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Making hot Jupiters in stellar clusters: The importance of binary exchange

It has been suggested that the occurrence rate of hot Jupiters (HJs) in open clusters might reach several per cent, significantly higher than that of the field (~a per cent). In a stellar cluster, when a planetary system scatters with a stellar binary, it may acquire a companion star, which may excite large-amplitude von Zeipel-Lidov-Kozai oscillations in the planet's orbital eccentricity, trigger

Successes and shortcomings of phonological accounts of Scandinavian object shift

Object shift (OS) is a word order phenomenon in Scandinavian languages where under some circumstances the object appears before a sentential adverb. Despite the frequent assumptions that word order is determined in syntax, and despite the link of OS and syntactic phenomena like V2, there is no consensus that OS is a syntactic phenomenon. Particularly, it has been observed that OS targets specifica

Kidney Disease in Childhood Cancer Survivors

Chronic glomerular and tubular nephrotoxicity has been reported in up to 50% and 25%, respectively, of children and adolescents treated with ifosfamide and up to 60% and 30% of those given cisplatin. Up to 35% of children have proteinuria and microalbuminuria, implying chronic glomerular damage, after unilateral nephrectomy for a renal tumour. We are still learning about nephrotoxicity due to the

Clinical insights into small cell lung cancer : Tumor heterogeneity, diagnosis, therapy, and future directions

Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity. It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority of SCLCs exhibit neuroendocrine features, an important subset of tumors lacks these properties. Genomic profiling of SCLC reveals genetic instability, almost universal inactivation of the tumor suppressor genes TP5

Comparison of four clinical risk scores in comatose patients after out-of-hospital cardiac arrest

Background and aims: Several different scoring systems for early risk stratification after out-of-hospital cardiac arrest have been developed, but few have been validated in large datasets. The aim of the present study was to compare the well-validated Out-of-hospital Cardiac Arrest (OHCA) and Cardiac Arrest Hospital Prognosis (CAHP)-scores to the less complex MIRACLE2- and Target Temperature Mana

Synchrotron XPS and Electrochemical Study of Aging Effect on Passive Film of Ni Alloys

To investigate aging effect on the passive film of Ni23Cr15Mo and Ni22Cr9Mo3Nb, synchrotron-based X-ray photoelectron spectroscopy (XPS) was used to analyze the structure and composition of the air-formed passive film on the alloys. The corrosion resistance of the two Ni alloys in 1 M NaCl solution was evaluated with electrochemical cyclic polarization measurement. The synchrotron XPS measurement

Life-cycle assessment of yeast-based single-cell protein production with oat processing side-stream

Production of fish meal and plant-based feed proteins continues to increase to meet the growing demand for seafood, leading to impacts on marine and terrestrial ecosystems. Microbial proteins such as single-cell proteins (SCPs) have been introduced as feed alternatives since they can replace current fish feed ingredients, e.g., soybean, which are associated with negative environmental impacts. Mic

Metabolically (un)healthy obesity and risk of obesity-related cancers : a pooled study

BACKGROUND: Studies of obesity with or without metabolic aberrations, commonly termed metabolically unhealthy or healthy obesity, in relation to cancer risk are scarce.METHODS: We investigated body mass index (BMI, normal weight/overweight/obesity) jointly and in interaction with metabolic health status in relation to obesity-related cancer risk (n = 23,630) among 797,193 European individuals. A m

Consumer Trust and Platformised Retail Personalisation

As retail is becoming increasingly digitised in its operation and consumer relationships, much faith is put into automation, prediction and insights drawn from consumer data to shape consumer experiences and expectations. Under the umbrella of data-collection and artificial intelligence (AI), this chapter studies the role of consumer trust in retail personalisation. We draw empirical insights from

Major histocompatibility complex class I binding glycopeptides for the estimation of 'empty' class I molecules

Different forms of major histocompatibility complex (MHC) class I heavy chains are known to be expressed on the cell surface, including molecules which are functionally 'empty'. Direct peptide binding to cells is obvious during sensitization of target cells in vitro for cytotoxic T lymphocyte killing and 'empty' MHC-I molecules are comparatively abundant on TAP- 1 2 peptide transporter mutant cell

Complex dynamics of water quality mixing in a warm mono-mictic reservoir

Cycling of water quality constituents in lakes is affected by thermal stratification and homo-thermal conditions and other factors such as oligotrophication, eutrophication, and microbial activities. In addition, hydrological variability can cause greater differences in water residence time and cycling of constituents in man-made lakes (reservoirs) than in natural lakes. Thus, investigations are n

4-quinolone antibiotics : Positive genotoxic screening tests despite an apparent lack of mutation induction

The effects of different 4-quinolone antibiotic derivatives (4-Qs) in a number of short-term tests commonly employed for the evaluation of genetic toxicity were studied. Incorporation of [3H]thymidine into mitogen-stimulated peripheral blood lymphocytes was strongly enhanced at a low concentration (1.56 μg/ml) for most of the tested 4-Qs, whereas DNA strand breakage in lymphoblastoid cells was evi

Evaluation of a Novel Immunoassay for Quantification of C1q for Clinical Diagnostic Use

Objectives: C1q is a valuable biomarker of disease activity in systemic lupus erythematosus (SLE). The "gold standard" assay, rocket immunoelectrophoresis (RIE), is time-consuming, and thus a shift to soluble immune precipitation techniques such as nephelometry has occurred. However, quantification of C1q with these techniques has been questioned as a result of the antibody binding properties of C

Biotechnological Potential of Bdellovibrio and Like Organisms and Their Secreted Enzymes

Bdellovibrio and like organisms (BALOs) are obligate predatory bacteria that selectively prey on a broad range of Gram-negative bacteria, including multidrug-resistant human pathogens. Due to their unique lifestyle, they have been long recognized as a potential therapeutic and biocontrol agent. Research on BALOs has rapidly grown over the recent decade, resulting in many publications concerning mo

GFAp and tau protein as predictors of neurological outcome after out-of-hospital cardiac arrest : A post hoc analysis of the COMACARE trial

Aim: To determine the ability of serum glial fibrillary acidic protein (GFAp) and tau protein to predict neurological outcome after out-of-hospital cardiac arrest (OHCA). Methods: We measured plasma concentrations of GFAp and tau of patients included in the previously published COMACARE trial (NCT02698917) on intensive care unit admission and at 24, 48, and 72 h after OHCA, and compared them to ne

Quantifying the impacts of urban morphology on modifying microclimate conditions in extreme weather conditions

It is well-known that the morphology of urban areas modifies the variations of climate variables at microscale; known as microclimate conditions. The complexity of urban morphology can lead to undesired wind conditions or excessive air temperature; particularly in extreme weather conditions. This study attempts to quantify the impacts of urban morphology on the evolution of wind speed and air temp