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Owing to their extreme crowding and high and variable extinction, stars in the Galactic Bulge, within ±2° of the Galactic plane, and especially those in the Nuclear Star Cluster, have only rarely been targeted for an analyses of their detailed abundances. There is also some disagreement about the high end of the abundance scale for these stars. It is now possible to obtain high dispersion, high S/
The protein-lipid complex alpha1-oleate, derived from HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells), is identified as a molecular entity with significant therapeutic potential. Structural characterization of the complex and results of a successful placebo-controlled clinical trial are presented.
Partially unfolded alpha-lactalbumin forms the oleic acid complex HAMLET, with potent tumoricidal activity. Here we define a peptide-based molecular approach for targeting and killing tumor cells, and evidence of its clinical potential (ClinicalTrials.gov NCT03560479). A 39-residue alpha-helical peptide from alpha-lactalbumin is shown to gain lethality for tumor cells by forming oleic acid complex
The summer precipitation (June–September) in the source region of the Yellow River accounts for about 70% of the annual total, playing an important role in water availability. This study divided the source region of the Yellow River into homogeneous zones based on precipitation variability using cluster analysis. Summer precipitation trends and teleconnections with global sea-surface temperatures
Background: Eosinophils are innate immune cells present in the intestine during steady state conditions. An intestinal eosinophilia is a hallmark of many infections and an accumulation of eosinophils is also observed in the intestine during inflammatory disorders. Classically the function of eosinophils has been associated with tissue destruction, due to the release of cytotoxic granule contents.
Mechanical damage at the time of joint injury and the ensuing inflammatory response associated with elevated levels of pro-inflammatory cytokines in the synovial fluid, are reported to contribute to the progression to osteoarthritis after injury. In this exploratory study, we used a targeted proteomics approach to follow the progression of matrix degradation in response to mechanical damage and cy
The 1976 premiere of Face to Face came at the height of director-screenwriter Ingmar Bergman's career. Prestigious awards and critical acclaim had made him into a leading name in European art cinema, yet today Face to Face is a largely overlooked and dismissed work.This book tells the story of its rise and fall. It presents a new portrait of Bergman as a political artist exploring a new medium wit
The αE integrin chain CD103 identifies a subset of migratory dendritic cells (DCs) in the gut, lung, and skin. To gain further understanding of the function of CD103(+) DCs in regulating adaptive immunity in vivo, we coupled ovalbumin (OVA) to the CD103 antibody M290 (M290.OVA). Intraperitoneal injection of M290.OVA induced OVA-specific CD8(+) and CD4(+) T-cell proliferation in lymph nodes (LNs) o
Current treatments that are efficient in controlling effector T cells responses to allografts have limited efficacy on the accelerated rejection mediated by memory T cells. Effective targeting of alloreactive memory T cells may therefore be explored to improve therapeutic approaches towards solving this problem. In this study, we investigated the synergistic effect of CD44/CD70 blockade and anti-C
Atypical hemolytic uremic syndrome has been associated with dysregulation of the alternative complement pathway. In this study, a novel heterozygous C3 mutation was identified in a factor B-binding region in exon 41, V1636A (4973 T > C). The mutation was found in three family members affected with late-onset atypical hemolytic uremic syndrome and symptoms of glomerulonephritis. All three patients
This thesis will be concerned with one of the main concerns and highly discussed topics in the relationship between Article 102 TFEU and Intellectual Property Rights. Predominately, it will focus on the enforcement of IPR(s) as an abusive practise of dominance and whether a dominant undertaking has the ability to protect its IPR by refusing to licence its IPR to a third party. The main purpose wi
This research outlines the evolution of the manufacturing and industrial export structure of countries, Estonia, Lithuania, and Latvia since 1992 within the framework of Economic Complexity and the Product Space. The research reveals a relatively low level of specialization in the countries’ export structures and identifies a dual structure within the economy due to the foreign ownership of firms.
Like many other international human rights law instruments, the 1951 Convention relating to the Status of Refugees was written from a male perspective, which has resulted in that the refugee definition of the Convention historically has been interpreted through a framework of male experiences. For this reason, many asylum claims of female applicants have been ignored. In order to be granted refug
By analysing two different Female Gothic novels, this thesis aims to explore the different ways in which masculinity is portrayed within the Female Gothic literary tradition, more specifically the Early Gothic and Victorian Gothic due to constraints in scope. The novels chosen, The Mysteries of Udolpho (1794) and Uncle Silas (1864), are in many ways representative and serve as typical Female Gothi
An anti-estradiol antibody with improved specificity is searched for by combining steroid analog binding studies, mutant antibodies obtained from a phage-display library and structural modeling. Three-dimensional models for the anti-estradiol antibody 57-2 were constructed by comparative model building. Estradiol and analogs were docked into the combining site and molecular dynamics simulation was
Candelaria pacifica is formally described. It is currently known from North and South America and Europe. The species is characterized by a small, lobate thallus with soredia formed on the lobe tips and along the margins. It has been confused with C. concolor in Europe and North America, but differs in having 8-spored asci and in lacking a lower cortex. Candelaria vulgaris, the type species of the
