manufacturing to west, has been recently observed. This paper analyzes the patterns observed within each of the four main drivers behind this new phenomenon and delves more deeply into the driver that centers on the new manufacturing technologies such as Additive Manufacturing (AM) and 3D Printing. Next, this paper will make the case that the location of m
Spores of pathogenic fungi are virtually ubiquitous and cause human disease and severe losses in crops. The endophytic fungi Alternaria species produce host-selective phytotoxins. Alt a 1 is a strongly allergenic protein found in A. alternata that causes severe asthma. Despite the well-established pathogenicity of Alt a 1, the molecular mechanisms underlying its action and physiological function r
Bacterial proteases are important enzymes used in several technical applications where controlled cleavage of proteins is needed. They are challenging enzymes to express recombinantly as parts of the proteome can be hydrolyzed by their activity. The eukaryotic model organism Saccharomyces cerevisiae is potentially a good expression host as it tolerates several stress conditions and is known to bet
Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic options. Here, we show that syndecan-4 (SDC4), a transmembrane proteoglycan, is highly expressed in intestinal subtype gastric tumors and that this signature associates with patient poor survival. Further, we mechanistically demonstrate that SDC4 is a master regulator of gastric cancer cell motility and in
Visual information can be integrated in prominence perception, but most available evidence stems from controlled experimental settings, often involving synthetic stimuli. The present study provides evidence from spontaneously produced head gestures that occurred in Swedish television news readings. Sixteen short clips (containing 218 words in total) were rated for word prominence by 85 adult volun
Soil is an interface of the lithosphere, biosphere, hydrosphere and atmosphere that provides a habitat for microbial growth. The microbial biomass forms an integral part of the soil. The physiological potential and diversity of the microbial communities in soils are strongly associated with the physicochemical properties of soils. The biotic and abiotic characteristics determine the structure and
This chapter focuses on communication-centered change research and its implications for public sector organizations. It focuses on the organizational level and the communication processes through which changes are enacted. Special attention is given to coworkers and how they make sense in times of changes. Sensemaking processes play a crucial role in organizational changes; if managers and employe
Circular Economy regulation is rapidly adopted at different levels of governance, including municipalities, private and industry standards, national law and supranational standard-setting. There are increasing demands from policymakers, businesses and civil society for theoretical insights and more knowledge on the effects of policies and laws ('policy learning'). However, despite this mounting in
Modellering av smältavrinning med kort tidsupplösning
Increased shale gas extraction through hydraulic fracturing and its distribution through shale gas pipelines have brought about innumerable socioeconomic consequences, both tangibly and intangibly. Evidence remains unclear on what are the impacts of shale gas developments on property values. By employing a mixed method approach, combining original data collected in the Marcellus Shale through inte
Denna avhandling undersöker skapandet och omvandlingen av offentliga platser i Hongkong, en stad som är genomsyrad av nyliberala ideal och som under senare år har kännetecknats av betydande försämringar när det gäller demokratiska rättigheter och friheter. Som ett resultat av den nyliberala kapitalismens expansion har kommodifieringen av det urbana rummet inte bara förvärrats utan också blivit merThis thesis explores the production and transformation of public spaces in Hong Kong, a city that is steeped in neoliberal ideals and has seen substantial deterioration in terms of democratic rights and freedoms in recent years. As a result of the expansion of neoliberal capitalism, commodification of urban space has not only exacerbated, but also become more far-reaching and indiscriminate. While
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, in which prognosis is determined by liver fibrosis. A common variant in hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13, rs72613567-A) is associated with a reduced risk of fibrosis in NAFLD, but the underlying mechanism(s) remains unclear. We investigated the effects of this variant in the human liver and in Hsd17
OBJECTIVE: The aim of the study was to investigate the associations of total sleep time (TST) and occupational stress based on the Brief Job Stress Questionnaire (BJSQ) with cholesterol levels in an occupational cohort of Japanese office workers. METHODS: The present study is a secondary analysis of a subset of participants from a randomized controlled trial. Participants were 179 employees from 5
The disease COVID-19 has developed into a worldwide pandemic. Hyperinflammation and high levels of several cytokines, for example, IL-6, are observed in severe COVID-19 cases. However, little is known about the cellular origin of these cytokines. Here, we investigated whether circulating leukocytes from patients with COVID-19 had spontaneous cytokine production. Patients with hyperinflammatory COV
This study investigated the emission of PM10 and PM2.5 (particulates with diameters of less than 10 µm and 2.5 µm, respectively) and the chemical composition of PM2.5 from laboratory combustion of five Australian vegetation types (three grasslands, a woodland and a forest). A mix of plants representative of Banksia (woodland) and Jarrah (forest) and three types of grasses (Spinifex – Triodia based
Providing and assuring safe conditions for personnel is a key parameter required to operate the European Spallation Source (ESS). The Personnel Safety System (PSS) primarily prevent workers from the facility's ionising radiation hazards, but also identify as well as mitigate against all other hazards such as high voltage and oxygen depletion. The PSS test stand is being developed in the ESS Protec
Transcription factors normally regulate gene expression through their action at sites where they bind to DNA. However, the balance of activating and repressive functions that a transcription factor can mediate is not completely understood. Here, we showed that the transcription factor PU.1 regulated gene expression in early T cell development both by recruiting partner transcription factors to its
