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This report provides a summary of the third meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative held in San Diego, CA, U.S.A., 6-7 April 2013 (HOME III). The meeting addressed the four domains that had previously been agreed should be measured in every eczema clinical trial: clinical signs, patient-reported symptoms, long-term control and quality of life. Formal presentations
Genetic risk scores (GRS), summing up the total effect of several single-nucleotide polymorphisms (SNPs) in genes associated with either coronary risk or cardiovascular risk factors, have been tested for association with ischemic stroke with conflicting results. Recently an association was found between a GRS based on 29 SNPs discovered by genome-wide association studies and hypertension. The aim
Scintigraphy is the gold standard for objective measurement of delayed gastric tube emptying after esophagectomy. The aim of this pilot study is to validate, by reference to scintigraphy, the paracetamol absorption test for measuring gastric tube emptying in esophagectomized patients.
A generic search for anomalous production of events with at least three charged leptons is presented. The search uses a pp-collision data sample at a center-of-mass energy of root s = 7 TeV corresponding to 4.6 fb(-1) of integrated luminosity collected in 2011 by the ATLAS detector at the CERN Large Hadron Collider. Events are required to contain at least two electrons or muons, while the third le
This paper explores different orientations to child-centered social work as conveyed in the training materials and guidelines of Looking After Children and Assessment Framework in Australia. Canada and Sweden. 'Child centered' is shaped by contextual factors and influences social work practices. We found differences in these approaches as needs based and/or rights based and in relation to how each
A search for contact interactions has been performed using dimuon events recorded with the ATLAS detector in proton-proton collisions at root s = 7 TeV. The data sample corresponds to an integrated luminosity of 42 pb(-1). No significant deviation from the standard model is observed in the dimuon mass spectrum, allowing the following 95% C. L. limits to be set on the energy scale of contact intera
A measurement of the B-s(0) -> J/psi phi decay parameters, updated to include flavor tagging is reported using 4.9 fb(-1) of integrated luminosity collected by the ATLAS detector from root s = 7 TeV pp collisions recorded in 2011 at the LHC. The values measured for the physical parameters are phi(s) = 0.12 +/- 0.25(stat) +/- 0.05(syst) rad Delta Gamma(s) = 0.053 +/- 0.021(stat) +/- 0.010(syst) ps(
The aim of our retrospective study was to determine the extent to which diffusion- and perfusion- weighted MRI combined with conventional MRI could be helpful in the evaluation of intensive care unit (ICU) patients who have unknown or unclear cerebral pathology underlying a serious clinical condition. Twenty-one ICU patients with disparity between the findings on brain CT scan and their clinical s
Plants of Pinus sylvestris L. were grown in mycorrhizal association with Suillus bovinus (Fr.) O. Kuntze in observation chambers until an interconnecting mycelial network had developed between the seedlings. The shoot of an individual seedling was then sealed in a perspex cuvette and exposed to 14CO2. After incubation for 48 h, the 'donor' shoot was removed and components of the mycelial network a
OBJECTIVES: To compare different forms and ratios of serum prostate-specific antigen (PSA) to determine which form or ratio provides optimal diagnostic specificity and sensitivity in distinguishing between benign prostatic hyperplasia (BPH) and clinically localized prostate cancer. METHODS: Serum samples were obtained from 47 patients with BPH and 39 with clinically localized prostate cancer. Pati
Parkinson’s disease is predominantly a dopamine deficiency syndrome, which is produced in the brain by the loss of cells located in a small area in the ventral midbrain called the substantia nigra. Complete unilateral dopamine lesions, based on the administration of toxic substances (ie, 6-hydroxy-dopamine in rats and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice and primates) have been ext
The Swedish Knee Arthroplasty Registry (SKAR) has recorded knee arthroplasties prospectively in Sweden since 1975. The only outcome measure available to date has been revision status. While questionnaires on health outcome may function as more comprehensive endpoints, it is unclear which are the most appropriate. We tested various outcome questionnaires in order to determine which is the best for
BACKGROUND: The objective of this study was to investigate the relationship between history of induced abortion and preterm delivery in various parts of Europe, and according to the main cause of preterm birth. METHODS: We used data from a case–control survey, the EUROPOP study; 2938 preterm births and 4781 controls at term from ten European countries were included. Based on national statistics, w
Patients with an implantable cardioverter defibrillator (ICD) have an ongoing risk of sudden incapacitation that might cause harm to others while driving a car. Driving restrictions vary across different countries in Europe. The most recent recommendations for driving of ICD patients in Europe were published in 1997 and focused mainly on patients implanted for secondary prevention. In recent years
The 70Ni nucleus has been produced at the LISOL facility and its beta decay to 70Cu has been observed. In parallel, the 70Cu nucleus has been produced at the ISOLDE facility. A new third beta-decaying isomeric state in 70Cu has been identified, partly with the aid of the in-source laser spectroscopy method. Its measured half-life is T1/2=33(2) s. In addition, two isomeric transitions in 70Cu have
A statistical distribution for the number of CDMA RAKE fingers, N T, to be assigned in order to track a given percent of the total received power has been derived. The obtained distribution reveals a strong dependence of NT on the system bandwidth, the median RMS delay spread, its standard deviation and other environment specific parameters. Also, a statistical distribution for the fading width fw
A virtual reality (VR) experiment with 96 participants was carried out in a Cave Automatic Virtual Environment (CAVE) laboratory at Lund University to provide recommendations on the design of flashing lights at emergency exit portals for road tunnel emergency evacuation. A set of variables were investigated, namely 1) Colour of flashing lights, 2) Flashing rate, 3) The type of light source, 4) The
BACKGROUND The sperm chromatin structure assay (SCSA) parameter DNA fragmentation index (DFI) has been shown to predict in vivo and in vitro fertility. So far most SCSA studies have been based on SCSA analysis performed on neat semen. The aim of this study is to assess whether SCSA analysis of sperm prepared by density gradient centrifugation (DGC) could add more information in regard to the predi
Purpose Earlier studies have shown that endogenous gonadal hormones play an important role in the etiology of breast cancer among BRCA1/ 2 mutation carriers. So far, little is known about the safety of exogenous hormonal use in mutation carriers. In this study, we examined the association between oral contraceptive use and risk of breast cancer among BRCA1/ 2 carriers. Patients and Methods In the
